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848 条记录 (耗时 0.023 秒)

    Device mounting apparatus
    4.
    外观设计
    Device mounting apparatus 有权

    公开(公告)号：USD1042614S1

    公开(公告)日：2024-09-17

    申请号：US29773917

    申请日：2021-03-12

    申请人： Engineered Network Systems, LLC

    设计人： Terry Strand

    摘要： FIG. 1 is an upper perspective view of a device mounting apparatus;
    FIG. 2 is a lower perspective view of the device mounting apparatus;
    FIG. 3 is a front elevational view of the device mounting apparatus;
    FIG. 4 is a right side elevational view of the device mounting apparatus;
    FIG. 5 is a bottom plan view of the device mounting apparatus;
    FIG. 6 is a left side elevational view of the device mounting apparatus; and,
    FIG. 7 is a top plan view of the device mounting apparatus.
    The broken line showing of environmental structure is for illustrative purposes only, and forms no part of the claimed design.

    Preparation and use of sugar-targeting nanoparticles for modifying SiRNA
    6.
    发明授权
    Preparation and use of sugar-targeting nanoparticles for modifying SiRNA 有权

    公开(公告)号：US12053550B2

    公开(公告)日：2024-08-06

    申请号：US17110525

    申请日：2020-12-03

    申请人： HENAN UNIVERSITY

    发明人： Bingyang Shi ,  Feiyan Zhu ,  Meng Zheng ,  Yang Liu

    IPC分类号： A61K9/51 ,  C12N15/113

    CPC分类号： A61K9/5123 ,  A61K9/5146 ,  A61K9/5192 ,  C12N15/1137 ,  C12N2310/14

    摘要： The present disclosure discloses preparation and use of sugar-targeting nanoparticles for modifying siRNA. A sugar-targeting nanoparticle, including targeting nanocarriers, wherein the targeting nanocarriers are formed by linking in sequence a targeting molecule, a first linking compound, a first hydrophilic biomaterial, a second linking compound and a cationic compound through chemical bonds; the first linking compound and the second linking compound both have a carboxyl group; the first linking compound has a maleimido group at the same time, and the targeting molecule is a cycloaldohexose. Providing the cycloaldohexose as the targeting molecule facilitates the nanoparticles targeting the GLUT-1 protein on the capillary endothelial cell membrane on the blood brain barrier, and the nanoparticles are transferred to the brain with high efficiency through the effect of the GLUT-1 protein to transport cycloaldohexose, thereby effectively penetrating the blood brain barrier, and helping to improve the efficiency of sugar-targeting nanoparticles penetrating the BBB.

    Magnetic field distortion detection and correction in a magnetic localization system
    7.
    发明授权
    Magnetic field distortion detection and correction in a magnetic localization system 有权

    公开(公告)号：US12042263B2

    公开(公告)日：2024-07-23

    申请号：US17604297

    申请日：2020-04-16

    申请人： St. Jude Medical, Cardiology Division, Inc.

    发明人： Alexander P. Thome

    IPC分类号： A61B5/06 ,  A61B5/00 ,  G01R33/28 ,  G01R33/56

    CPC分类号： A61B5/062 ,  A61B5/6852 ,  G01R33/285 ,  G01R33/56

    摘要： Aspects of the present disclosure are directed to systems and apparatuses for detecting and correcting for magnetic field distortions within a magnetic field used for medical magnetic localization systems. In one example embodiment, a system is disclosed including a magnetic field generator and a magnetic detection sensor. The magnetic field generator generates the magnetic field for localization of a catheter within the patient. The magnetic detection sensor includes a plurality of sensor coils positioned at fixed distances and orientations relative to one another. Each of the sensor coils sense the magnetic field within a sensing region aligned with a longitudinal axis of the sensor coil, and outputs an electrical signal indicative of the sensed magnetic field. The plurality of sensing coils form two substantially contiguous sensing regions, a first continuous sensing region above the magnetic detection sensor, and a second continuous sensing region below the magnetic detection sensor.

    Holder for insert and assembly including the holder and insert
    10.
    发明授权
    Holder for insert and assembly including the holder and insert 有权

    公开(公告)号：US12012987B2

    公开(公告)日：2024-06-18

    申请号：US17245492

    申请日：2021-04-30

    申请人： HellermannTyton S.A.S.

    发明人： Damien Nampon ,  Pascal Cherdo

    IPC分类号： F16B43/00 ,  F16B41/00

    CPC分类号： F16B41/002 ,  F16B2200/20

    摘要： A holder for an insert includes a first housing configured to receive the insert. The first housing extends within a plane of the holder. The holder further includes an opening configured for inserting the insert into the first housing in a direction substantially perpendicularly to the plane and a second housing configured to receive the insert, the second housing being in communication with the first housing. The second housing extends within the plane of the holder and is configured to prevent movement of the insert out of the holder in a direction perpendicular to the plane.