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公开(公告)号:US10983083B2
公开(公告)日:2021-04-20
申请号:US15623662
申请日:2017-06-15
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
IPC分类号: G01N27/403 , G01N27/327 , G01N27/28 , G01N33/50
摘要: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
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公开(公告)号:US10413228B2
公开(公告)日:2019-09-17
申请号:US15436261
申请日:2017-02-17
申请人: AgaMatrix, Inc.
发明人: Sridhar G. Iyengar , Ian S. Harding
IPC分类号: G01N27/327 , A61B5/1495 , G01N27/26 , A61B5/1468 , G01N17/02 , A61B5/1473 , A61B5/00
摘要: A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.
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公开(公告)号:US20180088071A1
公开(公告)日:2018-03-29
申请号:US15830897
申请日:2017-12-04
申请人: AgaMatrix, Inc.
发明人: Steven Diamond , Martin Forest , Baoguo Wei , Ian Harding , Sridhar Iyengar
IPC分类号: G01N27/327 , B01L3/00
CPC分类号: G01N27/3272 , B01L3/5023 , B01L3/545 , B01L2300/02
摘要: A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing or deposition of the paths.
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公开(公告)号:US20170350847A1
公开(公告)日:2017-12-07
申请号:US15623662
申请日:2017-06-15
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
IPC分类号: G01N27/28 , G01N27/403 , G01N27/327 , G01N33/50
CPC分类号: G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
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公开(公告)号:US20160245776A1
公开(公告)日:2016-08-25
申请号:US15144024
申请日:2016-05-02
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar G. Iyengar
IPC分类号: G01N27/403 , G01N27/327
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/30 , G01N27/3272 , Y10T29/49002 , Y10T29/49114 , Y10T29/49117 , Y10T156/1052 , Y10T156/1062 , Y10T156/1074
摘要: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.
摘要翻译: 通过将具有结合开口的电阻片粘附到第一导电片上,精确地和精确地制造电化学测试电池。 然后通过电阻片和第一导电片冲切开切口。 开槽开口与电阻薄片中的第一个开口相交,并将第一个结合开口转变成电阻薄片中的凹口。 第二导电片被冲压成具有与第一导电片相对应的开槽开口,并且其粘接到电阻片的另一侧,使得开槽开口对准。 这种结构从周围的材料上被切割成一个电化学电池,该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。
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公开(公告)号:US20160192871A1
公开(公告)日:2016-07-07
申请号:US15069071
申请日:2016-03-14
申请人: AgaMatrix, Inc.
发明人: Sridhar Iyengar , Ian Harding
IPC分类号: A61B5/1486 , A61B5/00
CPC分类号: A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7225 , C12Q1/001 , C12Q1/006
摘要: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.
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公开(公告)号:US09234862B2
公开(公告)日:2016-01-12
申请号:US14278299
申请日:2014-05-15
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Richard Williams , Sridhar Iyengar
IPC分类号: G01N27/327 , G01N27/30 , C12Q1/00
CPC分类号: G01N27/3274 , C12Q1/006 , G01N27/307 , G01N27/327 , G01N27/3272 , G01N27/3273
摘要: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
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公开(公告)号:US20140262778A1
公开(公告)日:2014-09-18
申请号:US14291990
申请日:2014-05-30
申请人: AgaMatrix, Inc.
发明人: Ian Harding , Sridhar G. Iyengar
IPC分类号: G01N27/403
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/30 , G01N27/3272 , Y10T29/49002 , Y10T29/49114 , Y10T29/49117 , Y10T156/1052 , Y10T156/1062 , Y10T156/1074
摘要: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.
摘要翻译: 通过将具有结合开口的电阻片粘附到第一导电片上,精确地和精确地制造电化学测试电池。 然后通过电阻片和第一导电片冲切开切口。 开槽开口与电阻薄片中的第一个开口相交,并将第一个结合开口转变成电阻薄片中的凹口。 第二导电片被冲压成具有与第一导电片相对应的开槽开口,并且其粘接到电阻片的另一侧,使得开槽开口对准。 这种结构从周围的材料上被切割成一个电化学电池,该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。
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公开(公告)号:US20140001045A1
公开(公告)日:2014-01-02
申请号:US14010792
申请日:2013-08-27
申请人: AgaMatrix, Inc.
发明人: Ian Harding
IPC分类号: G01N27/30
摘要: An electrochemical test device is provided having a base layer with a first electrode thereon and a top layer with a second electrode thereon. The two electrodes are separated by a spacer layer having an opening therein, such that a sample-receiving space is defined with one electrode on the top surface, the other electrodes on the bottom surface and side walls formed from edges of the opening in the spacer. Reagents for performing the electrochemical reaction are deposited on one of the electrodes and on the side walls of the sample-receiving space.
摘要翻译: 提供一种电化学测试装置,其具有其上具有第一电极的基底层和其上具有第二电极的顶层。 两个电极由其中具有开口的间隔层隔开,使得样品接收空间被限定在顶表面上的一个电极,底表面上的另一电极和由间隔件中的开口的边缘形成的侧壁 。 用于进行电化学反应的试剂沉积在样品接收空间的一个电极和侧壁上。
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公开(公告)号:US20130118921A1
公开(公告)日:2013-05-16
申请号:US13723713
申请日:2012-12-21
申请人: AGAMATRIX, INC.
发明人: Ian Harding , Richard Williams , Sridhar Iyengar
IPC分类号: G01N27/327
CPC分类号: G01N27/3274 , C12Q1/006 , G01N27/307 , G01N27/327 , G01N27/3272 , G01N27/3273
摘要: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
摘要翻译: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正,并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。
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