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公开(公告)号:US08372852B2
公开(公告)日:2013-02-12
申请号:US13470122
申请日:2012-05-11
IPC分类号: C07D473/28 , C07D473/34 , A61K31/52 , A61P31/18 , C07D487/04 , A61K31/519
CPC分类号: C07D487/04 , C07D473/18
摘要: Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders. In some embodiments, the enzyme inhibitors are compounds of formula (I) or a pharmaceutically acceptable salt or tautomer thereof:
摘要翻译: 本文描述的是新的酶抑制剂。 在一些实施方案中,酶抑制剂是逆转录酶抑制剂,特别是HIV逆转录酶抑制剂。 本文还描述了含有它们的组合物和使用它们的方法。 因此,本文所述的化合物和组合物可用于体外和体内抑制HIV逆转录酶,作为治疗或预防HIV,AIDS或相关病症的方法。 在一些实施方案中,酶抑制剂是式(I)的化合物或其药学上可接受的盐或互变异构体:
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公开(公告)号:US08207178B2
公开(公告)日:2012-06-26
申请号:US12334371
申请日:2008-12-12
IPC分类号: C07D487/04 , A61K31/519 , A61P31/18 , C07D473/30 , A61K31/52
CPC分类号: C07D487/04 , C07D473/18
摘要: Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders. In some embodiments, the enzyme inhibitors are compounds of formula (I) or a pharmaceutically acceptable salt or tautomer thereof:
摘要翻译: 本文描述的是新的酶抑制剂。 在一些实施方案中,酶抑制剂是逆转录酶抑制剂,特别是HIV逆转录酶抑制剂。 本文还描述了含有它们的组合物和使用它们的方法。 因此,本文所述的化合物和组合物可用于体外和体内抑制HIV逆转录酶,作为治疗或预防HIV,AIDS或相关病症的方法。 在一些实施方案中,酶抑制剂是式(I)的化合物或其药学上可接受的盐或互变异构体:
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公开(公告)号:US20090162319A1
公开(公告)日:2009-06-25
申请号:US12334371
申请日:2008-12-12
IPC分类号: A61K31/519 , C07D487/04 , C07D473/30 , A61K31/708 , A61K38/21 , A61P31/12 , A61K31/538 , A61K31/5377 , A61K31/52
CPC分类号: C07D487/04 , C07D473/18
摘要: Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders.
摘要翻译: 本文描述的是新的酶抑制剂。 在一些实施方案中,酶抑制剂是逆转录酶抑制剂,特别是HIV逆转录酶抑制剂。 本文还描述了含有它们的组合物和使用它们的方法。 因此,本文所述的化合物和组合物可用于体外和体内抑制HIV逆转录酶,作为治疗或预防HIV,AIDS或相关病症的方法。
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公开(公告)号:US20120277206A1
公开(公告)日:2012-11-01
申请号:US13470122
申请日:2012-05-11
CPC分类号: C07D487/04 , C07D473/18
摘要: Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders.
摘要翻译: 本文描述的是新的酶抑制剂。 在一些实施方案中,酶抑制剂是逆转录酶抑制剂,特别是HIV逆转录酶抑制剂。 本文还描述了含有它们的组合物和使用它们的方法。 因此,本文所述的化合物和组合物可用于体外和体内抑制HIV逆转录酶,作为治疗或预防HIV,AIDS或相关病症的方法。
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