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    Prostate cancer-related nucleic acids
    2.
    发明授权
    Prostate cancer-related nucleic acids 有权
    前列腺癌相关核酸

    公开(公告)号：US07642348B2

    公开(公告)日：2010-01-05

    申请号：US11429720

    申请日：2006-05-08

    申请人： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

    发明人： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

    IPC分类号： C07H21/04

    CPC分类号： C12Q1/6886 ,  C07K14/4748 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Described herein are novel polynucleotides associated with prostate cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of prostate cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.

    摘要翻译： 本文描述了与前列腺癌相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于诊断，预后和治疗前列腺癌的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。

    Liver cancer-related nucleic acids
    8.
    发明申请
    Liver cancer-related nucleic acids 有权
    肝癌相关核酸

    公开(公告)号：US20070259350A1

    公开(公告)日：2007-11-08

    申请号：US11418875

    申请日：2006-05-04

    申请人： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

    发明人： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/02 ,  C12M3/00

    CPC分类号： C12Q1/6886 ,  C07K14/4748 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of liver cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.

    摘要翻译： 本文描述的是与肝癌相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于肝癌诊断，预后和治疗的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。

    BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY VIRAL AND VIRAL ASSOCIATED OLIGONUCLEOTIDES AND USES THEREOF
    9.
    发明申请
    BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY VIRAL AND VIRAL ASSOCIATED OLIGONUCLEOTIDES AND USES THEREOF 有权
    生物检测组织的新型法规和病毒相关的寡核苷酸及其用途

    公开(公告)号：US20070042381A1

    公开(公告)日：2007-02-22

    申请号：US10709739

    申请日：2004-05-26

    申请人： Itzhak Bentwich ,  Amir Avniel

    发明人： Itzhak Bentwich ,  Amir Avniel

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/1132 ,  C07K14/005 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2740/16022 ,  Y02A90/26

    摘要： The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known “target” genes, many of which are known to be involved in various viral diseases. Nucleic acid molecules are provided respectively encoding 1,655 viral and 105,537 human GAM precursor oligonucleotides, and 190 viral and 14,813 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

    摘要翻译： 本发明涉及第一组新的病毒和人类相关寡核苷酸，这里被鉴定为“基因组地址信使”或“GAM”寡核苷酸，以及第二组新的操纵子样病毒和人多核苷酸，这里被鉴定为“基因组记录 “或”GR“多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种病毒性疾病。 提供分别编码1,655个病毒和105,537个人GAM前体寡核苷酸的核酸分子，以及190个病毒和14,813个人GR多核苷酸，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统以及特异性 功能和用途，用于检测GAM寡核苷酸和GR多核苷酸的表达，并用于选择性增强和选择性抑制其各自靶基因的翻译。