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公开(公告)号：US11975445B2
公开(公告)日：2024-05-07
申请号：US17396189
申请日：2021-08-06
CPC分类号： B25J19/0075 , A61B34/30 , A61B34/70 , A61B46/10 , B25J15/0408 , A61B2017/00477 , A61B2034/305
摘要： An end effector is removably connected to a robot arm under sterile conditions with an arm mount module configured to be connected to the robot arm, and an arm drape module configured to be removably connected to the arm mount module by a first locking mechanism. A third module may be configured to be removably connected to the arm drape module by a second locking mechanism. A sterile hand drape module may be configured to be removably connected to the arm drape module by the second locking mechanism; and a hand mount module may be configured to be removably connected to the hand drape module by a third locking mechanism, and to be connected to the end effector or the hand mount module is the end effector itself. A transmission pathway for signals, electrical energy, or mechanical energy is provided between the robot arm and the end effector.
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公开(公告)号：US11911048B2
公开(公告)日：2024-02-27
申请号：US17541676
申请日：2021-12-03
发明人： Michael McGurk , Henri Défossez , Simon Wampfler , Gregor Spreiter , Frederic Gueissaz , Marcel Schweizer , Said Ghammar , Andreas Baeriswyl , Mirko Rocci , Steffan Daniel
CPC分类号： A61B17/1728 , A61B2017/0046 , A61B2017/00862 , A61B2090/034
摘要： A drill guide handle configured to engage a variable angle drill guide, including: a handle grip; a first cannula extending from a proximal end of the drill guide handle to a distal end of the drill guide handle, wherein the first cannula is configured to provide a zero degree insertion angle for a drill bit; and a body including: a first tab and a second tab wherein the first and second tabs include a first and second tab protrusion, respectively, wherein each of the first tab and the second is configured to flex so that the first and second tab protrusions engage a horizontal groove on a variable angle drill guide; and a body protrusion on an inner surface of the body, wherein the body protrusion is configured to engage a vertical grove on the variable angle drill guide.
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公开(公告)号：US11781155B2
公开(公告)日：2023-10-10
申请号：US17204312
申请日：2021-03-17
申请人： Kerstin Wunderlich , Jort Vellinga
发明人： Kerstin Wunderlich , Jort Vellinga
CPC分类号： C12N15/86 , C12N15/85 , A61K2039/53 , A61K2039/70 , C12N2710/10321 , C12N2710/10343 , C12N2710/16122 , C12N2710/16143 , C12N2830/15 , C12N2830/205
摘要： The invention provides a bidirectional hCMV-rhCMV promoter and recombinant vectors and recombinant virus comprising the bidirectional hCMV-rhCMV promoter operably linked to a first transgene in one direction and to a second transgene in the opposite direction. The invention also provides methods of making and using such recombinant vectors and recombinant virus.
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公开(公告)号：US11723723B2
公开(公告)日：2023-08-15
申请号：US17384319
申请日：2021-07-23
发明人： Steffan Daniel , Andre Furrer , Simon Bosshard
CPC分类号： A61B34/10 , A61B17/56 , A61B17/64 , A61B17/66 , A61B17/72 , A61B2017/0092 , A61B2017/00862 , A61B2017/00964 , A61B2017/564 , A61B2017/681 , A61B2034/104 , A61B2034/105
摘要： A bone fracture fixation system including reference pins inserted into bone fragments of a patient in a first configuration and an image capture device configured to capture an image of the reference pins, and the bone fragments. The system includes a processor configured to receive and pre-process the captured image data. The processor pre-processes the image data by virtually re-positioning the reference pins in the first configuration into a second configuration, wherein the re-positioning virtually re-positions the bone fragments into normal alignment; and virtually generating a support device. The system includes a point-of-care production apparatus that produces a three-dimensional model of the virtually generated support device in a form that can be applied to the patient. The three-dimensional support device generated by the point-of-care production apparatus is configured to receive the reference pins in the first configuration; and simultaneously re-positions and fixes the bone fragments into normal alignment.
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公开(公告)号：US11701132B2
公开(公告)日：2023-07-18
申请号：US17212600
申请日：2021-03-25
CPC分类号： A61B17/1721 , A61B17/1604 , A61B17/1615 , A61B17/1633 , A61B17/1668 , A61B17/1697 , A61B17/1725 , A61B17/1753 , A61B17/3472 , A61B2017/564
摘要： A system for penetrating the lateral cortex of a long bone includes a tubular cortex penetrator having an inner surface and an outer surface, a proximal end, and a distal end comprising a beveled cutting edge configured to penetrate the lateral cortex. A guide wire is configured to pass over the tubular cortex penetrator, and a guide sleeve is configured to surround the outer surface of the tubular cortex penetrator. A hollow extraction screw with an axial bore, a proximal end, a distal end, and a threaded cutting edge is configured to pass through the axial bore of the hollow extraction screw; and the hollow extraction screw is configured to retract into a distal end of a bore through the tubular cortex penetrator.
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公开(公告)号：US11565251B2
公开(公告)日：2023-01-31
申请号：US16786335
申请日：2020-02-10
发明人： Paul Lockman
摘要： A microfluidic device is useful for modelling drug transmission across the vasculature and vascular barriers. The device includes a frame, a fluid-permeable lumen configured to carry a fluid through the frame in a first direction, a first chamber surrounding the lumen, and a second chamber surrounding the first fluid-permeable chamber. At least one surface of the first chamber is configured for deposition of a first population of endothelial cells. An outer surface of the second chamber is configured for deposition a second population of cells. The second chamber is configured to carry a fluid through the frame in a second direction. The fluid-permeable lumen is configured to allow the fluid to permeate through a wall of the lumen into the first chamber, and the first chamber and the second chamber are in fluid communication with each other.
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公开(公告)号：US11564765B2
公开(公告)日：2023-01-31
申请号：US17519991
申请日：2021-11-05
摘要： A medical package containing a medical article, including: a support element comprising a hollow support tube and a support cap, wherein the support element includes a first chamber configured to enclose the medical article and wherein the support cap includes a support structure configured to hold the medical article captive; a stopper configured to be coupled to the hollow support tube in such a way that the support element has a grip part that protrudes from the stopper, the grip part of the support element configured to be held by a hand of a person; a hollow protective cover configured to be coupled to the stopper in such a way as to delimit, in cooperation with the stopper, a second chamber inside which there extends the grip part of the support element, the hollow protective cover configured to be separated from the stopper, wherein when the hollow protective cover is coupled to the stopper, a part of the stopper protrudes from the hollow protective cover, and is configured to form a grip end of the stopper that is configured to be held by a hand of a person, when the hollow protective cover is separated from the stopper, wherein a part of the support element is configured to be engaged by force inside the stopper, and when the hollow protective cover is separated from the stopper, the support element remains coupled to the stopper while the support element is also separable from the stopper when a person holds the grip part of the support element and pulls the support element so as to separate it from the stopper.
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公开(公告)号：US11504344B2
公开(公告)日：2022-11-22
申请号：US16541770
申请日：2019-08-15
申请人： John H. Owoc
发明人： John H. Owoc
IPC分类号： A61K31/352 , A61K31/05 , A61K9/00 , A61K31/522 , A61K31/4375 , A61P25/28 , A61K9/14
摘要： This invention discloses a nutritional composition of matter that effectively provide a nootropic effect beyond the effects simple obtain by cannabinoids alone. Effectively reduce anxiety due to ingestion of xanthines containing oral products. Similarly reduce the side effects associated with the exogenous ingestion of yohimbine and its derivatives.
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公开(公告)号：US11376294B2
公开(公告)日：2022-07-05
申请号：US16365015
申请日：2019-03-26
发明人： Miguel Jimenez del Rio , Julia C. Wiebe , Laura Lopez-Rios , Tanausu Vega-Morales , Ruben Perez-Machin , Alvaro Sanchez-Rodriquez , Carlos J. Mateos , Nigel Peter Gericke
IPC分类号： A61K36/22 , A61K36/48 , A61K36/51 , A61K36/38 , A61K36/725 , A61K31/522 , A61K36/69 , A61K31/352 , A61K31/7048 , A61P25/00 , A61K36/8905 , A61K45/06 , A61K36/37 , A61K9/48 , A61K9/68 , A61K9/00 , A61K9/46
摘要： A method for enhancing at least one of alertness, attention, concentration and memory in a person in need thereof, comprising co-administering an effective amount of mangiferin, norathyriol, or an extract comprising mangiferin or norathyriol; and caffeine to the person. The components may be co-administered in a single composition, or administered in separate compositions. The mangiferin and/or norathyriol exhibit synergistic effects on brain wave activity when co-administered with caffeine.
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公开(公告)号：US11272968B2
公开(公告)日：2022-03-15
申请号：US16150747
申请日：2018-10-03
发明人： David W. Bogle
摘要： A bone plate comprises a body including an elongated opening extending therethrough, the opening being open at a distal end of the body and including a distal portion and a proximal portion, the distal portion having a width smaller than a width of the proximal portion, the width being a dimension between two longitudinal sides of the opening extending parallel to a longitudinal axis of the body, the body further including an insert including a head portion and a base portion, the base portion being shaped to be slidably mounted within the proximal portion of the opening, a diameter of the base portion being larger than a width of the distal portion of the opening such that the base portion is prevented from exiting the opening through the distal portion thereof, the insert further including a central fixation element receiving hole configured to receive a bone fixation element therethrough.
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