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![MALEATE SALT OF THE FREE BASE OF N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)-PHENYL]-ACETAMIDE, PHARMACEUTICAL FORMULATIONS, METHODS OF MANUFACTURE AND USES THEREOF](/abs-image/US/2024/10/24/US20240350468A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240350468A1
公开(公告)日：2024-10-24
申请号：US18751439
申请日：2024-06-24
IPC分类号： A61K31/4439 , A61K9/00 , A61K45/06 , C07D417/12
CPC分类号： A61K31/4439 , A61K9/0014 , A61K45/06 , C07D417/12
摘要： The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.
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公开(公告)号：US20220306647A1
公开(公告)日：2022-09-29
申请号：US17607605
申请日：2020-04-29
IPC分类号： C07D498/04 , C07D487/04 , C07D471/04 , C07D471/14
摘要： The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
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![NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)](/abs-image/US/2022/01/13/US20220009931A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20220009931A1
公开(公告)日：2022-01-13
申请号：US17290541
申请日：2019-11-01
发明人： Alastair DONALD , Andreas URBAN , Susanne BONSMANN
IPC分类号： C07D487/04
摘要： The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
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公开(公告)号：US20200093814A1
公开(公告)日：2020-03-26
申请号：US16471677
申请日：2017-12-21
发明人： Irith WIEGAND , Cuong VUONG , Daniela M. RAUSCH
IPC分类号： A61K31/454 , A61K31/427 , A61K45/06 , A61K31/424 , A61K31/431 , A61K31/43 , A61P31/04
摘要： This invention relates to β-lactam compounds in combination with further drugs, e.g. β-lactamase inhibitors (BLIs), for use in the treatment and prophylaxis of infections caused by resistant bacteria.
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公开(公告)号：US10086046B2
公开(公告)日：2018-10-02
申请号：US15439845
申请日：2017-02-22
发明人： Daniela Paulsen , Nina Brunner , Dorothy Bray
摘要： The present invention relates to an agent for the treatment and/or prophylaxis of an autoimmune disease, an agent for the formation of regulatory T cells (TReg) in an organism and various methods in which the agents according to the invention are used.
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公开(公告)号：US20170362186A1
公开(公告)日：2017-12-21
申请号：US15640661
申请日：2017-07-03
IPC分类号： C07D239/84 , C07C309/30 , C07C309/29
CPC分类号： C07D239/84 , C07C309/29 , C07C309/30
摘要： The invention relates to besylate and tosylate salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl} acetic acid and solvates thereof, to the use thereof in a method of treating and/or preventing virus infections, and to the use thereof to produce drugs for use in treating and/or preventing diseases, in particular use as antiviral agents, in particular against cytomegaloviruses.
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公开(公告)号：US20170320918A1
公开(公告)日：2017-11-09
申请号：US15655825
申请日：2017-07-20
发明人： Olaf WEBER , Sonja Maria TENNAGELS , Angela SIEGLING , Tobias SCHLAPP , Andrew Allan MERCER , Stephen Bruce FLEMING , Hans-Dieter VOLK
IPC分类号： C07K14/005 , C12N15/86 , C07K14/065 , C12N7/00 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
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公开(公告)号：US09249148B2
公开(公告)日：2016-02-02
申请号：US14422191
申请日：2013-08-16
发明人： Steffen Wildum , Burkhard Klenke , Astrid Wendt
IPC分类号： C07D403/02 , C07D487/04 , A61K31/4745 , C07D471/04 , C07D401/14 , C07D403/04
CPC分类号： C07D487/04 , A61K31/4745 , C07D401/14 , C07D403/04 , C07D471/04
摘要： The present invention relates to new tri(hetero)aryl pyrazoles, methods for their preparation, their use for treating and/or preventing diseases as well as their use in the preparation of drugs for treating and/or preventing diseases, in particular retroviral diseases in humans and/or animals.
摘要翻译： 本发明涉及新的三（杂）芳基吡唑，其制备方法，其用于治疗和/或预防疾病的用途及其在制备用于治疗和/或预防疾病的药物中的用途，特别是用于治疗和/ 人类和/或动物。
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9.发明授权Recombinant proteins of Parapoxvirus ovis and pharmaceutical compositions therefrom 有权Parapoxvirus ovis的重组蛋白及其药物组合物公开(公告)号：US08852577B2
公开(公告)日：2014-10-07
申请号：US13717640
申请日：2012-12-17
发明人： Olaf Weber , Sonja Maria Tennagels , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , C07K14/065 , C12N15/86 , C07K14/005 , A61K39/00 , A61K48/00 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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10.发明申请RECOMBINANT PROTEINS OF PARAPOXVIRUS OVIS AND PHARMACEUTICAL COMPOSITIONS THEREFROM 有权PAR US ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM公开(公告)号：US20130108704A1
公开(公告)日：2013-05-02
申请号：US13717640
申请日：2012-12-17
发明人： Olaf WEBER , Sonja Maria FRIEDERICHS , Angela SIEGLING , Tobias SCHLAPP , Andrew Allan MERCER , Stephen Bruce FLEMING , Hans-Dieter VOLK
IPC分类号： C07K14/065
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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