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747 条记录 (耗时 0.037 秒)

    Method for inspecting a liquid metal by ultrasounds
    1.
    发明授权
    Method for inspecting a liquid metal by ultrasounds 有权

    公开(公告)号：US10563285B2

    公开(公告)日：2020-02-18

    申请号：US15516623

    申请日：2015-10-06

    申请人： CONSTELLIUM ISSOIRE

    发明人： Jean-Louis Achard ,  Pierre Le Brun

    IPC分类号： G01N33/205 ,  C22B9/02 ,  B06B3/00 ,  C22B21/06 ,  G01N29/032 ,  G01N29/22

    摘要： The method comprises the following steps: a) Providing a sonotrode (1) formed from an essentially inert material with respect to the liquid metal, such as a ceramic, and preferably a silicon nitride or a silicon oxynitride, such as SIALON, or a metal essentially inert to said liquid metal, b) Immersing at least partially the sonotrode (1) in a bath of said metal, c) Applying to the sonotrode (1) power ultrasounds, particularly ultrasounds having a power greater than 10 watts to obtain the wetting of said sonotrode by said metal, d) Applying continuously to the sonotrode (1) measurement ultrasounds, also known as testing ultrasounds, particularly ultrasounds wherein the frequency is between 1 and 25 MHz, e) Applying intermittently to the sonotrode (1) power ultrasounds, particularly ultrasounds having a power greater than 10 watts, to maintain said wetting.

    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers
    2.
    发明授权
    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers 有权

    公开(公告)号：US10537624B2

    公开(公告)日：2020-01-21

    申请号：US15461020

    申请日：2017-03-16

    申请人： IMMATICS BIOTECHNOLOGIES GMBH

    发明人： Dominik Maurer ,  Leonie Alten ,  Sebastian Bunk

    IPC分类号： C07K14/725 ,  A61K39/00 ,  A61K45/06 ,  G01N33/574

    摘要： The present description relates to T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. In particular, the present description relates to TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as IGF2BP3-001 have the amino acid sequence of KIQEILTQV (SEQ ID NO:1). The present description further relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of cancer. The present description furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

    Bacteriophage detection
    3.
    发明授权
    Bacteriophage detection 有权

    公开(公告)号：US10519516B2

    公开(公告)日：2019-12-31

    申请号：US15589039

    申请日：2017-05-08

    申请人： DSM IP ASSETS B.V.

    发明人： Roelof Hendrik Matthijs Kouwen ,  Douwe Van Sinderen ,  Brian McDonnell

    IPC分类号： C12Q1/70 ,  C12N15/00

    摘要： The present invention relates to a kit suitable for detection of Streptococcus thermophilus infecting phages, said kit comprising: (a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and (b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage. Further, the present invention relates to a method for detecting the presence of Streptococcus thermophilus infecting phages in a sample.

    Phospholipase C
    8.
    发明授权
    Phospholipase C 有权

    公开(公告)号：US10457890B2

    公开(公告)日：2019-10-29

    申请号：US15564275

    申请日：2016-04-08

    申请人： DSM IP ASSETS B.V.

    发明人： Arjen Sein ,  Rene Marcel De Jong ,  Evert Tjeerd Van Rij ,  Willem Bijleveld ,  Maarten Hotse Wilbrink

    IPC分类号： C11B3/00 ,  C12N9/16 ,  C12P7/64 ,  C12P7/20

    摘要： The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1. A process for degumming a vegetable oil comprising contacting a vegetable oil comprising phospholipids with a polypeptide having phospholipase C activity of the invention or a composition of the invention, wherein phospholipids are hydrolyzed into diacylglycerol and phosphate ester and/or phosphate, separating the phosphate ester and/or phosphate from the vegetable oil wherein a degummed vegetable oil is obtained.