公开(公告)号：US20060178320A1

公开(公告)日：2006-08-10

申请号：US11297152

申请日：2005-12-07

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  A61K31/675 ,  A61K31/522 ,  A61K31/513 ,  A61K31/255 ,  A61K31/519

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

摘要翻译： 通过抑制底物的转化以产生倒数第二或最终产物，特别是通过抑制途径中一种或多种酶的活性，通过抑制代谢途径中的一种或多种酶来鉴定和治疗致病微生物感染的方法， 以及通过抑制这种酶抑制致病微生物感染的化合物和药物组合物。

公开(公告)号：US20060130832A1

公开(公告)日：2006-06-22

申请号：US11021743

申请日：2004-12-22

申请人： Alan Schechter ,  Adam Schechter

发明人： Alan Schechter ,  Adam Schechter

IPC分类号： A61M15/00

CPC分类号： A61M15/009 ,  A61M15/008 ,  A61M2016/0021 ,  A61M2205/3389 ,  A61M2205/502

摘要： Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in the vessel. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer; methods for comparing the amount of contents actually released from the vessel compared to a theoretical constant; and methods for time logging (alone or in conjunction with the logging of other data) the actuation of the dispensing valve for comparison to a prescribed method. Devices for incrementally dispensing pressurized contents from such containers are also described. Such devices further comprise a metering value for dispensing pressurized contents from the vessel. In preferred embodiments, each actuation of the metering valve results in release of a pre-determined quantity of the vessel contents. For example, in embodiments wherein the pressurized contents comprise a therapeutic composition, the instant devices include improved Metered Dose Inhalers (MDIs) for delivery of predetermined doses of a therapeutic composition to a patient, wherein the MDIs provide for sensing of the amount, for example, of the therapeutic composition remaining in the vessel after each actuation of the metering valve.

摘要翻译： 描述了用于增量分配加压内容物的容器。 容器包括适于容纳加压内容物的容器，与容器成一体的端口，容器中容纳的加压内容物可以通过该容器从容器中释放，优选地以大致相等的量递增，以及设置在容器中的测量装置。 测量装置感测容器中的环境条件，并且直接或与其他部件表示例如容器中剩余的加压内容物的量并将其显示给观察者; 用于比较实际从船舶释放的内容物量与理论常数相比较的方法; 以及用于与规定的方法进行比较的时间记录（单独地或与记录其他数据一起）分配阀的致动的方法。 还描述了用于从这种容器递增地分配加压内容物的装置。 这种装置还包括用于从容器分配加压内容物的计量值。 在优选实施例中，计量阀的每次致动导致预定数量的容器内容物的释放。 例如，在其中加压内容物包含治疗组合物的实施方案中，本发明装置包括用于将预定剂量的治疗组合物递送给患者的改进的计量剂量吸入器（MDI），其中MDI用于感测量，例如 的每次致动计量阀后残留在容器中的治疗组合物。

公开(公告)号：US20060177385A1

公开(公告)日：2006-08-10

申请号：US11397020

申请日：2006-04-02

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： A61K31/7076 ,  A61K8/49

CPC分类号： C12Q1/18 ,  G01N2333/91102 ,  G01N2333/9125

摘要： A method and pharmaceutical composition for inhibiting infections of S. mutans by the addition of said composition to toothpaste or mouthwash, by inhibiting the production of ADP-glucose, particularly by inhibiting the activity of ADP-glucose pyrophosphorylase or glycogen synthase.

摘要翻译： 通过抑制ADP-葡萄糖的产生，特别是通过抑制ADP-葡萄糖焦磷酸化酶或糖原合成酶的活性，通过将所述组合物加入到牙膏或漱口剂中来抑制变形链球菌感染的方法和药物组合物。

公开(公告)号：US20060252112A1

公开(公告)日：2006-11-09

申请号：US11297146

申请日：2005-12-07

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： C12Q1/18 ,  A61K31/185 ,  A61K31/7076

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

摘要翻译： 通过抑制底物的转化以产生倒数第二或最终产物，特别是通过抑制途径中一种或多种酶的活性，通过抑制代谢途径中的一种或多种酶来鉴定和治疗致病微生物感染的方法， 以及通过抑制这种酶抑制致病微生物感染的化合物和药物组合物。

公开(公告)号：US20060182815A1

公开(公告)日：2006-08-17

申请号：US10563682

申请日：2004-07-09

申请人： Mark Gladwin ,  Richard Cannon III ,  Alan Schechter

发明人： Mark Gladwin ,  Richard Cannon III ,  Alan Schechter

IPC分类号： A61K33/00

CPC分类号： A61K45/06 ,  A61K31/519 ,  A61K33/00 ,  Y02A50/411

摘要： It has been surprisingly discovered that administration of pharmaceutically-acceptable salts of nitrite is useful in the regulation of the cardiovascular system. It has also been surprisingly discovered that nitrite is reduced to nitric oxide in vivo, and that the nitric oxide produced thereby is an effective vasodilator. These effects surprisingly occur at nitrite doses that do not produce clinically significant methemoglobinemia. These discoveries now enable methods to prevent and treat conditions associated with the cardiovascular system, for example, high blood pressure, pulmonary hypertension, cerebral vasospasm and tissue ischemia-reperfusion injury. These discoveries also provide methods to increase blood flow to tissues, for example, to tissues in regions of low oxygen tension.

摘要翻译： 已经令人惊讶地发现，施用亚硝酸盐的药学上可接受的盐可用于调节心血管系统。 也惊奇地发现，亚硝酸盐在体内被还原成一氧化氮，并且由此产生的一氧化氮是有效的血管扩张剂。 这些效应令人惊讶地发生在不产生临床显着的高铁血红蛋白血症的亚硝酸盐剂量。 这些发现现在使得能够预防和治疗与心血管系统相关的病症的方法，例如高血压，肺动脉高压，脑血管痉挛和组织缺血 - 再灌注损伤。 这些发现还提供了增加血液流向组织的方法，例如提供低氧张力区域的组织。

公开(公告)号：US20060094075A1

公开(公告)日：2006-05-04

申请号：US11297250

申请日：2005-12-07

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： C12Q1/18 ,  A61K31/255 ,  A61K31/66

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

摘要翻译： 通过抑制底物的转化以产生倒数第二或最终产物，特别是通过抑制途径中一种或多种酶的活性，通过抑制代谢途径中的一种或多种酶来鉴定和治疗致病微生物感染的方法， 以及通过抑制这种酶抑制致病微生物感染的化合物和药物组合物。

公开(公告)号：US20060063224A1

公开(公告)日：2006-03-23

申请号：US11253147

申请日：2005-10-17

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： C12Q1/18

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway

公开(公告)号：US20060252113A1

公开(公告)日：2006-11-09

申请号：US11297243

申请日：2005-12-07

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： C12Q1/18 ,  A61K31/7076 ,  A61K31/185 ,  A61K31/195 ,  A61K31/66

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

摘要翻译： 通过抑制底物的转化以产生倒数第二或最终产物，特别是通过抑制途径中一种或多种酶的活性，通过抑制代谢途径中的一种或多种酶来鉴定和治疗致病微生物感染的方法， 以及通过抑制这种酶抑制致病微生物感染的化合物和药物组合物。

公开(公告)号：US20070154569A1

公开(公告)日：2007-07-05

申请号：US10563683

申请日：2004-07-09

申请人： Mark Gladwin ,  Alan Schechter ,  David Lefer ,  Rakesh Patel ,  Christian Hunter ,  Gordon Power ,  Daniel Kim-Shapiro ,  Ryszard Pluta ,  Edward Oldfield ,  Richard Cannon

发明人： Mark Gladwin ,  Alan Schechter ,  David Lefer ,  Rakesh Patel ,  Christian Hunter ,  Gordon Power ,  Daniel Kim-Shapiro ,  Ryszard Pluta ,  Edward Oldfield ,  Richard Cannon

IPC分类号： A61K33/00 ,  A61P9/00 ,  A01N59/00 ,  A61P11/00

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血 - 再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US20060178322A1

公开(公告)日：2006-08-10

申请号：US11297515

申请日：2005-12-07

申请人： Alan Schechter

发明人： Alan Schechter

IPC分类号： A61K31/7072 ,  A61K31/7076 ,  A61K31/675 ,  A61K31/519 ,  A61K31/255 ,  A61K31/522

CPC分类号： C12Q1/18

摘要： A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

摘要翻译： 通过抑制底物的转化以产生倒数第二或最终产物，特别是通过抑制途径中一种或多种酶的活性，通过抑制代谢途径中的一种或多种酶来鉴定和治疗致病微生物感染的方法， 以及通过抑制这种酶抑制致病微生物感染的化合物和药物组合物。