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公开(公告)号：US08283361B2
公开(公告)日：2012-10-09
申请号：US12477781
申请日：2009-06-03
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D417/14 , C07D498/06
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US08569484B2
公开(公告)日：2013-10-29
申请号：US13322717
申请日：2010-05-28
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04
摘要： Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述了式（IA）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20100190745A1
公开(公告)日：2010-07-29
申请号：US12477781
申请日：2009-06-03
IPC分类号： A61K31/695 , C07D215/20 , A61K31/4709 , C07D498/02 , A61K31/5383 , A61K31/397 , C07D401/14 , A61K31/496 , C07D413/14 , A61K31/5377 , C07F7/02 , A61P31/04
CPC分类号： C07D417/14 , C07D498/06
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述式（I）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20090221655A1
公开(公告)日：2009-09-03
申请号：US12278006
申请日：2007-01-22
IPC分类号： A61K31/422 , C07D413/10 , A61P31/04
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides a compound of Formula (I) Or a pharmaceutically acceptable salt thereof wherein: W is CH2NHC(═Z)R1, C(═Z)NHR2, or CH2het; X is H, C1-6alkyl, or C2-6alkenyl; Y is H, or F; Z is O, or S; R1 is C1-6alkyl, NHC1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, or OC1-4alkyl; R2 is H, C1-4alkyl, or —OC1-4alkyl; and het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring, wherein each carbon atom in het is optionally substituted with C1-4alkyl, C2-4alkenyl, C2-4alkynyl, halo, OR3, CN, NO2, NHR3R3, oxo, CF3, OCF3, C(═O)C1-4alkyl, OC(═O)C1-4alkyl, or C(═O)OR3; wherein R3 is H, or C1-4alkyl.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中：W是CH 2 NHC（-Z）R 1，C（-Z）NHR 2或CH 2 het; X是H，C 1-6烷基或C 2-6烯基; Y是H或F; Z是O或S; R 1是C 1-6烷基，NHC 1-6烷基，C 3-7环烷基，C 2-6烯基或OC 1-4烷基; R2是H，C1-4烷基或-OC1-4烷基; 并且het是在环内具有1-4个选自氧，硫和氮的1-4个杂原子的五（5）或六（6）元杂环，其中每个碳原子在任何位置任选被C1取代 （O）C 1-4烷基，或C（-O（O）） - ， - （C 1-4）烷基，C 1-4烷基，C 2-4烯基，C 2-4炔基，卤素，OR 3，CN，NO 2，NHR 3 R 3，氧代，CF 3，OCF 3，C ）OR3; 其中R 3是H或C 1-4烷基。
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公开(公告)号：US07265140B2
公开(公告)日：2007-09-04
申请号：US10937187
申请日：2004-09-09
申请人： Vara Prasad Venkata Nagendra Josyula , Robert C. Gadwood , Lisa Marie Thomasco , Ji-Young Kim , Allison Laura Choy , Frederick Earl Boyer
发明人： Vara Prasad Venkata Nagendra Josyula , Robert C. Gadwood , Lisa Marie Thomasco , Ji-Young Kim , Allison Laura Choy , Frederick Earl Boyer
IPC分类号： A61K31/422 , C07D263/04
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.
摘要翻译： 本发明涉及酰氧基甲基氨基甲酸酯恶唑烷酮。 本发明的化合物对革兰氏阳性和革兰氏阴性菌具有优异的口服生物利用度的有效活性。
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公开(公告)号：US20120122817A1
公开(公告)日：2012-05-17
申请号：US13322717
申请日：2010-05-28
IPC分类号： A61K31/4545 , C07F9/6561 , A61K31/675 , A61K31/5377 , A61P13/02 , A61K31/541 , A61P31/04 , A61P17/00 , A61P11/08 , A61P11/02 , C07D471/04 , A61K31/496
CPC分类号： C07D471/04
摘要： Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述了式（IA）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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公开(公告)号：US20100317624A1
公开(公告)日：2010-12-16
申请号：US12794894
申请日：2010-06-07
申请人： Allison Laura CHOY , Ann EAKIN , Olga QUIROGA , Brian SHERER
发明人： Allison Laura CHOY , Ann EAKIN , Olga QUIROGA , Brian SHERER
IPC分类号： A61K31/675 , C07D417/14 , A61K31/4709 , C07F9/6558 , A61K31/496 , C07D487/08 , A61K31/4995 , A61K31/5377 , A61P31/04
CPC分类号： C07D417/14
摘要： Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译： 描述了式（IA）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。
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