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公开(公告)号:US08318791B2
公开(公告)日:2012-11-27
申请号:US12455798
申请日:2009-06-05
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20120208815A1
公开(公告)日:2012-08-16
申请号:US12449701
申请日:2008-03-03
申请人: Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Comelia Bellamacina , Kay Huh , Gordana Atallah , Christopher Mcbride , William Antonios-Mccrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
发明人: Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Comelia Bellamacina , Kay Huh , Gordana Atallah , Christopher Mcbride , William Antonios-Mccrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
IPC分类号: A61K31/5377 , A61K31/4545 , A61P35/00 , C07D413/14 , A61K31/496 , C07D417/14 , A61K31/506 , A61K31/497 , C07D401/14 , C12N5/071
CPC分类号: C07D401/12 , C07D213/78 , C07D239/28
摘要: New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译: 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物,组合物和方法。 在某些实施方案中,化合物和组合物有效抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。
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公开(公告)号:US20090258016A1
公开(公告)日:2009-10-15
申请号:US12455798
申请日:2009-06-05
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174 , A61P35/00
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US07470701B2
公开(公告)日:2008-12-30
申请号:US11095993
申请日:2005-03-30
申请人: Xiaodong Lin , Alice Rico , Xiaojing Michael Wang , Yasheen Zhou , Ann B. Jefferson , Annette Walter
发明人: Xiaodong Lin , Alice Rico , Xiaojing Michael Wang , Yasheen Zhou , Ann B. Jefferson , Annette Walter
IPC分类号: A61K31/506 , C07D401/04 , C07D239/42
CPC分类号: C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要: The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的五元化合物及其药学上可接受的盐,酯或前药,新化合物的组合物以及药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20060089321A1
公开(公告)日:2006-04-27
申请号:US10504487
申请日:2003-02-12
IPC分类号: A61K48/00
CPC分类号: C07K14/4702 , A61K38/00 , C12N15/1136 , C12N2310/11 , C12N2310/12
摘要: Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
摘要翻译: 提供人Cks1和人Skp2的抑制剂,包括对人Cks1和人Skp2特异性的反义寡核苷酸,方法和组合物。 还提供了使用组合物调节Cks1表达和Skp2表达以及调节细胞生长,特别是肿瘤细胞生长的方法。
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公开(公告)号:US08822497B2
公开(公告)日:2014-09-02
申请号:US12449701
申请日:2008-03-03
申请人: Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
发明人: Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
IPC分类号: A61K31/4545 , C07D401/14
CPC分类号: C07D401/12 , C07D213/78 , C07D239/28
摘要: New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译: 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物,组合物和方法。 在某些实施方案中,化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。
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公开(公告)号:US07576221B2
公开(公告)日:2009-08-18
申请号:US11158574
申请日:2005-06-20
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K31/4174 , C07D233/64
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
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公开(公告)号:US20070293491A1
公开(公告)日:2007-12-20
申请号:US11735302
申请日:2007-04-13
申请人: Cynthia Shafer , Annette Walter , Mika Lindvall , Thomas Gesner , Laura Doyle
发明人: Cynthia Shafer , Annette Walter , Mika Lindvall , Thomas Gesner , Laura Doyle
IPC分类号: A61K31/5375 , A61K31/44 , A61K31/445 , A61P35/00 , C07D239/20 , C07D295/00 , C07D241/02 , C07D213/02 , A61K31/496 , A61K31/506
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04
摘要: New compounds capable of acting as CDC7 inhibitors are provided. The compounds are useful either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of CDC7 mediated diseases, such as cancer. The compounds have the Formula (I) or (II), where the values of the variables are defined herein.
摘要翻译: 提供能够作为CDC7抑制剂的新化合物。 该化合物可单独使用或与至少一种其它治疗剂组合用于预防或治疗CDC7介导的疾病例如癌症。 化合物具有式(I)或(II),其中变量的值在本文中定义。
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公开(公告)号:US20070037853A1
公开(公告)日:2007-02-15
申请号:US11502303
申请日:2006-08-09
申请人: Paul Barsanti , Yi Xia , Weibo Wang , Kris Mendenhall , Liana Lagniton , Savithri Ramurthy , Megan Phillips , Sharadha Subramanian , Rustum Boyce , Nathan Brammeier , Ryan Constantine , David Duhl , Annette Walter , Tinya Abrams , Paul Renhowe
发明人: Paul Barsanti , Yi Xia , Weibo Wang , Kris Mendenhall , Liana Lagniton , Savithri Ramurthy , Megan Phillips , Sharadha Subramanian , Rustum Boyce , Nathan Brammeier , Ryan Constantine , David Duhl , Annette Walter , Tinya Abrams , Paul Renhowe
IPC分类号: A61K31/454 , A61K31/4439 , A61K31/42 , A61K31/4178 , A61K31/4172 , C07D413/02 , C07D403/02 , C07D409/02
CPC分类号: C07D401/14 , C07D233/64 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,衍生物的组合物和药学上可接受的载体,以及该化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20060009472A1
公开(公告)日:2006-01-12
申请号:US11158574
申请日:2005-06-20
申请人: Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
发明人: Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/427 , A61K31/4178 , C07D417/02 , C07D43/02
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
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