公开(公告)号：US12123054B2

公开(公告)日：2024-10-22

申请号：US17545226

申请日：2021-12-08

申请人： Singular Genomics Systems, Inc.

发明人： Eli N. Glezer ,  Abrehet Abdu ,  Timothy Looney

IPC分类号： C12Q1/68 ,  C12Q1/6869

CPC分类号： C12Q1/6869 ,  C12Q1/6869 ,  C12Q2535/122

摘要： Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

公开(公告)号：USD1047223S1

公开(公告)日：2024-10-15

申请号：US29913145

申请日：2023-09-27

申请人： Singular Genomics Systems, Inc.

设计人： Bandele Jeffrey-Coker ,  Eli N. Glezer ,  Anson Hsu ,  Cory Spivey

摘要： FIG. 1 is a front, top, and right side perspective view of a reagent cartridge of our design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a top view thereof; and,
FIG. 7 is a bottom view thereof.
The broken lines, the areas within them, and the unshaded areas bounded by broken lines and solid lines depict portions of the reagent cartridge that form no part of the claimed design.

公开(公告)号：US11973391B2

公开(公告)日：2024-04-30

申请号：US17756236

申请日：2020-11-20

申请人： WePower Technologies LLC

发明人： David Deak ,  Michael Joseph Riddell ,  Lawrence Richenstein

IPC分类号： H02K35/02 ,  H02K7/06 ,  H02K7/18

CPC分类号： H02K35/02 ,  H02K7/06 ,  H02K7/1853 ,  H02K7/1892

摘要： In general, devices and systems for a tangentially actuated magnetic momentum transfer generator, and methods of use thereof, are provided. In an aspect, an electrical generator having a plurality of turns of wire forming a coil, a rotating magnet positioned in the coil, at least one stationary magnet positioned about the coil, and a slider movable relative to the rotating magnet in a direction tangential to an outer surface of the rotating magnet are provided. The slider can be configured to cause rotation of the rotating magnet, and the rotation of the rotating magnet and/or an interaction of the rotating magnet with a magnetic field of one or more of the at least one stationary magnet and the slider magnet can induce a voltage across a first terminal end and a second terminal end.

公开(公告)号：US11913071B2

公开(公告)日：2024-02-27

申请号：US18154630

申请日：2023-01-13

申请人： Singular Genomics Systems, Inc.

发明人： Daan Witters ,  Eli N. Glezer ,  Allen Lipson

IPC分类号： C12Q1/6869 ,  C12Q1/6834

CPC分类号： C12Q1/6869 ,  C12Q1/6834

摘要： Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.

公开(公告)号：US11884943B2

公开(公告)日：2024-01-30

申请号：US17494668

申请日：2021-10-05

申请人： Singular Genomics Systems, Inc.

发明人： Souad Naji ,  Eli N. Glezer ,  Youngjin Cho ,  Zachary Terranova ,  Abrehet Abdu

IPC分类号： C12N9/12 ,  C12N15/63 ,  C12Q1/68 ,  C12Q1/6874

CPC分类号： C12N9/1252 ,  C12N15/63 ,  C12Q1/6874 ,  C12Y207/07007

摘要： Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

公开(公告)号：US11878993B2

公开(公告)日：2024-01-23

申请号：US18295770

申请日：2023-04-04

申请人： Singular Genomics Systems, Inc

发明人： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC分类号： C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

摘要： Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11859244B2

公开(公告)日：2024-01-02

申请号：US18185786

申请日：2023-03-17

申请人： Singular Genomics Systems, Inc

发明人： Ryan Shultzaberger ,  Allen Lipson ,  Daan Witters

IPC分类号： C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6855

CPC分类号： C12Q1/6855 ,  C12Q1/6874 ,  C12Q1/6876

摘要： Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.

公开(公告)号：US11753678B2

公开(公告)日：2023-09-12

申请号：US18045913

申请日：2022-10-12

申请人： Singular Genomics Systems, Inc.

发明人： Eli N. Glezer

IPC分类号： C12Q1/6841

CPC分类号： C12Q1/6841

摘要： Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.

公开(公告)号：US11747262B2

公开(公告)日：2023-09-05

申请号：US17105330

申请日：2020-11-25

申请人： SINGULAR GENOMICS SYSTEMS, INC.

发明人： Sandor Kovacs ,  Anson Hsu ,  David Baranson ,  John Van Doorn ,  Eli N. Glezer

IPC分类号： G01N15/14 ,  G01N15/00

CPC分类号： G01N15/1404 ,  G01N15/147 ,  G01N2015/0076 ,  G01N2015/1402 ,  G01N2015/1497

摘要： The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.

公开(公告)号：US11723960B2

公开(公告)日：2023-08-15

申请号：US17181924

申请日：2021-02-22

申请人： Codexis, Inc.

发明人： David C. Schriemer ,  Martial Rey

IPC分类号： A61K38/48 ,  A61K36/185

CPC分类号： A61K38/488 ,  A61K36/185 ,  A61K38/48 ,  C12Y304/00 ,  C12Y304/23012

摘要： The invention described herein relates to methods and compositions for treatment of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity), or inhibition of inflammation and/or immune response in the intestine due to antigenic food peptides, by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.