专利检索 ap:"Anne Mengel" 第 1 页

1.

发明授权
Alkynylpyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same 有权

公开(公告)号：US08524724B2

公开(公告)日：2013-09-03

申请号：US12142279

申请日：2008-06-19

申请人： Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer

发明人： Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer

IPC分类号： A01N43/54 , A61K31/505 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/02

摘要： The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.

2.

发明授权
Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译：多取代四氢萘衍生物，其制备方法及其作为抗炎剂的用途

公开(公告)号：US08097627B2

公开(公告)日：2012-01-17

申请号：US12642121

申请日：2009-12-18

申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

IPC分类号： A61K31/50 , A61K31/517 , A61K31/47 , C07D237/30 , C07D287/72 , C07D217/22 , C07D215/02

CPC分类号： C07D217/24 , A61K31/47 , A61K31/472 , A61K31/517 , C07C215/44 , C07C255/58 , C07C2602/10 , C07D209/34 , C07D209/46 , C07D213/74 , C07D215/04 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D215/58 , C07D231/56 , C07D237/32 , C07D239/74 , C07D239/76 , C07D277/64 , C07D307/88 , C07D317/70 , C07D405/12 , C07D471/04

摘要： The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.

摘要翻译： 本发明涉及式（I）的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。

3.

发明申请
Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs 审中-公开
标题翻译：三环氨基醇，其合成方法和使用与抗炎药物相同

公开(公告)号：US20060167025A1

公开(公告)日：2006-07-27

申请号：US11312655

申请日：2005-12-21

申请人： Markus Berger , Norbert Schmees , Heike Schaecke , Stefan Baurle , Hartmut Rehwinkel , Anne Mengel , Konrad Krolikiewicz , Danja Grossbach , David Voigtlaender

发明人： Markus Berger , Norbert Schmees , Heike Schaecke , Stefan Baurle , Hartmut Rehwinkel , Anne Mengel , Konrad Krolikiewicz , Danja Grossbach , David Voigtlaender

IPC分类号： A61K31/517 , A61K31/403 , A61K31/381 , A61K31/343

CPC分类号： C07D409/12 , C07D405/12

摘要： The invention relates to tricyclic amino alcohols of general formula (I) method for synthesis of same and use of same as anti-inflammatory agents.

摘要翻译： 本发明涉及通式（I）的合成方法的三环氨基醇及其与抗炎剂的用途。

4.

发明申请
Inhibitors of soluble adenylate cyclase 审中-公开
标题翻译：可溶性腺苷酸环化酶抑制剂

公开(公告)号：US20060074084A1

公开(公告)日：2006-04-06

申请号：US11233533

申请日：2005-09-23

申请人： Duy Nguyen , Anne Mengel , Martin Fritsch , Gernor Langer , Ulf Boemer , Knut Eis , Bernd Menzenbach , Bernd Buchmann , Seock-Kyu Khim

发明人： Duy Nguyen , Anne Mengel , Martin Fritsch , Gernor Langer , Ulf Boemer , Knut Eis , Bernd Menzenbach , Bernd Buchmann , Seock-Kyu Khim

IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/405 , C07D413/02 , C07D405/02 , C07D403/02

CPC分类号： C07D405/12 , C07D209/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D417/12

摘要： The invention relates to compounds of general formula I as well as their production and use as a medication.

摘要翻译： 本发明涉及通式I的化合物及其作为药物的生产和用途。

5.

发明申请
Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开
标题翻译：多取代四氢萘衍生物，其制备方法及其作为抗炎剂的用途

公开(公告)号：US20050222154A1

公开(公告)日：2005-10-06

申请号：US10961375

申请日：2004-10-12

申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

IPC分类号： A61K31/498 , A61K31/502 , A61K31/517 , A61K31/538

CPC分类号： C07D217/24 , C07D215/227 , C07D237/32 , C07D239/74

摘要： The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.

摘要翻译： 本发明涉及式（I）的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。

6.

发明申请
Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译：四氢萘衍生物，其生产方法及其作为抗炎剂的用途

公开(公告)号：US20050209324A1

公开(公告)日：2005-09-22

申请号：US10961406

申请日：2004-10-12

申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

IPC分类号： A61K31/135 , A61K31/195 , A61K31/277

CPC分类号： C07D209/34 , C07D213/74 , C07D215/04 , C07D215/227 , C07D215/38 , C07D215/60 , C07D217/24 , C07D231/56 , C07D237/32 , C07D239/74 , C07D277/64 , C07D307/88 , C07D405/12 , C07D471/04

摘要： The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.

摘要翻译： 本发明涉及四氢萘衍生物，其制备方法及其作为抗炎剂的用途。

7.

发明申请
Rearranged pentanols, a process for their production and their use as anti-inflammatory agents 失效
标题翻译：重排戊醇，其生产过程及其作为抗炎剂的用途

公开(公告)号：US20050131226A1

公开(公告)日：2005-06-16

申请号：US10960757

申请日：2004-10-08

申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa

IPC分类号： A61P29/00 , C07D209/46 , C07D215/38 , C07D231/56 , C07D237/32 , C07D239/74 , C07D277/68 , C07D311/76 , C07D471/02 , C07D498/02

CPC分类号： C07D209/46 , C07D215/38 , C07D231/56 , C07D237/32 , C07D239/74 , C07D311/76

摘要： The invention relates to the compounds of formula I, a process for their production and their use as anti-inflammatory agents.

摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。

8.

发明授权
Sulphoximine-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments 有权
标题翻译：磺酰亚胺取代的喹唑啉衍生物作为免疫调节剂，其制备和用作药物

公开(公告)号：US07863283B2

公开(公告)日：2011-01-04

申请号：US12138879

申请日：2008-06-13

申请人： Duy Nguyen , Arne von Bonin , Michael Haerter , Hartmut Schirok , Anne Mengel , Martina Schaefer , Oliver von Ahsen

发明人： Duy Nguyen , Arne von Bonin , Michael Haerter , Hartmut Schirok , Anne Mengel , Martina Schaefer , Oliver von Ahsen

IPC分类号： A61K31/517

CPC分类号： C07D239/94 , C07C381/10 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12

摘要： The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.

摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的喹唑啉衍生物，其制备方法及其作为治疗各种疾病的药物的用途。