公开(公告)号：US11698947B2

公开(公告)日：2023-07-11

申请号：US17965375

申请日：2022-10-13

Applicant: Hume AI Inc.

Inventor： Alan Cowen ,  Dacher Keltner ,  Bill Schoenfeld

IPC: G06F18/40 ,  A61B5/16 ,  G16H50/20 ,  G06F18/214 ,  G06N20/00

CPC classification number: G06F18/41 ,  A61B5/165 ,  G06F18/2148 ,  G16H50/20 ,  G06N20/00

Abstract: Embodiments of the present disclosure provide systems and methods for training a machine-learning model for predicting emotions from received media data. Methods according to the present disclosure include displaying a user interface. The user interface includes a predefined media content, a plurality of predefined emotion tags, and a user interface control for controlling a recording of the user imitating the predefined media content. Methods can further include receiving, from a user, a selection of one or more emotion tags from the plurality of predefined emotion tags, receiving the recording of the user imitating the predefined media content, storing the recording in association with the selected one or more emotion tags, and training, based on the recording, the machine-learning model configured to receive input media data and predict an emotion based on the input media data.

公开(公告)号：US11667681B2

公开(公告)日：2023-06-06

申请号：US17164018

申请日：2021-02-01

Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

Inventor： James V. Moroney ,  Marylou C. Machingura ,  Joanna N. Bajsa-Hirschel

IPC: C07K14/40 ,  C07K14/405 ,  C12N15/82 ,  C12N15/11

CPC classification number: C07K14/405 ,  C12N15/8271 ,  C12N15/11 ,  Y02A40/146

Abstract: Provided herein are green alga Cia8 polypeptides and the polynucleotides that encode them. Also provided herein are transformed cells and transgenic plants that include one or more of the polynucleotides and/or polypeptides provided herein.

公开(公告)号：US11413310B2

公开(公告)日：2022-08-16

申请号：US16616938

申请日：2018-06-01

Applicant: Juno Therapeutics, Inc.

Inventor： Tina Albertson ,  Brian Christin ,  Jacob Randolph Garcia ,  Christopher Glen Ramsborg ,  Claire L. Sutherland ,  Clinton Weber ,  Rachel K. Yost ,  Mark J. Gilbert ,  He Li

IPC: A61K35/17 ,  A61P35/00 ,  C07K14/73 ,  C07K14/705

Abstract: Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with non-Hodgkin lymphoma (NHL). In some embodiments, the methods are for treating subjects with relapsed or refractory NHL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.

公开(公告)号：US11319004B2

公开(公告)日：2022-05-03

申请号：US16493257

申请日：2018-02-26

Applicant: BAE Systems Hägglunds Aktiebolag

Inventor： Anders Sandin ,  Jonny Ljung ,  Ulf Wiberg

IPC: B62D55/108 ,  B60G11/08

Abstract: The invention relates to a tracked vehicle (V1, V2) comprising a vehicle body (20; 120), at least one track assembly (10) and a suspension device (S). Said track assembly (10) is arranged to be supported by said vehicle body (20; 120) by means of said suspension device (S). Said track assembly comprises a track support beam (12) for supporting a plurality of road wheels (16), an endless track (14) being disposed around said road wheels. Said suspension device (S) comprises a leaf spring arrangement (30; 130, 142, 144) having portions transversally arranged relative to the longitudinal extension of the vehicle. Said leaf spring arrangement comprises L-shaped leaf spring members (30; 130), each leaf spring member (30; 130) having a first portion (32; 132) attached to said vehicle body (20; 120), a second portion (34; 134) attached to said track support beam (12) and a transition portion (36; 136) there between, so that compressive and tensile stresses are located to said transition portion (36; 136) for generating a compressive action in said transition portion.

公开(公告)号：US11181803B2

公开(公告)日：2021-11-23

申请号：US16248589

申请日：2019-01-15

Applicant: ProLynx LLC

Inventor： Gary W. Ashley ,  Daniel V. Santi ,  Jeffrey C. Henise

IPC: A61K47/61 ,  G02F1/361 ,  A61K47/69 ,  A61K47/60 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L27/54 ,  A61L27/58 ,  C07C317/18 ,  C08J3/075 ,  C09B23/01 ,  A61K47/34 ,  A61L15/26 ,  A61L27/18 ,  A61L27/52 ,  C07C271/08

Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

公开(公告)号：US11022244B2

公开(公告)日：2021-06-01

申请号：US16078598

申请日：2017-02-08

Applicant: FUMEX AB

Inventor： Gustav Stenberg

IPC: F16L27/08 ,  F16L27/111 ,  F16L43/02 ,  B08B15/00

Abstract: A lockable friction joint includes a first joint member with a first arm member and a second joint member with a second arm member, the first and second joint members each having an inner friction surface and pivotal connecting projections. A friction adjustment device includes an adjustment element on an outer surface of the second joint member, and a fixating element on an outer surface of the first joint member. A plurality of friction discs are adjacent each other and between the inner friction surfaces of the first and second joint members, whereby friction between the friction discs is adjusted by the adjustment element. Each friction disc has at least one friction surface acting on an adjacent friction surface of another element of the friction joint and each friction disc is pivotally coupled to at least one other element of the friction joint.

公开(公告)号：US10743684B2

公开(公告)日：2020-08-18

申请号：US16049507

申请日：2018-07-30

Applicant: Lokendra Kumar

Inventor： Lokendra Kumar

IPC: A47G1/08

Abstract: An adjustable mechanical assembly system is disclosed. In some examples, the frame assembly system comprises a plurality of joining pieces having a plurality of openings in each joining piece, each of the plurality of openings having a first cross-sectional shape and framing pieces having a second cross-sectional shape, different from the first cross-sectional shape, wherein the first cross-sectional shape can be formed by an arrangement of two or more of the framing pieces, a first one of the two or more framing pieces positioned approximately perpendicular to at least a second one of the two or more framing pieces in the arrangement. In some examples, four joining pieces form four corners of a rectangular frame, and at least eight framing pieces form four sides of the rectangular frame. In some examples, the joining piece can further comprise a protruding member extending from the joining piece.

公开(公告)号：US10548975B2

公开(公告)日：2020-02-04

申请号：US15958295

申请日：2018-04-20

Applicant: Dynavax Technologies Corporation

Inventor： Gary S. Ott ,  Robert J. Milley ,  Robert L. Coffman ,  Radwan Kiwan ,  Holger Kanzler

IPC: C12N15/113 ,  A61K47/60 ,  A61K39/39 ,  C07H21/04 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  C07H21/00 ,  A61K47/61 ,  A61K39/00

Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

公开(公告)号：US10471060B2

公开(公告)日：2019-11-12

申请号：US16356895

申请日：2019-03-18

Applicant: Eli Lilly and Company

Inventor： Mengyang Fan ,  Luoheng Qin ,  Yi Wei ,  Guoqiang Zhou ,  Jingye Zhou

IPC: C07D471/10 ,  A61K31/506 ,  A61P1/16

Abstract: The present invention provides compounds of the formula below pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.

公开(公告)号：US10440941B2

公开(公告)日：2019-10-15

申请号：US14707673

申请日：2015-05-08

Applicant: Garrett Alan Hall

Inventor： Garrett Alan Hall

IPC: A01K95/02 ,  A01K95/00 ,  A01K91/03 ,  A01K97/00

Abstract: A reusable rock holder for use as a fishing sinker is disclosed. According to embodiments of the disclosure, instead of using a conventional fishing sinker in a fishing rig, the reusable rock holder can secure a rock or other object for use as a sinker. The reusable rock holder can secure rocks or objects having different or irregular shapes and/or sizes corresponding to materials naturally occurring in the environment. Furthermore, the reusable rock holder can release the rock or other object when snagged, allowing the fisherman to retrieve the rock holder and the rest of the fishing rig. The fisherman can then simply find another rock, secure it in the rock holder, and resume fishing. The availability of rocks at the fishing location can provide a zero-cost source of eco-friendly sinkers.