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    Multi-modal fluid condition sensor platform and system therefor
    1.
    发明授权
    Multi-modal fluid condition sensor platform and system therefor 有权
    多模态流体状况传感器平台及其系统

    公开(公告)号：US09020766B2

    公开(公告)日：2015-04-28

    申请号：US13621599

    申请日：2012-09-17

    申请人： Mastinc

    发明人： Brian Von Herzen ,  Steven Van Fleet

    IPC分类号： G06F17/00 ,  G01M15/05 ,  G06F17/10 ,  F16N29/00 ,  G01N29/02 ,  G01M15/04 ,  F01M11/10

    CPC分类号： G01N33/30 ,  B01D35/143 ,  B01D2201/54 ,  F01M11/10 ,  F16N29/00 ,  F16N2250/00 ,  F16N2270/50 ,  G01M15/042 ,  G01M15/048 ,  G01M15/05 ,  G01M15/09 ,  G01N21/95 ,  G01N27/02 ,  G01N27/74 ,  G01N29/02 ,  G01N33/2888 ,  G06F17/10 ,  H04Q9/00

    摘要： This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission. Described herein is a real-time, simultaneous, integrated, multi-modal sensor system for early warning notification that can be further enhanced using specifically designed nanoparticles that can be introduced into the system, engineered to specifically bind with the contaminants and/or undergo an irreversible state change upon certain experienced conditions to both increase the detectability as well as provide for a framework to improve filter performance.

    摘要翻译： 本发明包括用于多模式集成同时测量包含在诸如汽车往复式发动机和车辆变速器的循环系统中的流体的各个方面的实施例。 这些循环系统执行恒定的内部润滑，以及热和污染物去除，以保护内部运动部件免受正常操作中的固有摩擦和损坏。 最常见的是，这是通过基于烃和/或相关合成材料的流体实现的，随着时间的推移，它们可能失去其保护性能，并且由于内部和外部事件而导致其性能或击穿/衰减变化。 可以测量润滑剂流体中的几个组件，并且可以深入了解系统执行其设计任务的功效。 这里描述的是用于预警通知的实时，同步，集成的多模式传感器系统，其可以使用可以被引入到系统中的专门设计的纳米颗粒进一步增强，其被设计成与污染物特异性结合和/或经历 不可逆转的状态在某些有经验的条件下改变，以增加可检测性，并提供框架来提高过滤器性能。

    Detection of multiple nucleic acid sequences in a reaction cartridge
    2.
    发明授权
    Detection of multiple nucleic acid sequences in a reaction cartridge 有权
    检测反应筒中的多个核酸序列

    公开(公告)号：US08852863B2

    公开(公告)日：2014-10-07

    申请号：US13318424

    申请日：2010-05-04

    申请人： Thomas Rothmann ,  Holger Engel ,  Ralf Himmelreich ,  Andy Wende ,  Rainer Dahlke

    发明人： Thomas Rothmann ,  Holger Engel ,  Ralf Himmelreich ,  Andy Wende ,  Rainer Dahlke

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6818 ,  Y02A50/59 ,  C12Q2527/107 ,  C12Q2537/143 ,  C12Q2565/629

    摘要： The present invention relates to a method for amplifying and detecting nucleic acid sequences in a reaction cartridge comprising, (i) providing a sample comprising at least one nucleic acid molecule, (ii) in a first reaction chamber of the cartridge providing reagents for an amplification reaction, (iii) mixing the sample with the amplification reagents, (iv) amplifying the at least one nucleic acid in the first reaction chamber of the cartridge, (v) transferring at least parts of the amplification reaction into a second and third reaction chamber of the cartridge each comprising a probe set and performing a melting point analysis in order to determine which of the probes has specifically bound a nucleic acid.

    摘要翻译： 本发明涉及用于扩增和检测反应盒中的核酸序列的方法，其包括：（i）提供包含至少一个核酸分子的样品，（ii）在所述盒的第一反应室中提供用于扩增的试剂 反应，（iii）将样品与扩增试剂混合，（iv）扩增筒的第一反应室中的至少一种核酸，（v）将至少部分扩增反应转移到第二和第三反应室 的每个包含探针组并进行熔点分析，以便确定哪个探针具体结合核酸。

    Facemask
    6.
    外观设计
    Facemask 有权
    面具

    公开(公告)号：USD702401S1

    公开(公告)日：2014-04-08

    申请号：US29451513

    申请日：2013-04-03

    申请人： Beardo, Inc.

    设计人： Jeff Phillips

    GLP-1 fusion peptides, their production and use
    8.
    发明授权
    GLP-1 fusion peptides, their production and use 失效
    GLP-1融合肽，其生产和使用

    公开(公告)号：US08431533B2

    公开(公告)日：2013-04-30

    申请号：US11991562

    申请日：2006-09-22

    申请人： Peter Geigle ,  Christine Wallrapp ,  Eric Thoenes

    发明人： Peter Geigle ,  Christine Wallrapp ,  Eric Thoenes

    IPC分类号： A61K38/45 ,  A61K39/395 ,  A61K38/18 ,  G01N33/567

    CPC分类号： C07K14/605

    摘要： The present invention provides fusion peptides having GLP-1 activity and enhanced stability in vivo, in particular resistancy to dipeptidyl peptidase IV. The fusion peptide comprises as component (I) N-terminally a GLP-1 (7-35, 7-36 or 7-37) sequence and as component (II)C-terminally a peptide sequence of at least 9 amino acids or a functional fragment, variant or derivative thereof. Component (II) is preferably a full or partial version of IP2 (intervening peptide 2). A preferred embodiment comprises the sequence GLP-1 (7-35, 36 or 37)/IP2/GLP-1(7-35, 36 or 37) or GLP-2. The fusion peptide may be produced in engineered cells or synthetically and may be used for the preparation of a medicament for treating various diseases or disorders, e.g. diabetes type 1 or 2, apoptosis related diseases or neurodegenerative disorders.

    摘要翻译： 本发明提供具有GLP-1活性和增强体内稳定性的融合肽，特别是对二肽基肽酶IV的抗性。 融合肽包含作为组分（I）N末端的GLP-1（7-35,7-36或7-37）序列，并且作为组分（II），C末端是至少9个氨基酸的肽序列或 功能片段，变体或衍生物。 组分（II）优选为全部或部分版本的IP2（插入肽2）。 优选的实施方案包括序列GLP-1（7-35,36或37）/ IP2 / GLP-1（7-35,36或37）或GLP-2。 融合肽可以在工程细胞中或合成地制备，并且可以用于制备用于治疗各种疾病或病症的药物。 1型或2型糖尿病，凋亡相关疾病或神经退行性疾病。