公开(公告)号：US08410059B2

公开(公告)日：2013-04-02

申请号：US13178737

申请日：2011-07-08

申请人： Nobutaka Fujii ,  Hirokazu Tamamura ,  Akira Hori

发明人： Nobutaka Fujii ,  Hirokazu Tamamura ,  Akira Hori

IPC分类号： A61K38/10 ,  A61K38/00 ,  C07K7/08 ,  C07K7/00

CPC分类号： C07K7/08 ,  A61K38/00

摘要： Therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt are described. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.

摘要翻译： 描述了含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的用于癌症和慢性类风湿性关节炎的治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。

公开(公告)号：US20110269686A1

公开(公告)日：2011-11-03

申请号：US13178737

申请日：2011-07-08

申请人： Nobutaka FUJII ,  Hirokazu TAMAMURA ,  Akira HORI

发明人： Nobutaka FUJII ,  Hirokazu TAMAMURA ,  Akira HORI

IPC分类号： A61K38/10 ,  A61P35/04 ,  A61P29/00 ,  A61P35/02 ,  C07K7/08 ,  A61P35/00

CPC分类号： C07K7/08 ,  A61K38/00

摘要： The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.

摘要翻译： 本发明提供含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的癌症和慢性类风湿性关节炎的预防和/或治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。

公开(公告)号：US20100210545A1

公开(公告)日：2010-08-19

申请号：US12738287

申请日：2008-10-15

申请人： Shinsuke Araki ,  Akira Hori ,  Yuusuke Nakayama

发明人： Shinsuke Araki ,  Akira Hori ,  Yuusuke Nakayama

IPC分类号： A61K38/16 ,  C12Q1/02

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/178

摘要： The present invention provides identification of TRAIL signal activator sensitivity markers in cancer cells, and a method of diagnosing the sensitivity to TRAIL signal activator in a cancer patient using the markers. Tailor-made medical service of administering a TRAIL signal activator to a TRAIL signal activator sensitive cancer patient is provided.The present invention provides a preventive or remedy agent for cancer for a TRAIL signal activator sensitive patient, the agent comprising a TRAIL signal activator, wherein the patient is screened by using the fluctuation in the expression or activity of TRAIL signal activator sensitivity markers in a sample collected from a test subject, as an index. As the TRAIL signal activator sensitivity markers, AIM1, STK17B, LOC93349, CASP8 and the like may be mentioned.

摘要翻译： 本发明提供癌细胞中TRAIL信号激活剂灵敏度标志物的鉴定，以及使用标记物诊断癌症患者对TRAIL信号激活剂敏感性的方法。 提供了向TRAIL信号激活剂敏感性癌症患者施用TRAIL信号激活剂的定制医疗服务。 本发明提供了一种用于TRAIL信号激活剂敏感患者的癌症的预防或补救剂，该试剂包含TRAIL信号激活剂，其中通过使用样品中TRAIL信号激活剂敏感性标志物的表达或活性的波动来筛选患者 从测试科目收集，作为指标。 作为TRAIL信号激活剂敏感性标记，可以提及AIM1，STK17B，LOC93349，CASP8等。

公开(公告)号：US07423007B2

公开(公告)日：2008-09-09

申请号：US10525838

申请日：2003-08-26

申请人： Nobutaka Fujii ,  Hirokazu Tamamura ,  Akira Hori

发明人： Nobutaka Fujii ,  Hirokazu Tamamura ,  Akira Hori

IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K38/10 ,  C07K5/00 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00

摘要： The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.

摘要翻译： 本发明提供含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的癌症和慢性类风湿性关节炎的预防和/或治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。

公开(公告)号：US20070204822A1

公开(公告)日：2007-09-06

申请号：US11712553

申请日：2007-03-01

申请人： Akira Hori ,  Eiji Isobe ,  Yoshihito Moriya ,  Takashi Inoue ,  Koichi Shimizu

发明人： Akira Hori ,  Eiji Isobe ,  Yoshihito Moriya ,  Takashi Inoue ,  Koichi Shimizu

IPC分类号： F01L1/34

CPC分类号： F01L1/3442

摘要： A valve timing controller is provided with a first rotary element that rotates in response to the movement of a crankshaft, a second rotary element that rotates in response to the movement of a camshaft. A link mechanism changes a relative rotation phase between the first and second rotary elements. The first and second rotary elements include introduction passages that introduce a lubricating fluid in the first rotary element. In the link mechanism, shafts are fitted in the links. The links relatively rotate with respect to the shaft, and include conveying passages to communicate with the introduction passages and convey the lubricating fluid from the introduction passages to the circumference of the shaft.

摘要翻译： 气门正时控制器设置有响应于曲轴的运动而旋转的第一旋转元件，响应于凸轮轴的运动而旋转的第二旋转元件。 连杆机构改变第一和第二旋转元件之间的相对旋转相位。 第一和第二旋转元件包括在第一旋转元件中引入润滑流体的引入通道。 在连杆机构中，轴连接在轴上。 连杆相对于轴相对旋转，并且包括与引入通道连通的输送通道，并将润滑流体从引入通道输送到轴的圆周。

公开(公告)号：US20070012270A1

公开(公告)日：2007-01-18

申请号：US11482704

申请日：2006-07-10

申请人： Akira Hori ,  Akihiko Takenaka ,  Shuji Mizutani

发明人： Akira Hori ,  Akihiko Takenaka ,  Shuji Mizutani

IPC分类号： F01L1/34

CPC分类号： F01L1/352 ,  F01L1/344 ,  F01L2001/34436 ,  F01L2820/032

摘要： A valve timing adjusting device includes: a first rotary body which rotates in synchronization with one of a crankshaft and a camshaft and into which lubricating fluid is supplied; a second rotary body which rotates in synchronization with the other; a torque producing unit for producing control torque; and a phase change unit including a planetary gear mechanism in which a planetary gear is engaged with a sun gear in such a way as to be able to perform a planetary motion. The phase change unit changes a relative rotational phase between the first rotary body and the second rotary body by utilizing the control torque transmitted from the torque producing unit to the planetary gear mechanism and has a space at an interface where the first rotary body is brought into sliding contact with the planetary gear.

公开(公告)号：US06439184B1

公开(公告)日：2002-08-27

申请号：US10046816

申请日：2002-01-17

申请人： Akihiko Takenaka ,  Masashi Hayashi ,  Akira Hori

发明人： Akihiko Takenaka ,  Masashi Hayashi ,  Akira Hori

IPC分类号： F01L134

CPC分类号： F01L1/34 ,  F01L2001/34426 ,  F01L2001/34469 ,  F01L2001/34483 ,  F01L2800/03

摘要： An effective range of urging force of an assist spring is between a maximum retarded phase and a predetermined phase of a camshaft, a vane rotor and vanes. The predetermined phase is equal to an intermediate locking phase of the camshaft, the rotor and the vanes+10 degree CA. Even when oil pressure supplied to each advancing chamber is reduced at the time of engine stop, the camshaft, the rotor and the vanes can be advanced to or beyond the intermediate phase by the spring. Furthermore, at the time of engine start, the rotor and the vanes are positioned near the intermediate phase, so that reaction force of the spring is very small, allowing easy movement of the rotor with drive torque of the camshaft toward a retard side. Thus, the rotor can be locked at the intermediate phase by a lock pin.

摘要翻译： 辅助弹簧的有效作用力范围在凸轮轴，叶片转子和叶片的最大延迟相位和预定相位之间。 预定相位等于凸轮轴，转子和叶片+ 10度CA的中间锁定相位。 即使在发动机停止时，供给到每个行进室的油压降低，凸轮轴，转子和叶片可以通过弹簧进入或超过中间相。 此外，在发动机起动时，转子和叶片位于中间相附近，使得弹簧的反作用力非常小，允许转子与凸轮轴的驱动扭矩容易地向延迟侧运动。 因此，转子可以通过锁定销锁定在中间相位。

公开(公告)号：US6135078A

公开(公告)日：2000-10-24

申请号：US190221

申请日：1998-11-13

申请人： Toshinori Doi ,  Osamu Sato ,  Jouji Yamaguchi ,  Akira Hori

发明人： Toshinori Doi ,  Osamu Sato ,  Jouji Yamaguchi ,  Akira Hori

IPC分类号： F01L1/344 ,  F01L13/00 ,  F01L1/34

CPC分类号： F01L1/344 ,  F01L13/0042 ,  F01L2201/00 ,  F02D2041/001

摘要： A cam has a profile variable from a high lift curve to a low lift curve in an axial direction. A driving mechanism shifts a cam shaft in the axial direction. A phase adjusting mechanism adjusts the rotational phase of the cam shaft relative to a driving shaft of the internal combustion engine. Angle detecting teeth are shift detecting teeth are alternately arranged on a same cylindrical surface of the cam shaft. Each shift detecting tooth incline at a predetermined angle with respect to an axis of the cam shaft so as to provide angularly advanced and retarded portions in a rotational direction of the cam shaft. A pickup generates sensing signals responsive to the angle detecting teeth and the shift detecting teeth. The sensor faces the angularly advanced portion of the shift detecting tooth when the low lift curve of the cam is selected and faces the angularly retarded portion of the shift detecting tooth when the high lift curve of the cam is selected.

摘要翻译： 凸轮具有从高升力曲线到轴向方向的低升力曲线的轮廓变量。 驱动机构沿轴向移动凸轮轴。 相位调整机构调节凸轮轴相对于内燃机的驱动轴的转动相位。 角度检测齿是移动检测齿交替地布置在凸轮轴的同一圆柱形表面上。 每个换档检测齿相对于凸轮轴的轴线以预定的角度倾斜，以便在凸轮轴的旋转方向上提供角度提前和延迟的部分。 拾取器产生响应于角度检测齿和换档检测齿的感测信号。 当选择凸轮的高升力曲线时，当选择凸轮的低升力曲线并且面对换档检测齿的角度延迟部分时，传感器面向换档检测齿的角度前进部分。

公开(公告)号：US4854889A

公开(公告)日：1989-08-08

申请号：US197853

申请日：1988-05-24

申请人： Hiroo Ohtsuka ,  Osamu Hara ,  Akira Hori ,  Minoru Noda

发明人： Hiroo Ohtsuka ,  Osamu Hara ,  Akira Hori ,  Minoru Noda

IPC分类号： H01R4/24

CPC分类号： H01R4/2433

摘要： An electrical connector includes contacts to be connected to lead wires and a housing having apertures for receiving the contacts. The lead wires are connected to the contacts when the contacts are forced into the apertures of the housing. Each of the contacts comprises at one end a contact element to be in contact with an external terminal and at the other end a connection portion formed with a lead aperture through which a lead wire passes and with a slit continuous with the lead aperture. Edges of the slit pierce into an insulating coating of the lead wire and connect with a core of the lead wire under pressure. The housing is formed with through-apertures through each of which the contact element of each of the contacts extends and with receiving apertures each for receiving the lead wire under a condition that the edges of the slit of the connection portion of the contact pierce into the insulating coating of the lead wire and connect with the core of the lead wire under pressure and a remaining insulating coating is doubled. A doubled end of the lead wire received in each of the receiving apertures is positioned by a shoulder formed by a boundary wall between the receiving aperture and the through-aperture.

摘要翻译： 电连接器包括要连接到引线的触点和具有用于接收触点的孔的壳体。 当触头被迫进入外壳的孔口时，引线连接到触点。 每个触点的一端包括与外部端子接触的接触元件，而另一端形成有引线孔的连接部分，引线通过该连接部分，并且与引线孔连通。 狭缝的边缘刺入导线的绝缘涂层，并在压力下与引线的芯连接。 壳体形成有通孔，通孔中的每一个的接触元件都延伸有接触孔，并且具有接收孔，每个接收孔用于在接触件的连接部分的狭缝的边缘刺入其中的条件下接收引线 引线的绝缘涂层和压力下的引线芯连接，剩余的绝缘涂层加倍。 在每个接收孔中容纳的引线的双端位于由接收孔和通孔之间的边界壁形成的肩部上。

公开(公告)号：US07278386B2

公开(公告)日：2007-10-09

申请号：US11482704

申请日：2006-07-10

申请人： Akira Hori ,  Akihiko Takenaka ,  Shuji Mizutani

发明人： Akira Hori ,  Akihiko Takenaka ,  Shuji Mizutani

IPC分类号： F01L1/34

CPC分类号： F01L1/352 ,  F01L1/344 ,  F01L2001/34436 ,  F01L2820/032

摘要： A valve timing adjusting device includes: a first rotary body which rotates in synchronization with one of a crankshaft and a camshaft and into which lubricating fluid is supplied; a second rotary body which rotates in synchronization with the other; a torque producing unit for producing control torque; and a phase change unit including a planetary gear mechanism in which a planetary gear is engaged with a sun gear in such a way as to be able to perform a planetary motion. The phase change unit changes a relative rotational phase between the first rotary body and the second rotary body by utilizing the control torque transmitted from the torque producing unit to the planetary gear mechanism and has a space at an interface where the first rotary body is brought into sliding contact with the planetary gear.

摘要翻译： 一种气门正时调节装置，包括：第一旋转体，其与曲轴和凸轮轴中的一个同步旋转并供应润滑液; 与另一个同步旋转的第二旋转体; 用于产生控制扭矩的扭矩产生单元; 以及相位改变单元，其包括行星齿轮机构，其中行星齿轮以能够执行行星运动的方式与太阳齿轮接合。 相变单元通过利用从转矩产生单元传递到行星齿轮机构的控制扭矩，改变第一旋转体和第二旋转体之间的相对旋转相位，并且在第一旋转体进入的界面处具有空间 与行星齿轮滑动接触。