公开(公告)号：US09693980B2

公开(公告)日：2017-07-04

申请号：US15169617

申请日：2016-05-31

申请人： Infirst Healthcare Limited

发明人： Robin Mark Bannister ,  John Brew ,  Wilson Caparros-Wanderley ,  Gregory Alan Stoloff ,  Suzanne Jane Dilly ,  Gemma Szucs ,  Olga Pleguezuelos Mateo

IPC分类号： A61K31/60 ,  A61K31/19 ,  A61K31/192 ,  A61K9/08 ,  A61K47/44 ,  A61K9/20 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K31/215 ,  A61K31/22 ,  A61K31/40 ,  A61K31/216

CPC分类号： A61K31/192 ,  A61K9/08 ,  A61K9/2013 ,  A61K31/19 ,  A61K31/196 ,  A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/40 ,  A61K31/60 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/44 ,  Y02A50/463

摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.

公开(公告)号：US09689372B2

公开(公告)日：2017-06-27

申请号：US14507619

申请日：2014-10-06

申请人： Aurelio Izquierdo Gonzalez

发明人： Aurelio Izquierdo Gonzalez

IPC分类号： F03D3/04 ,  F03D3/00 ,  F03D7/06 ,  F03D9/00 ,  F03D80/30 ,  F03D9/25

CPC分类号： H02S10/12 ,  F03D3/005 ,  F03D3/0418 ,  F03D3/0436 ,  F03D7/06 ,  F03D9/25 ,  F03D15/10 ,  F03D80/30 ,  F05B2240/13 ,  F05B2270/1011 ,  Y02E10/74

摘要： A vertical-axis wind turbine apparatus is disclosed. In at least one embodiment, the apparatus provides a substantially vertically-oriented main shaft. A blade assembly is coaxially aligned with and rotatably engaged about the main shaft. The blade assembly provides an at least one blade radially projecting therefrom. A housing is rotatably engaged with the main shaft and configured for selectively encompassing the blade assembly. A first screen is integral with the housing and configured for shielding a return portion of the blade assembly. A second screen is rotatably engaged with the housing and configured for selectively moving between a retracted position, wherein the second screen is positioned substantially adjacent to the first screen such that a catch portion of the blade assembly is exposed, and a deployed position, wherein the second screen is rotated away from the first screen for at least partially shielding the catch portion from the wind.

公开(公告)号：US09688989B2

公开(公告)日：2017-06-27

申请号：US14405776

申请日：2013-06-10

申请人： SENSORION

发明人： Éric Wersinger

IPC分类号： A61K31/497 ,  C12N15/113 ,  A61K31/454 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7105 ,  A61K31/713

CPC分类号： C12N15/1138 ,  A61K31/454 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7105 ,  A61K31/713 ,  C12N2310/10

摘要： The invention relates to Histamine type 4 receptor (H4R) inhibitors for treating tinnitus.

公开(公告)号：US09688615B2

公开(公告)日：2017-06-27

申请号：US14833601

申请日：2015-08-24

申请人： Mark G. DeGiacomo

发明人： Hassan Pajouhesh ,  Richard Holland ,  Lingyun Zhang ,  Hossein Pajouhesh ,  Jason Lamontagne ,  Brendan Whelan

IPC分类号： C07D207/16 ,  C07D205/04 ,  C07D265/30 ,  C07D231/14 ,  C07D211/60 ,  C07C237/04 ,  C07C237/06 ,  C07C237/22 ,  C07C237/24 ,  C07D235/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D401/12 ,  C07D413/06 ,  C07D241/08

CPC分类号： C07C237/06 ,  C07C237/04 ,  C07C237/22 ,  C07C237/24 ,  C07C2601/02 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D231/14 ,  C07D235/14 ,  C07D241/08 ,  C07D265/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06

摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

公开(公告)号：US09675686B2

公开(公告)日：2017-06-13

申请号：US14656690

申请日：2015-03-12

申请人： PepTcell, Ltd.

发明人： Gregory Alan Stoloff ,  Wilson Romero Caparros-Wanderlay

IPC分类号： A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/55544 ,  C07K14/005 ,  C07K2319/01 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16322 ,  C12N2740/16334

摘要： The present specification discloses an immunogenic composition comprising polypeptide, wherein each of the polypeptides has no more than 100 amino acids, which polypeptides comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope,wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.

公开(公告)号：US09672532B2

公开(公告)日：2017-06-06

申请号：US15243350

申请日：2016-08-22

申请人： Cynthia Fascenelli Kirkeby

发明人： Cynthia Fascenelli Kirkeby

IPC分类号： G06F17/00 ,  H04L29/06 ,  G06Q30/02 ,  H04L29/08 ,  G06F21/10 ,  G06Q30/00 ,  G06Q20/12

CPC分类号： G06Q30/0263 ,  G06F21/10 ,  G06Q20/123 ,  G06Q30/00 ,  H04L63/08 ,  H04L63/10 ,  H04L63/20 ,  H04L67/06

摘要： The monetization of downloadable files associated with a custodial host site based on resolving custodianship to a referrer publisher with subsequent presentation of monetized content within a modal overlay is disclosed. A request from a client device has a resource identifier and a referrer publisher identifier. The request for the downloadable file is evaluated against one or more publisher and custodianship policy rules, which relate to a file extension of the downloadable file, a format of the resource identifier, a custodial domain on which the downloadable file is stored, and a referral domain as specified in the referrer publisher identifier. When custodianship is resolved, a modal overlay on which monetized content is incorporated is presented on the client device. The modal overlay is concurrently displayed with the transfer of the downloadable file to the client device.

公开(公告)号：US09615585B2

公开(公告)日：2017-04-11

申请号：US14776330

申请日：2014-03-14

申请人： National Center for Scientific Research “Demokritos”

发明人： Kostas Iatrou ,  Patrick Guerin ,  Thomas Kröber ,  Maria Konstantopoulou

IPC分类号： A01N65/00 ,  A01N65/22 ,  A01N31/04 ,  A01N31/08 ,  A01N35/04 ,  A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N31/00 ,  A01N65/10 ,  G01N33/566 ,  A61K36/53

CPC分类号： A01N65/22 ,  A01N31/00 ,  A01N31/04 ,  A01N31/08 ,  A01N35/02 ,  A01N35/04 ,  A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N65/00 ,  A01N65/10 ,  A61K36/53 ,  G01N33/566 ,  G01N2333/43591 ,  Y02A50/322 ,  Y02A50/326 ,  Y02A50/327 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/411 ,  A01N65/24

摘要： The present specification discloses natural repellent compounds, and isomeric forms, structural analogs and derivatives of the said compounds, having repellent activity against mosquitoes and other blood-sucking arthropods, compositions comprising such repellent compounds, methods of screening for such repellent compounds, methods of reducing mosquito bites on an individual and methods of reducing mosquito infestation to a location.

公开(公告)号：US09585887B2

公开(公告)日：2017-03-07

申请号：US14723225

申请日：2015-05-27

申请人： Tangent Reprofiling Limited

发明人： Suzanne Dilly ,  Gregory Stoloff ,  Paul Taylor

IPC分类号： A61K31/517 ,  A61K31/42 ,  A61K31/20 ,  A61K31/519 ,  A61K31/201 ,  A61K45/06 ,  A61K31/454

CPC分类号： A61K31/519 ,  A61K31/201 ,  A61K31/454 ,  A61K45/06 ,  A61K2300/00

摘要： The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.

公开(公告)号：US09486510B2

公开(公告)日：2016-11-08

申请号：US14447556

申请日：2014-07-30

申请人： Lipoxen Technologies Limited

发明人： Andrew David Bacon ,  Peter Laing ,  Gregory Gregoriadis ,  Wilson Romero Caparros-Wanderley

IPC分类号： A61K9/48 ,  A61K39/00 ,  A61K39/12 ,  A61K39/02 ,  C07H21/04 ,  A61K39/145 ,  C12N7/00 ,  A61K39/29 ,  A61K39/39

CPC分类号： A61K9/1277 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/70 ,  C07H21/04 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2760/16134

摘要： A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.

摘要翻译： 一种组合物，其包含与可操作地编码抗原性蛋白质和蛋白质蛋白质的核酸相关联的脂质体，其中所述组合物蛋白质与所述抗原蛋白质共享至少一个表位，并且其中所述核酸和所述组合物蛋白质与相同的脂质体相关联 描述。 与脂质体的混合物相比，组合物提供了改善的免疫应答，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

公开(公告)号：US09474805B2

公开(公告)日：2016-10-25

申请号：US14720700

申请日：2015-05-22

申请人： Lipoxen Technologies Limited

发明人： Sanjay Jain ,  Peter Laing ,  Gregory Gregoriadis

IPC分类号： A01N37/18 ,  A61K38/00 ,  C07K1/00 ,  A61K38/16 ,  C07K14/00 ,  A61K47/48 ,  A61K38/18 ,  C07K14/535 ,  C07K14/52 ,  C07K14/505 ,  C07K14/575 ,  A61K38/46 ,  A61K38/19

CPC分类号： A61K47/61 ,  A61K38/00 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/465 ,  C07K14/505 ,  C07K14/52 ,  C07K14/535 ,  C07K14/575 ,  C12N9/22 ,  C12Y301/21001 ,  Y02A50/473

摘要： The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.