公开(公告)号：US09382540B2

公开(公告)日：2016-07-05

申请号：US14701999

申请日：2015-05-01

申请人： Isis Pharmaceuticals, Inc.

发明人： Thazha P. Prakash ,  Punit P. Seth ,  Eric E. Swayze ,  Susan M. Freier ,  Mark J. Graham ,  Rosanne M. Crooke

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC分类号： C07H19/20 ,  C07H15/04 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2310/3525 ,  C12N2310/3231

摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease and/or metabolic disease, or a symptom thereof, in an individual in need thereof.

摘要翻译： 本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于还原动物体内脂质和/或葡萄糖的方法，化合物和组合物。 这样的方法，化合物和组合物可用于治疗，预防，延迟或改善有需要的个体的任何一种或多种心血管疾病和/或代谢疾病或其症状。

公开(公告)号：US09725479B2

公开(公告)日：2017-08-08

申请号：US13696796

申请日：2011-04-22

申请人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Ivan Zlatev ,  Eric E. Swayze ,  Thazha P. Prakash ,  Walter F. Lima

发明人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Ivan Zlatev ,  Eric E. Swayze ,  Thazha P. Prakash ,  Walter F. Lima

IPC分类号： C07H17/02 ,  C07H19/067 ,  C07H21/02 ,  C12N15/113

CPC分类号： C07H17/02 ,  C07H19/067 ,  C07H21/02 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3521 ,  C12N2310/3525

摘要： The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.