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公开(公告)号:US11617357B2
公开(公告)日:2023-04-04
申请号:US16729798
申请日:2019-12-30
IPC分类号: A01K67/027 , C07K16/46 , C12N9/64 , C07K16/28
摘要: Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
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公开(公告)号:US11615429B2
公开(公告)日:2023-03-28
申请号:US17149389
申请日:2021-01-14
申请人: Venminder, Inc.
发明人: Dana A. Bowers
IPC分类号: G06Q30/00 , G06Q30/018 , G06F40/186
摘要: Methods and systems are presented herein for assessing risk associated with a vendor providing services and/or other products to a financial institution, for preparation of associated risk assessment reports or vendor oversight reports, and for maintenance of a plurality of risk assessment reports or oversight reports associated with a plurality of vendors.
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公开(公告)号:US11584955B2
公开(公告)日:2023-02-21
申请号:US17224541
申请日:2021-04-07
发明人: Jin Wang , Qiuxiang Cheng , Shiyuan Li , Xiaoyan Li , Linxian Li
IPC分类号: C12Q1/6823
摘要: The present invention provides a use of a Cas protein, and a method and a kit for detecting target nucleic acid molecules. The method for detecting target nucleic acid molecules comprises adding a guide RNA, a Cas12a, and a nucleic acid probe into a reaction system containing target nucleic acid molecules to be detected, and detecting it after the reaction is completed.
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公开(公告)号:US11584757B2
公开(公告)日:2023-02-21
申请号:US16802654
申请日:2020-02-27
申请人: Celgene CAR LLC
发明人: Matthew David Alexander , Claudio Chuaqui , John Malona , Joseph John McDonald , Yike Ni , Deqiang Niu , Russell C. Petter , Juswinder Singh , Chittari Pabba
IPC分类号: A61K31/551 , A61P25/00 , A61P31/00 , C07D495/14 , A61P37/00 , A61P35/00
摘要: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号:US11579785B2
公开(公告)日:2023-02-14
申请号:US17062144
申请日:2020-10-02
申请人: Quobyte Inc.
发明人: Felix Hupfeld , Felix Langner , Robert Döbbelin
摘要: Technologies are provided to ensure integrity of erasure coded data that is subject to read and write access from distributed processes. Multiple processes that access erasure coded data can be coordinated in an efficient, scalable and fault-tolerant manner so that integrity of the original data is maintained. The Technologies include a fault-tolerant access coordination protocol that ensures exclusive write access by a client. The coordination protocol achieves scalability by not relying on centralized components, and achieves efficiency and performance by piggy-packing access coordination messages on operations of the underlying erasure coding protocol.
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公开(公告)号:US11538849B2
公开(公告)日:2022-12-27
申请号:US16886625
申请日:2020-05-28
IPC分类号: H01L27/15 , H01L33/62 , H01L25/065 , H01L33/36
摘要: A multi-LED structure comprises a first LED and a separate second LED disposed on a common multi-LED native substrate. The LEDs each comprise a common first layer having a cantilever portion and a base portion and a common second layer having a light-emitting emission portion disposed only over the base portion. An LED electrode electrically connects the first LED to the second LED. The cantilever portion extends in a direction different from the base portion or a length of the cantilever portion is less than a distance between the emission portions of the first and second LEDs.
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公开(公告)号:US11535706B2
公开(公告)日:2022-12-27
申请号:US17095827
申请日:2020-11-12
发明人: Scott D. Allen , Geoffrey W. Coates , Anna E. Cherian , Chris A. Simoneau , Alexei A. Gridnev , Jay J. Farmer
摘要: In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having two or more sites that can initiate polymerization. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups and a high percentage of carbonate linkages. The compositions are further characterized in that they contain polymer chains having an embedded polyfunctional moiety linked to a plurality of individual polycarbonate chains.
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公开(公告)号:US11527691B2
公开(公告)日:2022-12-13
申请号:US17372314
申请日:2021-07-09
发明人: Christopher Andrew Bower , Matthew Alexander Meitl , Ronald S. Cok , Salvatore Bonafede , Brook Raymond , Andrew Tyler Pearson
IPC分类号: H01L33/62 , H01L23/48 , H01L23/498 , H01L23/52
摘要: A printed structure includes a destination substrate comprising two or more contact pads disposed on or in a surface of the destination substrate, a component disposed on the surface, and two or more electrically conductive connection posts. Each of the connection posts extends from a common side of the component. Each of the connection posts is in electrical and physical contact with one of the contact pads. The component is tilted with respect to the surface of the destination substrate. Each of the connection posts has a flat distal surface.
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公开(公告)号:US11495172B2
公开(公告)日:2022-11-08
申请号:US17074596
申请日:2020-10-19
IPC分类号: G09G3/32 , H01L25/16 , G09G3/3208
摘要: A flat-panel display comprises a display substrate, an array of pixels distributed in rows and columns over the display substrate, the array having a column-control side, and column controller disposed on the column-control side of the array providing column data to the array of pixels through column-data lines. In some embodiments, rows of pixels in the array of pixels form row groups and each column of pixels in a row group receives column data through a separate column-data line. In some embodiments, each pixel in each column of pixels in the array of pixels is serially connected and each pixel in the array of pixels comprises a token-passing circuit for passing a token through the serially connected column of pixels.
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公开(公告)号:US11488943B2
公开(公告)日:2022-11-01
申请号:US17030347
申请日:2020-09-23
发明人: Christopher Andrew Bower , Matthew Alexander Meitl , Ronald S. Cok , Salvatore Bonafede , Brook Raymond , Andrew Tyler Pearson , Erik Paul Vick
摘要: An example of a pixel module comprises a module substrate having light emitters disposed on a light-emitter surface and a controller disposed on a controller surface opposed to the light-emitter surface. At least one module electrode is electrically connected to the controller and at least one module electrode is electrically connected to each light emitter. An example of a pixel-module wafer comprises a module source wafer comprising sacrificial portions and module anchors, each sacrificial portion laterally separated from an adjacent sacrificial portion by a module anchor and a pixel module disposed entirely over each sacrificial portion. At least one module tether physically connects each of the pixel modules to at least one of the module anchors. An example of a pixel-module display comprises a display substrate, pixel modules disposed on the display substrate and display electrodes disposed on the display substrate, each display electrode electrically connected to a module electrode.
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