公开(公告)号：US09225194B2

公开(公告)日：2015-12-29

申请号：US13869484

申请日：2013-04-24

申请人： CYBERONICS, INC.

发明人： Himanshu Joshi

IPC分类号： H02J7/00 ,  A61N1/00 ,  H02J7/02 ,  H01F38/14 ,  A61N1/378 ,  A61N1/372

CPC分类号： H02J50/80 ,  A61N1/37223 ,  A61N1/3787 ,  H01F38/14 ,  H02J50/12

摘要： An implantable medical device charging apparatus includes a charging circuit. The charging circuit includes a series resonator responsive to a signal applied to the charging circuit. During operation, the series resonator inductively couples to a secondary coil within an implantable medical device to transfer energy to the secondary coil. The charging circuit also includes a parallel resonator coupled to the series resonator. The parallel resonator filters a first component of the signal from propagating to the series resonator.

摘要翻译： 一种植入式医疗装置充电装置包括充电电路。 充电电路包括响应于施加到充电电路的信号的串联谐振器。 在操作期间，串联谐振器电感耦合到可植入医疗装置内的次级线圈以将能量传递到次级线圈。 充电电路还包括耦合到串联谐振器的并联谐振器。 并联谐振器对信号的第一分量进行滤波，从而传播到串联谐振器。

公开(公告)号：US09220910B2

公开(公告)日：2015-12-29

申请号：US14149409

申请日：2014-01-07

申请人： CYBERONICS, INC.

发明人： John C. Colborn

IPC分类号： A61B5/00 ,  A61N1/372 ,  A61B5/0245 ,  A61B5/11 ,  A61N1/36 ,  G06F19/00 ,  A61B5/053 ,  A61B5/0215

CPC分类号： A61N1/37252 ,  A61B5/002 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/053 ,  A61B5/1112 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/6833 ,  A61B5/6847 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61N1/36064 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G16H50/20

摘要： A seizure detection device includes a coordinate data interface configured to receive coordinate data for a human, a memory to store coordinate data for a defined location of the human, and a seizure detector configured to identify a seizure event responsive to the coordinate data.

摘要翻译： 缉获检测装置包括被配置为接收人的坐标数据的坐标数据接口，存储器，用于存储针对人的定义位置的坐标数据;以及检测检测器，被配置为根据坐标数据识别发作事件。

公开(公告)号：US08694118B2

公开(公告)日：2014-04-08

申请号：US11262465

申请日：2005-10-28

申请人： Randolph K. Armstrong

发明人： Randolph K. Armstrong

IPC分类号： A61N1/00

CPC分类号： A61N1/36139 ,  A61N1/36114

摘要： A method, system, and apparatus for providing a stimulation signal comprising a variable ramping portion using an implantable medical device (IMD). The first electrical comprises a first ramping portion. The first ramping portion comprises a first parameter selected from the group consisting of an amplitude, a rate of change of the amplitude, a time period of a rate of change of the amplitude, a pulse width, a rate of change of the pulse width, a time period of a rate of change of the pulse width, a frequency, a rate of change of the frequency, a time period of a rate of change of the frequency, and a duration of a time period of the ramping portion, the first parameter having a first value. The first electrical signal is applied to a target location of the patient's body. A second electrical signal comprising a second ramping portion is generated. The second ramping portion comprises the first parameter having a second value that is different from the first value. The second electrical signal is applied to a target location of the patient's body.

摘要翻译： 一种用于使用可植入医疗装置（IMD）提供包括可变斜坡部分的刺激信号的方法，系统和装置。 第一电气包括第一斜坡部分。 第一斜坡部分包括从振幅，振幅变化率，振幅变化率的时间周期，脉冲宽度，脉冲宽度变化率， 脉冲宽度的变化率，频率，频率变化率，频率变化率的时间段以及斜坡部分的时间段的持续时间的时间段，第一 参数具有第一个值。 第一电信号被施加到患者身体的目标位置。 产生包括第二斜坡部分的第二电信号。 第二斜坡部分包括具有不同于第一值的第二值的第一参数。 第二电信号被施加到患者身体的目标位置。

公开(公告)号：US08639354B2

公开(公告)日：2014-01-28

申请号：US13252028

申请日：2011-10-03

申请人： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Scott T. Mazar

发明人： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Scott T. Mazar

IPC分类号： A61N1/05

CPC分类号： A61N1/3606 ,  A61B5/0809 ,  A61B5/4818 ,  A61B5/7239 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/3601 ,  A61N1/37229

摘要： In an embodiment, a lead system includes a cuff electrode to secure to a nerve, a first lead portion defining a longitudinal axis, and a second lead portion. An anchor may be between the first lead portion and the second lead portion to secure to non-nerve structure. A connector may extend from the second lead portion to connect to a pulse generator. Electrode elements are spaced apart along the cuff body. The cuff electrode may include a first resilient arcuate-shaped portion extending in a first circumferential direction and having a first arc length; and a second resilient arcuate-shaped portion integrally formed with the first arcuate-shaped portion, extending in a second circumferential direction, and having a second arm length greater that the first arc length. The second arcuate-shaped portion overlaps the first arcuate-shaped portion, The first and second arcuate-shaped portions define a lumen having a substantially re-closable opening.

摘要翻译： 在一个实施例中，引导系统包括固定到神经的袖带电极，限定纵向轴线的第一引线部分和第二引线部分。 锚可以在第一引线部分和第二引线部分之间，以固定到非神经结构。 连接器可以从第二引线部分延伸以连接到脉冲发生器。 电极元件沿袖带体间隔开。 袖带电极可以包括在第一圆周方向上延伸并且具有第一弧长的第一弹性弧形部分; 以及与第一弧形部分整体形成的第二弹性弓形部分，其在第二圆周方向上延伸，并且具有比第一弧长更大的第二弧长。 第二弧形部分与第一弧形部分重叠。第一和第二弧形部分限定具有基本可再闭合的开口的内腔。

公开(公告)号：US08626304B2

公开(公告)日：2014-01-07

申请号：US12980743

申请日：2010-12-29

申请人： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Scott T. Mazar

发明人： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Scott T. Mazar

IPC分类号： A61N1/36

CPC分类号： A61N1/3606 ,  A61B5/0809 ,  A61B5/4818 ,  A61B5/7239 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/3601 ,  A61N1/37229

摘要： In one embodiment, a method of treating an upper airway may include delivering a first electrical stimulation to a first portion of a nerve innervating a first upper airway muscle via a plurality of electrodes adjacent the nerve. The method may further include delivering a second electrical stimulation to a second portion of the nerve innervating a second upper airway muscle via the plurality of electrodes, wherein the second muscle is different from the first muscle.

摘要翻译： 在一个实施方案中，治疗上呼吸道的方法可包括通过邻近神经的多个电极将第一电刺激递送至神经支配第一上呼吸道肌肉的神经的第一部分。 该方法还可以包括通过多个电极向神经的第二部分输送第二上呼吸道肌肉，其中第二肌肉与第一肌肉不同。

公开(公告)号：US08577458B1

公开(公告)日：2013-11-05

申请号：US13314126

申请日：2011-12-07

申请人： Imad Libbus ,  Badri Amurthur ,  Bruce H. KenKnight

发明人： Imad Libbus ,  Badri Amurthur ,  Bruce H. KenKnight

IPC分类号： A61N1/05

CPC分类号： A61N1/3702 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36175

摘要： An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and to record the sensed heart rate as data into a memory.

摘要翻译： 提供了一种用于提供用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激用于无引导心率监测的可植入装置。 刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。 神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。 神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射， 方向动作电位。 最后，神经刺激器包括被配置为感测心率并将感测的心率作为数据记录到存储器中的集成的无引线心率传感器。

公开(公告)号：US08565867B2

公开(公告)日：2013-10-22

申请号：US12020097

申请日：2008-01-25

申请人： Randolph K. Armstrong ,  Steven E. Maschino ,  Timothy L. Scott

发明人： Randolph K. Armstrong ,  Steven E. Maschino ,  Timothy L. Scott

IPC分类号： A61N1/372

CPC分类号： A61N1/36185 ,  A61N1/36114 ,  A61N1/36117

摘要： We disclose a method of treating a medical condition in a patient using an implantable medical device including coupling at least a first electrode and a second electrode to a cranial nerve of the patient, providing a programmable electrical signal generator coupled to the first electrode and the second electrode, generating a first electrical signal with the electrical signal generator, applying the first electrical signal to the electrodes, wherein the first electrode is a cathode and the second electrode is an anode, reversing the polarity of the first electrode and the second electrode, yielding a configuration wherein the first electrode is an anode and the second electrode is a cathode, generating a second electrical signal with the electrical signal generator, applying the second electrical signal to the electrodes, reversing the polarity of the first electrode and the second electrode, yielding a configuration wherein the first electrode is a cathode and the second electrode is an anode, generating a third electrical signal with the electrical signal generator, and applying the third electrical signal to the electrodes. Each of the electrical signals can independently contain one or more pulses or one or more bursts. The number of pulses need not be equal between any two of the electrical signals.

公开(公告)号：US08543199B2

公开(公告)日：2013-09-24

申请号：US13225241

申请日：2011-09-02

申请人： David Snyder ,  Kent W. Leyde ,  John F. Harris

发明人： David Snyder ,  Kent W. Leyde ,  John F. Harris

IPC分类号： A61B5/04

CPC分类号： A61B5/02055 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0452 ,  A61B5/048 ,  A61B5/08 ,  A61B5/145 ,  A61B5/14552 ,  A61B5/4094 ,  A61B5/7232 ,  A61B2560/0219

摘要： Systems and methods of monitoring a subject's neurological condition are provided. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition. The systems and methods may utilize a minimally invasive, leadless device to monitor the subject's condition. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition.

摘要翻译： 提供了监测受试者神经系统状况的系统和方法。 在一些实施例中，该方法包括分析来自受试者的生理信号（例如EEG）以确定受试者是否处于对立状态的步骤; 并且如果受试者处于对立状态，则向对象提供指示（例如，对受试者和/或照顾者）对象处于对立状态。 系统和方法可以利用微创无引导装置来监测受检者的状况。 在一些实施例中，如果受试者处于预备状态，则该方法包括提供受试者处于预防状态的指示（例如红光）的步骤。

公开(公告)号：US08478428B2

公开(公告)日：2013-07-02

申请号：US12766046

申请日：2010-04-23

申请人： Anthony W. Cowley

发明人： Anthony W. Cowley

IPC分类号： A61N1/05

CPC分类号： A61N1/0556

摘要： A helical electrode for nerve stimulation includes an insulative helical substrate, having an inner surface, configured to wrap around a nerve. An electrical conductor is disposed upon the inner surface of the substrate. The conductor defines a helix of about one revolution and produces an electric field in which an injected current in similar axons varies by no more than about 25%. The conductor may include tapered end sections, which may be counter-tapered.

摘要翻译： 用于神经刺激的螺旋电极包括具有内表面的绝缘螺旋基底，构造成围绕神经缠绕。 电导体设置在基板的内表面上。 导体限定了大约一圈的螺旋线，并产生电场，其中类似轴突中的注入电流变化不超过约25％。 导体可以包括锥形端部，其可以是相对锥度的。

公开(公告)号：US08260426B2

公开(公告)日：2012-09-04

申请号：US12020195

申请日：2008-01-25

申请人： Randolph K. Armstrong ,  Steven E. Maschino ,  Timothy L. Scott

发明人： Randolph K. Armstrong ,  Steven E. Maschino ,  Timothy L. Scott

IPC分类号： A61N1/05

CPC分类号： A61N1/36082 ,  A61N1/36114

摘要： We disclose a method, apparatus, and system of treating a medical condition in a patient using an implantable medical device. A first electrode is coupled to a first portion of a cranial nerve of the patient. A second electrode is coupled to a second portion of the cranial nerve of the patient. A first electrical signal is provided to the first and second electrodes. The first electrical signal is provided in a first polarity configuration in which the first electrode functions as an anode and the second electrode functions as a cathode. Upon termination of the first electrical signal, the anode and cathode each comprise a first accumulated energy. A second electrical signal is provided to the first and second electrodes, in which the second electrical signal includes at least a portion of the first accumulated energy.

摘要翻译： 我们公开了使用可植入医疗装置治疗患者的医疗状况的方法，装置和系统。 第一电极耦合到患者的颅神经的第一部分。 第二电极联接到患者的颅神经的第二部分。 第一电信号被提供给第一和第二电极。 第一电信号以第一极性配置提供，其中第一电极用作阳极，第二电极用作阴极。 在第一电信号终止时，阳极和阴极各自包括第一累积能量。 第二电信号被提供给第一和第二电极，其中第二电信号包括第一累积能量的至少一部分。