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公开(公告)号：US20070072231A1
公开(公告)日：2007-03-29
申请号：US11603619
申请日：2006-11-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/99 , C07K14/525
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US20120156722A1
公开(公告)日：2012-06-21
申请号：US13401978
申请日：2012-02-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US08124733B2
公开(公告)日：2012-02-28
申请号：US12888572
申请日：2010-09-23
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07825220B2
公开(公告)日：2010-11-02
申请号：US12626290
申请日：2009-11-25
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US20100112591A1
公开(公告)日：2010-05-06
申请号：US12626290
申请日：2009-11-25
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07153935B2
公开(公告)日：2006-12-26
申请号：US10045815
申请日：2001-10-26
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
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公开(公告)号：US20110008913A1
公开(公告)日：2011-01-13
申请号：US12888572
申请日：2010-09-23
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
摘要翻译： 从人睾丸cDNA文库中成功分离了编码参与细胞增殖控制的新蛋白质（人类Gros1-L和S）的全长cDNA。 还分离了编码人Gros1（小鼠Gros1-L和S）的小鼠同系物的全长cDNA。 外源性表达Gros1-L的细胞的集落形成活性显着降低，而表达Gros1反义RNA的细胞的集落形成活性显着增加。
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公开(公告)号：US07642070B2
公开(公告)日：2010-01-05
申请号：US11603619
申请日：2006-11-22
申请人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
发明人： Renu Wadhwa , Takashi Sugihara , Akiko Ohide
IPC分类号： C12N15/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells exogenously expressing Gros1-L was significantly reduced, while that of cells expressing Gros1 antisense RNA was significantly increased.
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