公开(公告)号：US07473792B2

公开(公告)日：2009-01-06

申请号：US11666922

申请日：2005-12-05

申请人： Jeroen Boogers ,  Ulfried Felfer ,  Martina Kotthaus ,  Andreas H. M. De Vries ,  Johannes G. De Vries ,  Laurent Lefort ,  Gerhard Steinbauer

发明人： Jeroen Boogers ,  Ulfried Felfer ,  Martina Kotthaus ,  Andreas H. M. De Vries ,  Johannes G. De Vries ,  Laurent Lefort ,  Gerhard Steinbauer

IPC分类号： C07F15/00 ,  B01J31/00 ,  C07C57/02

CPC分类号： C07C51/36 ,  B01J31/1865 ,  B01J31/187 ,  B01J31/24 ,  B01J2231/645 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07C67/303 ,  C07C57/36 ,  C07C57/58 ,  C07C53/128 ,  C07C59/64

摘要： A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

摘要翻译： R 1为H或任选取代的烷基，芳基或杂芳基的式（I）的丙烯酸衍生物的过渡金属催化不对称氢化的方法，R 2为任选取代的烷基，芳基或杂芳基，R 3为 是H或C 1 -C 6烷基，其包括在一个或多个氢供体存在下，任选地在溶剂中使式（I）化合物氢化，使用包含过渡金属 钌，铑和铱以及式（II）的手性磷配体的组合，其中Cn与两个氧原子和磷原子一起形成任选取代的具有2至6个碳原子的环，R 4是 任选取代的烷基，芳基，烷氧基或芳氧基或NR5R6，其中R5和R6各自独立地为H或任选取代的烷基，芳基，芳烷基或烷芳基，或与氮原子一起形成 g和其中R是任选取代的烷基或芳基的式（III）的非手性膦配体与相应的式（IV）化合物反应，其中R 1，R 2和R 3各自如上所定义，以及 一种用于不对称过渡金属催化的新型催化剂体系。