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公开(公告)号：US20250029978A1
公开(公告)日：2025-01-23
申请号：US18222627
申请日：2023-07-17
Applicant: Academia Sinica
Inventor： Maw-Kuan WU , Yu-Hsuan SU , Chin-Yi CHUNG , Yan-Reui CHEN , Feng-Yu WU , Po-Wei CHI , Phillip M. WU
IPC: H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/62 , H01M10/0525
Abstract: An electrode for a lithium-ion battery is provided, which comprises: a current collector; and an electrode material layer disposed on the current collector, wherein the electrode material layer comprises an anode material and a binder, the binder is pectin, its derivative or a combination thereof, and the anode material is selected from the group consisting of lithium vanadium oxide, lithium titanium oxide, lithium iron oxide, graphite, and a combination thereof. In addition, a lithium-ion battery comprising the aforesaid electrode is also provided.
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公开(公告)号：US12178870B2
公开(公告)日：2024-12-31
申请号：US18662436
申请日：2024-05-13
Applicant: ACADEMIA SINICA
Inventor： Chi-Huey Wong , Hsin-Yu Liao , Shih-Chi Wang , Yi-An Ko , Kuo-I Lin , Che Ma , Ting-Jen Cheng
IPC: A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/16 , C07K14/005 , C07K14/11
Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
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公开(公告)号：US12171729B2
公开(公告)日：2024-12-24
申请号：US17779048
申请日：2020-11-25
Applicant: The Johns Hopkins University , Academia Sinica , National Yang Ming Chiao Tung University
Inventor： Ru Chih C. Huang , Jong Ho Chun , Yu-Ling Lin , Yu-Chuan Liang , Kuang-Wen Liao , Tiffany Jackson , David Mold , Chien-Hsien Lai
IPC: A61K31/05 , A61K9/00 , A61K31/09 , A61K31/444 , A61K31/495 , A61K47/14 , A61K47/22 , A61P35/00
Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.
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公开(公告)号：US20240420944A1
公开(公告)日：2024-12-19
申请号：US18701598
申请日：2022-10-12
Applicant: Academia Sinica
Inventor： Yi-Sheng WANG , Yi-Hong CAI
Abstract: Provided herein are designs of a linear time-of-flight (TOF) mass spectrometer that achieves a high mass resolving power (MRP) to ions independently having a mass-to-charge (m/z) ratio between 1,000 and 100,000. The TOF mass spectrometer comprises an ion source, a flight tube, and an ion detector, in which the ion source comprises a sample plate, an extraction plate disposed at a first distance (d1) away from the sample plate; an end plate disposed at a second distance (d2) away from the extraction plate; a first electric field (e1) present between the sample plate and the extraction plate; and a second electric field (e2) present between the extraction plate and the end plate; the flight tube having a length of d3 is disposed downstream and adjacent to the ion source; and the ion detector is disposed downstream and adjacent to the flight tube; and the linear TOF mass spectrometer satisfies the set of criteria I or II, in which the set of criteria I includes (1) d1/L
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公开(公告)号：US12157763B2
公开(公告)日：2024-12-03
申请号：US18403419
申请日：2024-01-03
Applicant: ACADEMIA SINICA
Inventor： Kuo-I Lin , Che Ma , Chi-Huey Wong , Szu-Wen Wang , Yi-Hsuan Chang , Xiaorui Chen , Han-Yi Huang
Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
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Patent Agency Ranking
公开(公告)号：US12144822B2
公开(公告)日：2024-11-19
申请号：US17043891
申请日：2019-04-02
Applicant: Academia Sinica
Inventor： Jun-An Chen , Kuan-Chih Peng , Ying-Tsen Tung
IPC: C07H21/02 , A61K31/7105 , A61K47/46 , A61P21/00 , A61P25/00 , C12N15/113
Abstract: The present disclosure relates to mir-17˜92 as a candidate therapeutic or diagnostic target of motor neuron (MN) degeneration diseases. Expression of mir-17˜92 is sustained throughout adulthood in spinal MNs and specifically decreases before the onset of MN loss in SOD1G93A mice. Accordingly, mir-17˜92 can be used as a candidate therapeutic target for ALS.
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公开(公告)号：US12129273B2
公开(公告)日：2024-10-29
申请号：US18227782
申请日：2023-07-28
Applicant: Academia Sinica
Inventor： Chih-Cheng Chen , Jim-Min Fang , Cheng-Han Lee , Jen-Yao Chang
IPC: C07H19/16 , A61K31/7076 , A61K38/04 , A61K47/55 , A61P29/00
CPC classification number: C07H19/16 , A61K31/7076 , A61K38/046 , A61K47/55 , A61P29/00
Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.
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公开(公告)号：US20240347203A1
公开(公告)日：2024-10-17
申请号：US18299051
申请日：2023-04-12
Inventor： Hao-Min Cheng , Yeong-Sung Lin , Yennun Huang , Chiu-Han Hsiao , Po-Chun Yu , Chia-Ying Hsieh , Wei-Lun Chang
Abstract: Methods and computer-implemented methods are used to predict a risk of cardiovascular disease by using a machine learning mode to analyze a relationship between the occurrence of cardiovascular disease and the health data of patients.
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公开(公告)号：US20240219704A1
公开(公告)日：2024-07-04
申请号：US18608479
申请日：2024-03-18
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
CPC classification number: G02B21/365 , G02B21/06 , G02B21/26 , G06V10/141 , G06V10/25 , G06V20/693 , H04N23/56 , H04N23/74
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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10.发明公开公开(公告)号：US20240196931A1
公开(公告)日：2024-06-20
申请号：US18286943
申请日：2022-04-14
Applicant: ACADEMIA SINICA
Inventor： Lie-Fen SHYUR , Yu-Chuan LIANG , Wen-Yuh LIN , Chin-Ting CHANG , Meng-Ting CHANG , Yu-Hsin CHEN
Abstract: Provided is an animal feed composition including a plant-based feed additive. Also provided is a method for promoting overall health condition of an animal, including increase of feed efficiency and decrease of feed converting rate, increase of probiotics and decrease of pathogens in gut microbiota of pigs, anti-inflammation, affecting primary metabolism, promoting growth and survival rate, and preventing or treating diseases caused by pathogenic bacteria, porcine reproductive and respiratory syndrome virus (PRRSV).
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