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1.发明申请AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS 有权作为组胺H3受体拮抗剂的AZETIDINES和CYCLOBUTANES公开(公告)号：US20110105459A1
公开(公告)日：2011-05-05
申请号：US12991225
申请日：2009-05-05
IPC分类号： A61K31/551 , C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14 , A61P29/00 , A61P3/00 , A61P9/00 , A61P1/00 , A61P11/02 , A61P11/06 , A61P25/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/06 , C07D403/14 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
摘要翻译： 本发明涉及其中R，R 0，R 1，m，n和X 1至X 4具有如在说明书和权利要求书中引用的含义的式（I）化合物。 所述化合物可用作组胺H3受体拮抗剂。 本发明还涉及药物组合物，这种化合物的制备以及作为药物的生产和使用。
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公开(公告)号：US20120040952A1
公开(公告)日：2012-02-16
申请号：US13147337
申请日：2010-01-29
IPC分类号： A61K31/551 , C07D401/14 , C07D403/12 , C07D413/14 , C07D405/14 , A61P11/06 , A61P25/00 , A61P9/00 , A61P1/00 , A61P25/30 , A61P11/02 , A61P37/08 , C07D403/06 , C07D417/14
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14
摘要： The invention relates to compounds of formula (I), wherein R, R1, m, n and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
摘要翻译： 本发明涉及式（I）化合物，其中R，R 1，m，n和X 1至X 3具有在说明书和权利要求书中引用的含义。 所述化合物可用作组胺H3受体拮抗剂。 本发明还涉及药物组合物，这种化合物的制备以及作为药物的生产和使用。
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公开(公告)号：US08912176B2
公开(公告)日：2014-12-16
申请号：US13147337
申请日：2010-01-29
IPC分类号： A61K31/551 , C07D243/08 , C07D413/14 , C07D403/14 , C07D405/14
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14
摘要： The invention relates to compounds of formula (I), wherein R, R1, m, n and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
摘要翻译： 本发明涉及式（I）化合物，其中R，R 1，m，n和X 1至X 3具有在说明书和权利要求书中引用的含义。 所述化合物可用作组胺H3受体拮抗剂。 本发明还涉及药物组合物，这种化合物的制备以及作为药物的生产和使用。
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公开(公告)号：US08691804B2
公开(公告)日：2014-04-08
申请号：US12991225
申请日：2009-05-05
IPC分类号： A01N31/00 , C07D243/08 , C07D403/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/06 , C07D403/14 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. These compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
摘要翻译： 本发明涉及其中R，R 0，R 1，m，n和X 1至X 4具有如在说明书和权利要求书中引用的含义的式（I）化合物。 这些化合物可用作组胺H3受体拮抗剂。 本发明还涉及药物组合物，这种化合物的制备以及作为药物的生产和使用。
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公开(公告)号：US08349831B2
公开(公告)日：2013-01-08
申请号：US11977777
申请日：2007-10-25
申请人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
发明人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
IPC分类号： A61K31/5377 , A61K31/137 , C07C211/29 , A61P13/12 , A61P9/00 , C07D401/04
CPC分类号： C07D261/18 , C07C211/29 , C07C217/58 , C07C233/43 , C07C233/44 , C07C233/80 , C07C271/28 , C07C311/37 , C07C317/32 , C07C323/32 , C07C2601/08 , C07C2601/16 , C07D207/06 , C07D207/09 , C07D207/48 , C07D211/22 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/60 , C07D235/06 , C07D237/14 , C07D239/42 , C07D249/08 , C07D261/08 , C07D263/24 , C07D263/34 , C07D271/06 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/205 , C07D295/26 , C07D307/68 , C07D317/58 , C07D333/38 , C07D333/40 , C07D409/04 , C07D413/12 , C07D417/04
摘要： The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
摘要翻译： 本发明一般涉及式I所示的化合物，包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。 本发明还涉及制备这些化合物和在这些方法中有用的中间体的方法。
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6.发明申请TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS 审中-公开作为组胺H3受体拮抗剂的四氢萘啶和其衍生物公开(公告)号：US20110046130A1
公开(公告)日：2011-02-24
申请号：US12935293
申请日：2009-03-27
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/519 , C07D471/14 , A61K31/5355 , A61P29/00 , A61P9/00 , A61P11/06 , A61P11/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein X1a, X1 to X5, Ra, Rb, n and R have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
摘要翻译： 本发明涉及式（I）化合物，其中X1a，X1至X5，Ra，Rb，n和R具有在说明书和权利要求书中引用的含义。 所述化合物可用作组胺H3受体拮抗剂。 本发明还涉及药物组合物，这种化合物的制备以及作为药物的生产和使用。
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公开(公告)号：US20080221101A1
公开(公告)日：2008-09-11
申请号：US11977777
申请日：2007-10-25
申请人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
发明人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
IPC分类号： A61K31/5377 , C07C211/29 , A61K31/137 , A61P13/12 , A61P9/00 , C07D401/04
CPC分类号： C07D261/18 , C07C211/29 , C07C217/58 , C07C233/43 , C07C233/44 , C07C233/80 , C07C271/28 , C07C311/37 , C07C317/32 , C07C323/32 , C07C2601/08 , C07C2601/16 , C07D207/06 , C07D207/09 , C07D207/48 , C07D211/22 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/60 , C07D235/06 , C07D237/14 , C07D239/42 , C07D249/08 , C07D261/08 , C07D263/24 , C07D263/34 , C07D271/06 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/205 , C07D295/26 , C07D307/68 , C07D317/58 , C07D333/38 , C07D333/40 , C07D409/04 , C07D413/12 , C07D417/04
摘要： The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
摘要翻译： 本发明一般涉及式I所示的化合物，包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。 本发明还涉及制备这些化合物和在这些方法中有用的中间体的方法。
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