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公开(公告)号：US20100273270A1
公开(公告)日：2010-10-28
申请号：US12769372
申请日：2010-04-28
IPC分类号： G01N27/00
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and at least one electrode. The second container has a second sample supply inlet for supplying the sample to the second container and a reagent holding part for holding a reagent for the optical measurement.
摘要翻译： 本发明的测量装置包括：第一容器和用于保持样品的第二容器; 以及用于进行光学测量的光学测量部件。 第一容器具有第一样品供应入口，用于将含有分析物的样品供应到第一容器和至少一个电极。 第二容器具有用于将样品供应到第二容器的第二样品供给入口和用于保持用于光学测量的试剂的试剂保持部。
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公开(公告)号：US20090170210A1
公开(公告)日：2009-07-02
申请号：US11995164
申请日：2006-10-24
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and at least one electrode. The second container has a second sample supply inlet for supplying the sample to the second container and a reagent holding part for holding a reagent for the optical measurement.
摘要翻译： 本发明的测量装置包括：第一容器和用于保持样品的第二容器; 以及用于进行光学测量的光学测量部件。 第一容器具有用于将含有分析物的样品供应到第一容器和至少一个电极的第一样品供应入口。 第二容器具有用于将样品供应到第二容器的第二样品供给入口和用于保持用于光学测量的试剂的试剂保持部。
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3.发明授权Method of judging homogenization/reaction completion and method of measuring solution concentration using the same 失效判断均质/反应完成的方法及使用该方法测定溶液浓度的方法公开(公告)号：US07476544B2
公开(公告)日：2009-01-13
申请号：US10507313
申请日：2003-03-12
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
CPC分类号： G01N21/272 , B01F5/0206 , G01N21/51 , G01N21/532 , G01N21/59 , G01N21/82 , G01N2021/0325 , G01N2021/513 , G01N2021/755 , G01N2021/7783 , G01N2201/1222
摘要： It is intended to provide a method for determining homogenization and/or reaction completion, capable of making the measurement time necessary and sufficient and enhancing the measurement speed, and a method for measuring solution concentration using the same. According to the method for determining homogenization and/or reaction completion and the method for measuring solution concentration using the same, homogenization and reaction completion are determined based on the optical property of the liquid mixture of a test liquid and a reagent liquid.
摘要翻译： 旨在提供一种能够确定均匀化和/或反应完成的方法，其能够使测量时间需要和充分并且提高测量速度，以及使用该方法测量溶液浓度的方法。 根据用于确定均质化和/或反应完成的方法以及使用其测定溶液浓度的方法，基于测试液体和试剂液体的液体混合物的光学性质来确定均化和反应完成。
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4.再颁专利公开(公告)号：USRE40209E1
公开(公告)日：2008-04-01
申请号：US09688077
申请日：2000-10-13
IPC分类号： C12M1/34
CPC分类号： C12M41/46 , G01N33/48728
摘要： A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct measurements accurately and efficiently as well as can improve convenience of arranging measurement results. According to the configuration of the cell potential measurement apparatus of this invention, it includes an integrated cell holding instrument, which includes a planar electrode provided with a plurality of microelectrodes arranged in a matrix form on the surface of a substrate, a cell holding part for placing cells thereon, drawer patterns from the microelectrodes, and electric contact points for outside connections; an optical observation means for optical observations of cells; a stimulation signal supply means to be connected to the cell holding instrument for providing electric stimulation to the cells; and a signal processing means to be connected to the cell holding instrument for processing an output signal arising from electric physiological activities of the cells. It is preferable that a cell culturing means is also provided for maintaining a culture atmosphere of the cells placed on the integrated cell holding instrument.
摘要翻译： 提供一种电池电位测量装置，其使用能够进行多点同时测量由电池活动引起的电位变化的平面电极，其可以精确且有效地进行测量，并且可以提高排列测量结果的便利性。 根据本发明的电池电位测量装置的结构，它包括一个集成的电池保持仪器，它包括一个平面电极，该平面电极设置有以矩阵形式布置在基片表面上的多个微电极， 在其上放置电池，来自微电极的抽屉图案和用于外部连接的电接触点; 用于细胞光学观察的光学观察装置; 刺激信号提供装置，连接到用于向细胞提供电刺激的细胞保持仪器; 以及信号处理装置，其连接到用于处理由电池的电生理活动引起的输出信号的电池保持装置。 还优选还设置有用于维持放置在集成电池保持器具上的电池的培养气氛的细胞培养装置。
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5.发明授权Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit 失效免疫测定法/设备，生物成分可测量马桶，抗白蛋白单克隆抗体，产生相同的细胞株和白蛋白检测试剂盒公开(公告)号：US07241578B2
公开(公告)日：2007-07-10
申请号：US10441192
申请日：2003-05-20
IPC分类号： G01K33/53 , G01K33/536 , G01K33/557 , G01K33/577 , C07K16/18 , C12N5/20 , C12P21/08
CPC分类号： A61B5/415 , A61B5/20 , A61B10/0038 , A61B10/007 , C07K16/18 , G01N33/577 , G01N33/68
摘要： The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monoclonal antibody capable of specifically binding to the subject substance; and (b) measuring an optical property of the mixed solution. The first monoclonal antibody is capable of binding to a first epitope of the subject substance, and the second monoclonal antibody is capable of binding to a second epitope of the subject substance different from the first epitope. Each of the first and second epitopes exists singly in the subject substance.
摘要翻译： 本发明的免疫测定方法测定样品中目标物质的含量。 该方法包括以下步骤：（a）通过混合样品和包含第一单克隆抗体和能够特异性结合本发明物质的第二单克隆抗体的抗体溶液来制备混合溶液; 和（b）测量混合溶液的光学性质。 第一单克隆抗体能够结合受试物质的第一表位，第二单克隆抗体能够结合不同于第一表位的受试物质的第二表位。 第一和第二表位中的每一个单独存在于主题物质中。
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公开(公告)号：US07226777B2
公开(公告)日：2007-06-05
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译： 根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。 样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。 水平。
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公开(公告)号：US07056682B2
公开(公告)日：2006-06-06
申请号：US10474755
申请日：2002-12-27
申请人： Akihito Kamei , Noriko Kenjo , Tatsuro Kawamura , Mahito Hirai
发明人： Akihito Kamei , Noriko Kenjo , Tatsuro Kawamura , Mahito Hirai
IPC分类号： G01N33/53
CPC分类号： G01N33/5375 , G01N33/536 , G01N33/539 , G01N33/542
摘要： In step St1 shown in FIG. 1, a reaction system including a sample for which the content of a subject substance is to be measured, a specific-binding substance specifically binding to the subject substance, and phthalic acid or phthalate salt is constructed. The pH of the reaction system is set at less than 7. When the subject substance is an antigen, the specific-binding substance is an antibody. In reverse, when the subject substance is an antibody, the specific-binding substance is an antigen. In step St2 in FIG. 1, an optical property of the reaction system is measured. When agglutinate complexes are produced in the step St1, the reaction system becomes turbid, causing a change in scattered light intensity, transmitted light amount and the like. Therefore, by measuring the scattered light intensity, the transmitted light amount or the like, the degree of turbidity of the reaction system can be estimated.
摘要翻译： 在图1所示的步骤St 1中， 如图1所示，构成了包含被测定物质含量的样品，特异性结合物质的特异性结合物和邻苯二甲酸或邻苯二甲酸盐的反应体系。 反应体系的pH设定为小于7.当目标物质为抗原时，特异性结合物质为抗体。 相反，当目标物质是抗体时，特异性结合物质是抗原。 在图3的步骤St2中 如图1所示，测定反应体系的光学特性。 当在步骤St 1中产生凝集络合物时，反应体系变得混浊，导致散射光强度，透射光量等的变化。 因此，通过测量散射光强度，透射光量等，可以估计反应体系的浊度。
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公开(公告)号：US20050215868A1
公开(公告)日：2005-09-29
申请号：US11086419
申请日：2005-03-23
申请人： Noriko Kenjou , Tatsurou Kawamura , Akihito Kamei
发明人： Noriko Kenjou , Tatsurou Kawamura , Akihito Kamei
CPC分类号： A61B5/021 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B2560/0242 , A61B2560/0261
摘要： The vital sign processing apparatus in the present invention includes: a vital sign measurement unit that measures a vital sign of a subject; a designated condition notification unit that notifies the subject of a designated condition to be followed during measurement of the vital sign using the vital sign measurement unit; a measurement condition recognition unit that recognizes, without input from the subject, a measurement condition at a time the vital sign is measured by the subject using the vital sign measurement unit; a condition comparison unit that compares the designated condition notified by the designated condition notification unit, with the measurement condition recognized by the measurement condition recognition unit; and a presentation unit that presents a comparison result from the condition comparison unit.
摘要翻译： 本发明的生命体征处理装置包括：生命体测量单元，其测量被检体的生命体征; 指定条件通知单元，其使用所述生命体测量单元向所述对象通知所述生命体征的测量期间要遵循的指定条件; 测量条件识别单元，在不使用所述对象的输入的情况下，识别由所述对象使用所述生命体测量单元测量的生命体征时的测量条件; 条件比较单元，将由指定条件通知单元通知的指定条件与由测量条件识别单元识别的测量条件进行比较; 以及呈现单元，其呈现来自条件比较单元的比较结果。
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9.发明申请Method of judging homogenization/reaction completion and method of measuring solution concentration using the same 失效判断均质/反应完成的方法及使用该方法测定溶液浓度的方法公开(公告)号：US20050101028A1
公开(公告)日：2005-05-12
申请号：US10507313
申请日：2003-03-12
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
IPC分类号： B01F5/02 , G01N21/03 , G01N21/27 , G01N21/51 , G01N21/53 , G01N21/59 , G01N21/75 , G01N21/77 , G01N21/82 , G01N21/00
CPC分类号： G01N21/272 , B01F5/0206 , G01N21/51 , G01N21/532 , G01N21/59 , G01N21/82 , G01N2021/0325 , G01N2021/513 , G01N2021/755 , G01N2021/7783 , G01N2201/1222
摘要： It is intended to provide a method for determining homogenization and/or reaction completion, capable of making the measurement time necessary and sufficient and enhancing the measurement speed, and a method for measuring solution concentration using the same. According to the method for determining homogenization and/or reaction completion and the method for measuring solution concentration using the same, homogenization and reaction completion are determined based on the optical property of the liquid mixture of a test liquid and a reagent liquid.
摘要翻译： 旨在提供一种能够确定均匀化和/或反应完成的方法，其能够使测量时间需要和充分并且提高测量速度，以及使用该方法测量溶液浓度的方法。 根据用于确定均质化和/或反应完成的方法以及使用其测定溶液浓度的方法，基于测试液体和试剂液体的液体混合物的光学性质来确定均化和反应完成。
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公开(公告)号：US06288527B1
公开(公告)日：2001-09-11
申请号：US08661314
申请日：1996-06-13
IPC分类号： G01N2700
CPC分类号： G01N33/48728 , G01N27/305 , Y10S436/806
摘要： A two-dimensional sensor is described including a substrate having a Si layer, a SiO2 layer and a Si3N4 layer. On the surface of the Si back side, a thin film is formed by vapor deposition for making an effect electrode. On the surface of the Si3N4 front side, a fence is attached for containing a sample cell, culture medium and a reference electrode. This sensor is placed in an incubator and a bias voltage is applied between the effect and reference electrodes. When a high frequency modulated laser beam irradiates a spot on the back side of the sensor substrate, a signal of AC photocurrent is obtained from the effect electrode. This signal corresponds to a potential alteration due to the cell activity substantially at the spot. The signal is processed in a computer. Therefore, the beam spot size and location, corresponding to the size and the location of the measurement electrode, can be adjusted easily by focusing or moving the laser beam.
摘要翻译： 描述了包括具有Si层，SiO 2层和Si 3 N 4层的衬底的二维传感器。 在Si背面的表面上，通过气相沉积形成用于制作效应电极的薄膜。 在Si3N4正面的表面上，附着有用于容纳样品池，培养基和参比电极的栅栏。 将该传感器放置在培养箱中，并且在效果和参考电极之间施加偏置电压。 当高频调制激光束照射传感器基板的背面的点时，从效应电极获得AC光电流的信号。 该信号对应于由于细胞活性基本上在斑点的潜在的改变。 信号在计算机中处理。 因此，可以通过聚焦或移动激光束来容易地调整对应于测量电极的尺寸和位置的束斑尺寸和位置。
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