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公开(公告)号:US20120208818A1
公开(公告)日:2012-08-16
申请号:US13269697
申请日:2011-10-10
申请人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
发明人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC分类号: A61K31/5377 , C07D405/14 , A61K31/517 , A61K31/4439 , A61K31/4184 , A61K31/416 , A61K31/502 , C07D471/04 , A61K31/4725 , C07D401/14 , C07D403/14 , C07D413/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/435
CPC分类号: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
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公开(公告)号:US08067415B2
公开(公告)日:2011-11-29
申请号:US12084353
申请日:2006-10-26
申请人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
发明人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC分类号: A61K31/505 , A61K31/498 , A61K31/435 , A61K31/4184 , C07D487/22 , C07D487/12 , C07D241/00 , C07D491/14 , C07D491/22 , C07D235/04
CPC分类号: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供了通式(I)的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US20090197884A1
公开(公告)日:2009-08-06
申请号:US12084356
申请日:2006-10-26
申请人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: A61K31/454 , C07D401/06 , C07D401/14 , C07D413/14 , C07D405/14 , A61P29/00 , A61K31/4545 , A61K31/517 , A61K31/423 , A61K31/416 , A61K31/5377
CPC分类号: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供通式I的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US07541365B2
公开(公告)日:2009-06-02
申请号:US11595653
申请日:2006-11-10
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D455/04 , C07D491/00 , C07D221/00 , C07D221/06
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US07186729B2
公开(公告)日:2007-03-06
申请号:US10487168
申请日:2002-11-13
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof
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公开(公告)号:US20100016289A1
公开(公告)日:2010-01-21
申请号:US12084357
申请日:2006-10-26
申请人: Kevin Sprott , Prakash Raman , Shomir Ghosh , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Kevin Sprott , Prakash Raman , Shomir Ghosh , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: A61K31/55 , C07D403/02 , C07D413/14 , A61P9/00 , C07D403/14 , A61P3/10 , A61P37/00 , A61K31/517
CPC分类号: C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要: The present invention provides compounds of general formula I: (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供了通式I的化合物:(I)或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US20090163497A1
公开(公告)日:2009-06-25
申请号:US12084353
申请日:2006-10-26
申请人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
发明人: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC分类号: A61K31/5377 , C07D403/04 , C07D413/14 , C07D403/14 , C07D409/14 , C07D405/14 , A61K31/498 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/421 , A61P19/02 , A61P17/00 , A61P29/00 , A61P9/10 , A61P3/10
CPC分类号: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供了通式(I)的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US07271176B2
公开(公告)日:2007-09-18
申请号:US10487168
申请日:2002-11-13
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
CPC分类号: C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由式(1)表示的化合物或其生理学上可接受的盐
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公开(公告)号:US20120214807A1
公开(公告)日:2012-08-23
申请号:US13281482
申请日:2011-10-26
申请人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: A61K31/5377 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/454 , A61K31/453 , A61K31/4439 , C07D471/04 , C07D405/14 , C07D413/14 , C07D405/04 , C07D409/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/5025
CPC分类号: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供通式I的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US20120046311A1
公开(公告)日:2012-02-23
申请号:US13245436
申请日:2011-09-26
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A61K31/4353 , A61P19/02 , A61P9/10 , A61P3/10 , A61P29/00 , A61P25/00 , A61P1/00 , A61P37/08 , A61P11/06 , C07D491/044 , A61P17/06
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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