公开(公告)号：US08155422B2

公开(公告)日：2012-04-10

申请号：US12293835

申请日：2007-03-15

Applicant: Andy Ziegler ,  Ewald Roessl

Inventor： Andy Ziegler ,  Ewald Roessl

IPC: G06K9/00

CPC classification number: G01T1/2985

Abstract: It is described a method for dynamically optimizing the signal-to-noise ratio of attenuation data related to two different X-ray energies for reconstructing an image of an object under examination. The method comprises (a) estimating the thickness and the material composition of the object at a plurality of different projection angles, (b) for each of the various projection angles calculating for a variety of combinations of different first and second X-ray energies a corresponding common signal-to-noise ratio, (c) for each of the various projection angles choosing the first and the second X-ray energy causing the maximum corresponding common signal-to-noise ratio, and (d) for each of the various projection angles acquiring X-ray attenuation data of the object whereby the two X-ray energies are the X-ray energies causing a maximum signal-to-noise ratio assigned to the respective projection angle.

Abstract translation: 描述了一种用于动态优化与两个不同X射线能量相关的衰减数据的信噪比的方法，用于重建被检查物体的图像。 该方法包括：（a）以多个不同的投影角度估计物体的厚度和材料成分，（b）对于针对不同的第一和第二X射线能量的各种组合计算的各种投影角度中的每一个 相应的公共信噪比，（c）对于选择第一和第二X射线能量的各种投影角度中的每一个引起最大相应的公共信噪比，（d）对于各种各样的 投影角度获取物体的X射线衰减数据，由此两个X射线能量是分配给各个投影角度的最大信噪比的X射线能量。

公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

Applicant: Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

Inventor： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC: G01N21/49 ,  G01N21/00

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

Abstract translation: 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20100232669A1

公开(公告)日：2010-09-16

申请号：US12293835

申请日：2007-03-15

Applicant: Andy Ziegler ,  Ewald Roessl

Inventor： Andy Ziegler ,  Ewald Roessl

IPC: G06K9/00

CPC classification number: G01T1/2985

Abstract: It is described a method for dynamically optimizing the signal-to-noise ratio of attenuation data related to two different X-ray energies for reconstructing an image of an object under examination. The method comprises (a) estimating the thickness and the material composition of the object at a plurality of different projection angles, (b) for each of the various projection angles calculating for a variety of combinations of different first and second X-ray energies a corresponding common signal-to-noise ratio, (c) for each of the various projection angles choosing the first and the second X-ray energy causing the maximum corresponding common signal-to-noise ratio, and (d) for each of the various projection angles acquiring X-ray attenuation data of the object whereby the two X-ray energies are the X-ray energies causing a maximum signal-to-noise ratio assigned to the respective projection angle.

Abstract translation: 描述了一种用于动态优化与两个不同X射线能量相关的衰减数据的信噪比的方法，用于重建被检查物体的图像。 该方法包括：（a）以多个不同的投影角度估计物体的厚度和材料成分，（b）对于针对不同的第一和第二X射线能量的各种组合计算的各种投影角度中的每一个 相应的公共信噪比，（c）对于选择第一和第二X射线能量的各种投影角度中的每一个引起最大相应的公共信噪比，（d）对于各种各样的 投影角度获取物体的X射线衰减数据，由此两个X射线能量是分配给各个投影角度的最大信噪比的X射线能量。

公开(公告)号：US07672424B2

公开(公告)日：2010-03-02

申请号：US11575902

申请日：2005-09-22

Applicant: Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

Inventor： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

IPC: A61B6/00

CPC classification number: G06T11/006

Abstract: A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

Abstract translation: 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US20100030084A1

公开(公告)日：2010-02-04

申请号：US12514589

申请日：2007-11-12

Applicant: Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

Inventor： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC: A61B6/00 ,  G06K9/00

CPC classification number: A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

Abstract: The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

公开(公告)号：US07596203B2

公开(公告)日：2009-09-29

申请号：US11575716

申请日：2005-10-06

Applicant: Thomas Koehler ,  Andy Ziegler

Inventor： Thomas Koehler ,  Andy Ziegler

IPC: A61B6/00

CPC classification number: A61B6/032 ,  A61B6/027

Abstract: The invention relates to a computer tomography method with a circular relative movement between the beam source and an iterative reconstruction method suitable therefor. The reconstruction method is substantially improved by deriving the first approximation image from a CT image, which is obtained from a prior acquisition during helical relative movement.

Abstract translation: 本发明涉及一种计算机断层摄影方法，其具有在光束源之间的圆周相对运动和适合于其的迭代重建方法。 通过从螺旋相对运动期间的先前获取获得的CT图像导出第一近似图像，实质上改进了重建方法。

公开(公告)号：US07526060B2

公开(公告)日：2009-04-28

申请号：US10598663

申请日：2005-03-08

Applicant: Andy Ziegler

Inventor： Andy Ziegler

IPC: A61B6/00

CPC classification number: G06T11/006 ,  A61B6/5258 ,  G06T2211/424

Abstract: The reconstruction of images of an object of interest may introduce artifacts along lines of high gradients of absorption values. According to an exemplary embodiment of the present invention, these artifacts may efficiently be removed by a statistical weighing during reconstruction of the image. Advantageously, according to an aspect of the present invention, the reconstruction of the image may be performed iteratively, wherein the updates are weighted with the intrinsic statistical error of the measured photon counts. This may lead to an efficient removal of artifacts.

Abstract translation: 感兴趣对象的图像的重建可以沿着吸收值的高梯度线引入人为因素。 根据本发明的示例性实施例，通过在重建图像期间的统计称重可以有效地去除这些伪影。 有利地，根据本发明的一个方面，可以迭代地执行图像的重建，其中使用所测量的光子计数的固有统计误差对更新进行加权。 这可能导致有效地去除伪影。

公开(公告)号：US20080187195A1

公开(公告)日：2008-08-07

申请号：US11911214

申请日：2006-04-10

Applicant: Thomas Kohler ,  Roland Proksa ,  Andy Ziegler

Inventor： Thomas Kohler ,  Roland Proksa ,  Andy Ziegler

IPC: G06K9/00

CPC classification number: G06T11/008 ,  G06T11/006

Abstract: The invention relates to an examination apparatus with an X-ray device (10) for circular or helical cone-beam CT acquisition of projections images (Pi(E1), Pi(E2)) of a patient (1) with different energy spectra (E1, E2) and/or with an energy-resolved detection. By a combination of the projections, images (Ibone,i, Itissue,i) can be calculated that show predominantly the bone structure and the soft tissue, respectively. Therefore, a 3D model (Mbone) of the bone structure and a 3D model (Mtissue) of the tissue can be reconstructed separately. After removal of artifacts from the bone-structure model (Mbone), both separate 3D models can be integrated to a combined model (M) of the body volume with a high image quality.

Abstract translation: 本发明涉及一种具有X射线装置（10）的检查装置，用于对投影图像进行圆形或螺旋锥束CT采集（P 1） 具有不同能量谱的患者（1）的患者（1）的患者（E 2） >）和/或能量分辨检测。 通过投影的组合，可以分别计算主要表现为骨骼结构和软组织的图像（I骨，I，I，I组织，i）。 因此，可以分别重建组织的骨骼结构的3D模型（M＆gt;骨头）和3D模型（M＆gt;组织）。 在从骨结构模型（骨骼）中去除人造物之后，两个分开的3D模型可以被整合到具有高图像质量的身体体积的组合模型（M）上。

公开(公告)号：US20080095305A1

公开(公告)日：2008-04-24

申请号：US11718724

申请日：2005-11-02

Applicant: Andy Ziegler ,  Thomas Koehler ,  Michael Grass

Inventor： Andy Ziegler ,  Thomas Koehler ,  Michael Grass

IPC: A61B6/03

CPC classification number: G01T1/2985 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4241 ,  A61B6/482 ,  A61B6/483 ,  G01V5/0025 ,  G01V5/005 ,  G06T11/006 ,  G06T2211/424

Abstract: A computer tomography apparatus (100) for examination of an object of interest (107), the computer tomography apparatus (100) comprising detecting elements (123) adapted to detect electromagnetic radiation coherently scattered from an object of interest (107) in an energy-resolving manner, and a determination unit (118) adapted to determine structural information concerning the object of interest (107) based on a statistical analysis of detecting signals received from the detecting elements (123).

Abstract translation: 一种用于检查感兴趣对象（107）的计算机断层摄影装置（100），所述计算机断层摄影装置（100）包括检测元件（123），所述检测元件适于检测能量相关物体（107）相干散射的电磁辐射， 以及确定单元（118），其适于基于从所述检测元件（123）接收的检测信号的统计分析来确定关于感兴趣对象的结构信息（107）。

公开(公告)号：US08000434B2

公开(公告)日：2011-08-16

申请号：US12373112

申请日：2007-07-02

Applicant: Andy Ziegler ,  Roland Proksa

Inventor： Andy Ziegler ,  Roland Proksa

IPC: A61B6/00

CPC classification number: G01T1/2985

Abstract: A computed tomography system includes an x-ray source (108) that rotates about and emits radiation through an imaging region (116). At least one finite energy resolution detector (112) detects the emitted radiation. The at least one finite resolution detector (112) includes a plurality of sub-detectors (204). Each of the plurality of sub-detectors (204) is associated with one or more different energy thresholds. Each of the energy thresholds is used to count a number of incident photons based on a corresponding energy level. A reconstruction system (136) reconstructs the photon counts to generate one or more images of a subject residing within the imaging region (116).

Abstract translation: 计算机断层摄影系统包括绕着成像区域（116）旋转并发射辐射的x射线源（108）。 至少一个有限能量分辨率检测器（112）检测发射的辐射。 所述至少一个有限分辨率检测器（112）包括多个子检测器（204）。 多个子检测器（204）中的每一个与一个或多个不同的能量阈值相关联。 每个能量阈值用于根据相应的能级对一些入射光子进行计数。 重建系统（136）重建光子计数以产生驻留在成像区域（116）内的对象的一个​​或多个图像。