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1.发明授权Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging 有权包含与用于神经成像的病毒组分相关的荧光染料的成像方法和组合物公开(公告)号：US08361775B2
公开(公告)日：2013-01-29
申请号：US12466122
申请日：2009-05-14
申请人： Robert W. Flower
发明人： Robert W. Flower
CPC分类号： A61K49/0056 , A61K35/76 , A61K35/763 , A61K47/6901 , A61K49/0021 , A61K49/0034 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0097
摘要： Disclosed herein are compositions and methods for imaging nerve cells. The composition comprises a fluorescent dye; and a viral component selected from a neurotropic, replication-defective virus, a viral protein of a neurotropic virus, and a capsid of a neurotropic virus. Although the fluorescent dye in itself cannot penetrate nerve cells, the fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells.
摘要翻译： 本文公开了用于成像神经细胞的组合物和方法。 该组合物包含荧光染料; 以及选自神经营养性复制缺陷型病毒，神经营养性病毒的病毒蛋白质和神经营养性病毒衣壳的病毒成分。 虽然荧光染料本身不能穿透神经细胞，荧光染料与病毒组分结合形成能够穿透神经细胞的染料/病毒组分复合物。
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公开(公告)号：US08313917B2
公开(公告)日：2012-11-20
申请号：US12811435
申请日：2008-12-29
申请人： Geoffrey Schmidt
发明人： Geoffrey Schmidt
IPC分类号： G01N33/00
CPC分类号： G01N33/574 , G01N2333/4719
摘要： Disclosed are procedures and methods for diagnosing latent and active cancers in a subject. The described methods include the use of sandwich ELISA assays containing antibodies specific for certain epitopes on the A-protein. This enables the assay to discriminate between the monomelic and homopolymeric forms of A-protein.
摘要翻译： 公开了用于诊断受试者中潜伏和活跃癌症的程序和方法。 所描述的方法包括使用含有针对A蛋白上的某些表位特异性抗体的夹心ELISA测定。 这使得测定能够区分A蛋白的单体和均聚形式。
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3.发明授权Container for a medical instrument or implant, in particular a dental instrument or a dental implant 有权用于医疗器械或植入物的容器，特别是牙科器械或牙科植入物公开(公告)号：US08181773B2
公开(公告)日：2012-05-22
申请号：US12843221
申请日：2010-07-26
申请人： Daniel Guenter , Rainer Bammerlin
发明人： Daniel Guenter , Rainer Bammerlin
IPC分类号： A61B19/02
CPC分类号： A61C8/0087 , A61C8/0089 , A61C2202/00
摘要： Container for a medical instrument or an implant, in particular a dental instrument or a dental implant (14), the container having an outer housing part (16), and an inner housing part (18) which is movable relative to the outer housing part (16) from a closed position to an open position. The inner housing part (18) has a grip element (44) accessible from the outside. The container has a locking mechanism (22), which acts between the outer housing part (16) and the inner housing part (18), and an actuation of the grip element (44) causes an unlocking of the locking mechanism (22).
摘要翻译： 用于医疗器械或植入物的容器，特别是牙科器械或牙科植入物（14），所述容器具有外部壳体部分（16）和内部壳体部分（18），其可相对于所述外部壳体部分 （16）从关闭位置到打开位置。 内壳体部分（18）具有从外部可接近的抓握元件（44）。 容器具有作用在外部壳体部分（16）和内部壳体部分（18）之间的锁定机构（22），并且夹紧元件（44）的致动导致锁定机构（22）的解锁。
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公开(公告)号：USD659551S1
公开(公告)日：2012-05-15
申请号：US29406555
申请日：2011-11-16
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公开(公告)号：US08152848B2
公开(公告)日：2012-04-10
申请号：US12259608
申请日：2008-10-28
IPC分类号： A61F2/28
CPC分类号： A61B17/68 , A61B17/80 , A61C8/0006 , A61L27/32 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/412 , A61L2430/02
摘要： A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to obtain autologous bone. The implant has an apical portion that is fastened into existing bone, with the remainder of the implant left outside of existing bone. The exposed portion of the implant may have an external shape or configuration with a variety of attached and/or integrally formed mechanical retention and stability elements. Osteotropic/angiotropic material may be associated with the implant to induce and or conduct new bone growth and possible vascularization, thus, rather than fitting the implant into the bone, the bone is grown integratively with the implant. The osteotropic/angiotropic materials may be simultaneously placed with the staged implant to provide consistent stabilization for the materials and to provide an immediately available surface for bone cell adhesion and growth. The invention thus allows implants to be used in location where the volume and/or shape of the bone would not be adequate for existing implant systems.
摘要翻译： 结构/生物植入物和使用方法。 植入物被用作单阶段或多阶段的系统，其被设计成鼓励新牙槽骨生长有或没有需要获得自体骨。 植入物具有固定到现有骨中的顶端部分，其余的植入物留在现有骨骼的外部。 植入物的暴露部分可以具有外部形状或结构，其具有各种附接和/或整体形成的机械保持和稳定性元件。 骨质/潜伏性物质可能与植入物相关联以诱导和/或引起新的骨生长和可能的血管形成，因此，不是将植入物装配到骨中，骨与植入物一体生长。 可以将骨/注射材料同时放置于分段植入物中，以为材料提供一致的稳定性，并为骨细胞粘附和生长提供立即可用的表面。 因此，本发明允许将植入物用于骨的体积和/或形状对于现有的植入物系统是不够的。
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公开(公告)号：US08137091B2
公开(公告)日：2012-03-20
申请号：US12251104
申请日：2008-10-14
IPC分类号： B29C49/12
CPC分类号： B29C49/12 , B29C49/06 , B29C49/42 , B29C49/56 , B29C2049/1204 , B29L2031/774
摘要： A stretching rod holding arrangement may include a stretching rod for expanding plastic containers, wherein the stretching rod has an elongate rod-shaped main body and a holding body, which protrudes with respect to this rod-shaped main body in a radial direction of the rod-shaped main body. The arrangement comprises a receiving space for mounting the stretching rod, wherein at least one region of the holding body can be received by this receiving space, and the receiving space has a lower boundary wall in the longitudinal direction of the stretching rod. An opening is provided in this lower boundary wall, through which opening the main body of the stretching rod can pass. An arresting mechanism, which can be moved with respect to the receiving space between at least two positions, may be provided above the lower boundary wall in the longitudinal direction of the stretching rod. In the first position, the arresting mechanism allows the passage of the holding body in the longitudinal direction of the stretching rod, and in the second position prevents the passage of the holding body of the stretching rod.
摘要翻译： 拉伸杆保持装置可以包括用于扩展塑料容器的拉伸杆，其中拉伸杆具有细长的杆状主体和保持体，该杆在主体的径向方向上相对于该棒状主体突出 形主体。 该装置包括用于安装拉伸杆的容纳空间，其中保持体的至少一个区域可被该容纳空间容纳，并且容纳空间在拉伸杆的纵向具有下边界壁。 在该下边界壁上设有开口，拉伸杆的主体通过该开口可以通过。 可以在拉伸杆的纵向方向上的下边界壁的上方设置能够在至少两个位置之间相对于收容空间移动的止动机构。 在第一位置，止动机构允许保持体在拉伸杆的纵向方向上通过，并且在第二位置防止拉伸杆的保持体的通过。
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7.发明授权Systemic purine administration: modulating axonal outgrowth of central nervous system neurons 失效系统性嘌呤给药：调节中枢神经系统的轴突生长公开(公告)号：US08133861B2
公开(公告)日：2012-03-13
申请号：US12393419
申请日：2009-02-26
CPC分类号： A61K31/7076 , A61K9/0019 , A61K31/708 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： Methods for modulating the axonal outgrowth of central nervous system neurons are provided by means of internalized purine administration such as by intravenous, intraarterial, subcutaneous, intramuscular, intraperitoneal, and intrapleural administration. The methods are noted for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, traumatic brain injury, cerebral aneurism, spinal cord injury and the like).
摘要翻译： 通过静脉内，动脉内，皮下，肌内，腹膜内和胸膜内施用的内在嘌呤给药来提供调节中枢神经系统神经元的轴突生长的方法。 注意到用于刺激中枢神经系统神经元在损伤（例如中风，创伤性脑损伤，脑动脉瘤，脊髓损伤等）之后的轴突生长的方法。
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8.发明授权Reversibly gelling polyurethane composition for surgical repair and augmentation 有权反射胶凝聚氨酯组合物进行手术修复和增强公开(公告)号：US08114157B2
公开(公告)日：2012-02-14
申请号：US12162039
申请日：2007-01-24
IPC分类号： A61F2/00
摘要： A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.
摘要翻译： 描述了新的可逆胶凝聚氨酯（RGP）聚合物组合物，以及其制备的新方法及其用于填充组织或膨胀组织中的空间或恢复器官功能的医疗用途。 新型RGP聚合物在静置时形成凝胶，在剪切过程中液化并在剪切后可立即重新形成宏观凝胶。 使用的方法包括将改进的凝胶递送到身体上的部位以填充空隙或增加局部组织体积。
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9.发明授权公开(公告)号：US08097269B2
公开(公告)日：2012-01-17
申请号：US11463237
申请日：2006-08-08
IPC分类号： A61F2/02
CPC分类号： A61L31/088 , A61L27/306 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/608 , C08L83/04
摘要： Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
摘要翻译： 公开了使用用作生物活性材料储存器的溶胶 - 凝胶组合物涂层的植入式医疗装置，以及使用溶胶 - 凝胶组合物涂层来改善有机和无机基材的粘附性。
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公开(公告)号：US08071204B2
公开(公告)日：2011-12-06
申请号：US12863813
申请日：2008-12-15
IPC分类号： B32B25/02
CPC分类号： B32B27/12 , B29C70/025 , B29C70/465 , B32B5/26 , B32B38/08 , B32B2038/0076 , B32B2305/076 , B32B2307/3065 , C08J5/10 , C08J5/24 , Y10T428/249939 , Y10T428/24994 , Y10T428/249941 , Y10T428/24995 , Y10T428/25
摘要： Prepeg for manufacturing a fiber-reinforced composite material, the prepreg comprising a layer of dry fibers and a layer of resin material adhered to a surface of the layer of dry fibers, the resin material having a plurality of particles dispersed therein, the particles have an average particle size that is larger than the average fiber separation of the layer of dry fibers.
摘要翻译： 用于制造纤维增强复合材料的Prepeg，所述预浸料包括干纤维层和粘附到干纤维层的表面的树脂材料层，所述树脂材料具有分散在其中的多个颗粒，所述颗粒具有 平均粒径大于干纤维层的平均纤维分离。
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