公开(公告)号：US20090118369A1

公开(公告)日：2009-05-07

申请号：US10565135

申请日：2003-12-19

申请人： Doris Bell ,  Albrecht Weiss ,  Albert Strube ,  Bernd Fabry ,  Gerhard Jahreis ,  Anke Jaudszus

发明人： Doris Bell ,  Albrecht Weiss ,  Albert Strube ,  Bernd Fabry ,  Gerhard Jahreis ,  Anke Jaudszus

IPC分类号： A61K31/19 ,  A61P29/00 ,  A61P11/00

CPC分类号： A61K31/201

摘要： A composition and medicament comprising the cis-9, trans-11 isomer of conjugated linoleic acid for treating inflammatory diseases, including asthma, is provided. A method for inhibiting the proliferation of human or animal cells of the immune systems involved in an immune response including administering the cis-9, trans-11 isomer of conjugated linoleic acid to a patient is also provided. A nutritional, functional food, or dietary supplement including the cis-9, trans-11 isomer of conjugated linoleic acid is also provided.

摘要翻译： 提供了包含用于治疗炎症性疾病（包括哮喘）的共轭亚油酸的顺式-9反式-11异构体的组合物和药物。 还提供了抑制涉及免疫应答的免疫系统的人或动物细胞增殖的方法，包括向患者施用共轭亚油酸的顺式-9反式-11异构体。 还提供了营养功能食品或膳食补充剂，包括共轭亚油酸的顺式-9反式-11异构体。

公开(公告)号：US20050038266A1

公开(公告)日：2005-02-17

申请号：US10488651

申请日：2002-08-29

申请人： David Herault ,  Bernd Boutty ,  Lars Zander ,  Albert Strube

发明人： David Herault ,  Bernd Boutty ,  Lars Zander ,  Albert Strube

IPC分类号： C07D317/36 ,  C07D317/08 ,  C07C69/96

CPC分类号： C07D317/36

摘要： A process for making a purified glycerol carbonate involving: (a) providing a mixture of crude glycerol carbonate, wherein said mixture contains glycerol carbonate, glycerol and oligomeric glycerol carbonate; (b) providing a substantially water-free base component; (c) reacting the mixture with the base component to form a reaction mixture; and (d) filtering the reaction mixture to form the purified glycerol carbonate.

摘要翻译： 制备纯化的甘油碳酸酯的方法涉及：（a）提供粗甘油碳酸酯的混合物，其中所述混合物含有甘油碳酸酯，甘油和低聚甘油碳酸酯; （b）提供基本上无水的基础组分; （c）使混合物与基础组分反应以形成反应混合物; 和（d）过滤反应混合物以形成纯化的甘油碳酸酯。

公开(公告)号：US07084286B2

公开(公告)日：2006-08-01

申请号：US10489017

申请日：2002-08-28

申请人： Lars Zander ,  Albert Strube ,  Andreas Heidbreder ,  Alfred Westfechtel ,  Wolfgang Giede

发明人： Lars Zander ,  Albert Strube ,  Andreas Heidbreder ,  Alfred Westfechtel ,  Wolfgang Giede

IPC分类号： C07C51/347

CPC分类号： C11C3/14 ,  C07C67/333 ,  C07C69/587

摘要： Processes for preparing conjugated fatty acid products are described wherein (a) a composition which comprises a fatty acid ester having at least two unconjugated, carbon-carbon double bonds is provided; (b) the fatty acid ester is conjugated in the presence of a water-free base; (c) phosphoric acid is added to the conjugated fatty acid ester such that phosphate salts are precipitated; and (d) the precipitated phosphate salts are removed.

摘要翻译： 描述了制备共轭脂肪酸产物的方法，其中（a）包含具有至少两个未共轭碳碳双键的脂肪酸酯的组合物; （b）脂肪酸酯在无水碱的存在下共轭; （c）将磷酸加入到共轭脂肪酸酯中，使得磷酸盐沉淀; 和（d）去除沉淀的磷酸盐。

公开(公告)号：US20100311835A1

公开(公告)日：2010-12-09

申请号：US12701971

申请日：2010-02-08

申请人： Doris Bell ,  Albrecht Weiss ,  Albert Strube ,  Bernd Fabry ,  Gerhard Jahreis ,  Anke Jaudszus

发明人： Doris Bell ,  Albrecht Weiss ,  Albert Strube ,  Bernd Fabry ,  Gerhard Jahreis ,  Anke Jaudszus

IPC分类号： A61K31/201 ,  A61P11/06 ,  A61P11/00

CPC分类号： A61K31/201

摘要： A composition and medicament comprising the cis-9, trans-11 isomer of conjugated linoleic acid for treating inflammatory diseases, including asthma, is provided. A method for inhibiting the proliferation of human or animal cells of the immune systems involved in an immune response including administering the cis-9, trans-11 isomer of conjugated linoleic acid to a patient is also provided. A nutritional, functional food, or dietary supplement including the cis-9, trans-11 isomer of conjugated linoleic acid is also provided.

摘要翻译： 提供了包含用于治疗炎症性疾病（包括哮喘）的共轭亚油酸的顺式-9反式-11异构体的组合物和药物。 还提供了抑制涉及免疫应答的免疫系统的人或动物细胞增殖的方法，包括向患者施用共轭亚油酸的顺式-9反式-11异构体。 还提供了营养功能食品或膳食补充剂，包括共轭亚油酸的顺式-9反式-11异构体。

公开(公告)号：US07754484B2

公开(公告)日：2010-07-13

申请号：US11595538

申请日：2006-11-10

申请人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

发明人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

IPC分类号： C12N5/02

CPC分类号： C12N5/0037 ,  C12N2500/36 ,  C12N2500/72 ,  C12N2500/76 ,  C12N2500/82 ,  C12N2500/90

摘要： The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24 carbon atoms and 2 to 5 double bonds as the acid component and a lower C1-4 alcohol, preferably ethanol, or a sterol as ester component. In another aspect, the esters comprise a transesterification product of natural or synthetic oils or a mixture of such oils having greater than 50 mol-% of unsaturated, physiologically active fatty acids, based on the acyl group, and a lower C1-4 alcohol or a sterol. In a further aspect, the esters are used together with sterols, phospholipids and/or vegetable proteins or are liposomally encapsulated.

摘要翻译： 所公开的发明涉及使用不饱和生理活性脂肪酸的酯作为细胞培养的营养培养基，更特别地，作为胎牛血清的替代物。 一方面，酯包含大于50mol％的含有16-24个碳原子和2-5个双键的生理活性脂肪酸作为酸组分和一个低级C 1-4醇，优选乙醇或作为酯的固醇 零件。 在另一方面，酯包括天然或合成油的酯交换产物或具有大于50摩尔％的基于酰基的不饱和的生理活性脂肪酸的这种油的混合物，以及较低的C 1-4醇或 一种甾醇 在另一方面，酯与甾醇，磷脂和/或植物蛋白质一起使用或被脂质体包封。

公开(公告)号：US20080033191A1

公开(公告)日：2008-02-07

申请号：US11880928

申请日：2007-07-25

申请人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

发明人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

IPC分类号： C07C51/00

CPC分类号： C07C29/88 ,  A61K47/10 ,  C07C31/225

摘要： The invention describes a process for the production of glycerol of providing a vegetable oil or fat as starting material, obtaining crude glycerol from the vegetable oil or fat, and treating the crude glycerol with a reducing agent. The present invention also describes a process for the production of a medicament or pharmaceutical composition, the medicament or composition formed by combining glycerol and at least one pharmaceutically active ingredient. The present invention also describes a pharmaceutical composition or medicament composed of glycerol obtained by way of the invention and a pharmaceutically active ingredient, which compositions forms very little glyceraldehyde and dihydroxyacetone during storage.

摘要翻译： 本发明描述了一种生产以植物油或脂肪为原料的甘油的制备方法，从植物油或脂肪中获得粗甘油，并用还原剂处理粗甘油。 本发明还描述了制备药物或药物组合物的方法，所述药物或组合物通过将甘油与至少一种药物活性成分组合而形成。 本发明还描述了由通过本发明获得的甘油和药物活性成分组成的药物组合物或药物，该组合物在储存期间形成非常少的甘油醛和二羟基丙酮。

公开(公告)号：US20070231902A1

公开(公告)日：2007-10-04

申请号：US11595538

申请日：2006-11-10

申请人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

发明人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

IPC分类号： C12N5/02

CPC分类号： C12N5/0037 ,  C12N2500/36 ,  C12N2500/72 ,  C12N2500/76 ,  C12N2500/82 ,  C12N2500/90

摘要： The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24 carbon atoms and 2 to 5 double bonds as the acid component and a lower C1-4 alcohol, preferably ethanol, or a sterol as ester component. In another aspect, the esters comprise a transesterification product of natural or synthetic oils or a mixture of such oils having greater than 50 mol-% of unsaturated, physiologically active fatty acids, based on the acyl group, and a lower C1-4 alcohol or a sterol. In a further aspect, the esters are used together with sterols, phospholipids and/or vegetable proteins or are liposomally encapsulated.

摘要翻译： 所公开的发明涉及使用不饱和生理活性脂肪酸的酯作为细胞培养的营养培养基，更特别地，作为胎牛血清的替代物。 在一个方面，酯包含大于50mol％的含有16-24个碳原子和2-5个双键的生理活性脂肪酸作为酸组分和较低C 1-4醇， 优选乙醇，或作为酯组分的甾醇。 另一方面，酯包括天然或合成油的酯交换产物或具有大于50摩尔％的基于酰基的不饱和的生理活性脂肪酸的这种油的混合物，以及较低的C 1 -4醇或甾醇。 在另一方面，酯与甾醇，磷脂和/或植物蛋白质一起使用或被脂质体包封。

公开(公告)号：US20060233986A1

公开(公告)日：2006-10-19

申请号：US10544023

申请日：2003-12-19

申请人： Bernhard Gutsche ,  Gerhard Wollmann ,  Albert Strube ,  Eike Mahnke

发明人： Bernhard Gutsche ,  Gerhard Wollmann ,  Albert Strube ,  Eike Mahnke

IPC分类号： B32B27/32

CPC分类号： C09K5/063 ,  A61F2007/0292 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y02E60/147 ,  Y10T428/1334

摘要： This disclosure relates to a heat or cold storage composition comprising at least one continuous and at least one discontinuous phase, the continuous phase being liquid or at least plastic at a temperature of −10 to 50° C. and the discontinuous phase—present in the continuous phase—being particulate and containing as phase change material (PCM) at least 10% by weight of an organic compound with a melting point of 0 to 50° C. and at least one structuring polymeric compound. It also relates to the use of a composition according to the invention for controlled heating/cooling by phase change and to a device for the controlled heating/cooling of an object by phase change at least comprising a container for holding a composition according to the invention.

摘要翻译： 本公开涉及包含至少一个连续和至少一个不连续相的热或冷储存组合物，所述连续相是液体或在-10至50℃的温度下至少是塑料，并且所述不连续相存在于 连续相分散的颗粒并含有至少10重量％的熔点为0至50℃的有机化合物和至少一种结构化聚合化合物作为相变材料（PCM）。 它还涉及根据本发明的组合物用于通过相变的受控加热/冷却以及通过相变的用于受控加热/冷却物体的装置的用途，所述相变至少包括用于保持根据本发明的组合物的容器 。

公开(公告)号：US20060099158A1

公开(公告)日：2006-05-11

申请号：US10517891

申请日：2003-06-03

申请人： Lars Zander ,  Albert Strube ,  Norbert Huebner ,  Alfred Westfechtel

发明人： Lars Zander ,  Albert Strube ,  Norbert Huebner ,  Alfred Westfechtel

IPC分类号： A61K31/045 ,  A61K8/34

CPC分类号： A61Q19/06 ,  A23L33/12 ,  A61K8/342 ,  A61Q17/04

摘要： Compositions comprising at least one conjugated linoleyl alcohol component selected from the group consisting of cis- and trans-isomers of 6,8-octadecadienol, 7,9-octadecadienol, 8,10-octadecadienol, 9, 11-octadecadienol, 10,12-octadecadienol and 11,13-octadecadienol are described along with their use in oral and topical applications for humans and animals.

摘要翻译： 包含至少一种共轭亚油醇组分的组合物，其选自6,8-十八碳二烯醇，7,9-十八碳二烯醇，8,10-十八碳二烯醇，9,11-十八碳二烯醇，10,12-二十八烷二醇的顺式和反式异构体， 描述了十八碳二烯醇和11,13-十八碳二烯酚及其在人和动物的口服和局部应用中的用途。

公开(公告)号：US06762313B2

公开(公告)日：2004-07-13

申请号：US10380564

申请日：2003-03-13

申请人： Albert Strube ,  Uwe Hoemmerich ,  Bernhard Gutsche

发明人： Albert Strube ,  Uwe Hoemmerich ,  Bernhard Gutsche

IPC分类号： C11C100

CPC分类号： C11C3/04 ,  C11B3/12 ,  C11C3/10

摘要： Processes for preparing linoleic acid raw materials are described wherein the processes comprise: (a) transesterifying a triglyceride component with an alcohol having from 1 to 4 carbon atoms, at a temperature of from 80 to 120° C., to form a transesterification mixture comprising linoleic acid esters and one or more by-products selected from the group consisting of glycerides, free glycerol, and soaps, wherein the triglyceride component is comprised of at least 60% by weight linoleic acid; and (b) removing the one or more by-products from the transesterification mixture.

摘要翻译： 描述了制备亚油酸原料的方法，其中所述方法包括：（a）在80至120℃的温度下将甘油三酯组分与具有1至4个碳原子的醇进行酯交换以形成酯交换混合物，其包含 亚油酸酯和选自甘油酯，游离甘油和皂的一种或多种副产物，其中甘油三酯组分由至少60重量％的亚油酸组成; 和（b）从酯交换混合物中除去一种或多种副产物。