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    Apparatus and method for treating a substrate with solid particles
    8.
    发明授权
    Apparatus and method for treating a substrate with solid particles 有权

    公开(公告)号：US12091801B2

    公开(公告)日：2024-09-17

    申请号：US17258406

    申请日：2019-07-12

    申请人： Xeros Limited

    发明人： Gareth Evan Lyn Jones ,  Christopher Holden ,  David Stevens

    IPC分类号： D06F35/00 ,  D06F21/02 ,  D06F37/06 ,  D06M23/08

    CPC分类号： D06F35/006 ,  D06F21/02 ,  D06F37/06 ,  D06M23/08

    摘要： An apparatus, method and kit for use in the treatment of substrates with a solid particulate material, said apparatus comprising a housing having mounted therein a rotatably mounted drum having an inner surface and an end wall and access means for introducing said substrates into said drum, the drum preferably having and elongate protrusion (1) located on said inner surface of said drum, wherein •(a) said drum comprises storage means for storage of said solid particulate material; and •(b) said drum comprises a first collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a first collecting direction, characterised in that said drum comprises a second collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a second collecting direction, wherein said second collecting direction is in the opposite rotational direction to said first collecting direction, and wherein said first collecting flow path and said second collecting flow path are different flow paths.

    Medicament for use in a method of inducing or extending a cellular cytotoxic immune response
    9.
    发明授权
    Medicament for use in a method of inducing or extending a cellular cytotoxic immune response 有权

    公开(公告)号：US12090194B2

    公开(公告)日：2024-09-17

    申请号：US16953891

    申请日：2020-11-20

    申请人： Bundesrepublik Deutschland letztvertreten durch das Robert Koch-Institut vertreten durch seinen Präsidenten

    发明人： Richard Kroczek

    IPC分类号： C12N5/00 ,  A61K39/00 ,  C12N5/02

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/545 ,  A61K2039/55533 ,  A61K2039/55561 ,  A61K2039/572

    摘要： The present invention relates to a medicament for use in a method of inducing a cellular cytotoxic immune response, the method comprising the steps of: i) administering to a patient a delivery system comprising (a) a molecule binding to a receptor on the surface of a dendritic cell, (b) an antigen-comprising protein bound to molecule of (a) and (c) a first adjuvant, wherein upon binding of the molecule of (a) to the receptor, the protein of (b) is internalized and processed in the dendritic cell and the antigen comprised in the protein is presented on the surface of the dendritic cell, thereby activating a T cell in the patient; and ii) administering to the patient a re-activator selected from the group consisting of (d) complexed interleukin 2 (IL-2cx), (e) a peptide-loaded major histocompatibility complex class I (MHC-I) presenting cell and a second adjuvant, and (f) a combination of (d) and (e), wherein the peptide is derived from the antigen-comprising protein as defined in step i), thereby reactivating the T cell activated in step i), wherein the re-activator of step ii) is administered in a time frame of from 0 h to 14 days after the administration of the delivery system of step i).