公开(公告)号：US08375730B2

公开(公告)日：2013-02-19

申请号：US13358662

申请日：2012-01-26

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Eric Paul Mirabel

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Eric Paul Mirabel

IPC: B65B63/08 ,  F25D19/00 ,  F25D3/08

CPC classification number: G06Q10/0832 ,  F25D3/08 ,  F25D3/14 ,  F25D2500/04 ,  G06Q30/012 ,  G06Q50/28

Abstract: Disclosed is a process of selecting of a container and temperature-control system, such that biological products (including blood) requiring maintenance within a specified range of temperatures are so maintained during shipment. The process requires a prediction of the maximum period of shipment, and the predicted ambient temperature ranges and time of exposure thereto for the system during the period of shipment. With that information, a system of container(s) with temperature-control agents including dry ice, ice, frozen gel packs or a phase change material, is selected.

Abstract translation: 公开了一种选择容器和温度控制系统的方法，使得在运输期间维持在特定温度范围内需要维护的生物制品（包括血液）。 该过程需要预测装运期间的最大装运周期，以及预计的环境温度范围和系统暴露于其中的时间。 使用该信息，选择具有包括干冰，冰，冷冻凝胶包或相变材料在内的温度控制剂的容器系统。

公开(公告)号：US20080006628A1

公开(公告)日：2008-01-10

申请号：US11483338

申请日：2006-07-07

Applicant: Michael Goncharko ,  Anthony Alleva

Inventor： Michael Goncharko ,  Anthony Alleva

IPC: B65D6/00

CPC classification number: B65D81/3816

Abstract: Disclosed is a sealed container formed from six rectangular foam insulating panels. The edges of two of the panels forming opposing sides are positioned to face the inner sides of the panels forming the two other opposing sides. The upper side of the bottom panel of the container is positioned to face the lower edges of all the sides. The sides are then strapped together under tension (one or more straps around the outer side of the sides; and, one strap around the edges of each of the two of the opposing sides and the lower surface of the bottom panel, to hold the bottom panel in place). The compressibility of the foam allows the panel edges to compress into the area of the panel sides contacted, thereby bonding the structure firmly together. The cargo is placed inside the container, atop the panel forming the bottom. Alternatively, the bottom panel is not strapped, but the container is placed inside a box, and sealing the box holds the bottom (and top) panels in place. A top panel for the container is positioned in the appropriate place relative to the edges of the side panels, and then fixed into place, optionally with strapping, or otherwise. Generally, the container is placed inside a corrugated box for shipment of cargo.

Abstract translation: 公开了由六个矩形泡沫绝缘板形成的密封容器。 形成相对侧的两个面板的边缘被定位成面对形成两个另外的相对侧面的面板的内侧。 容器的底板的上侧定位成面向所有侧面的下边缘。 然后将侧面张紧在一起（围绕侧面的外侧一个或多个带子）;以及两个相对侧面中的每一个的边缘和底部面板的下表面的一个带子，以将底部 面板就位）。 泡沫的可压缩性允许面板边缘压缩到接触的面板侧面的区域中，从而将结构牢固地结合在一起。 将货物放置在容器内，在面板的顶部形成底部。 或者，底板没有被捆扎，但是容器被放置在箱体内，并且密封箱将底部（和顶部）面板保持在适当的位置。 用于容器的顶部面板相对于侧板的边缘定位在适当的位置，然后固定到位，可选地用带子或其他方式固定。 通常，将容器放置在瓦楞纸箱内装运货物。

公开(公告)号：US20130255847A1

公开(公告)日：2013-10-03

申请号：US13707637

申请日：2012-12-07

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bringas

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bringas

IPC: B29D22/00

CPC classification number: B65B3/04 ,  A01N1/0252 ,  A01N1/0284 ,  B29C65/8238 ,  B29C66/1122 ,  B29C66/242 ,  B29C66/43 ,  B29C66/71 ,  B29D22/003 ,  B29L2031/7148 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y10T156/10 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239 ,  B29K2023/06

Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.

Abstract translation: 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇1.5％肉豆蔻醇和0.5％1-癸醇（熔点约23℃）的包含在密封的柔性聚合物层中的共晶溶液的系统来冷却全血 - 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。

公开(公告)号：US08349552B2

公开(公告)日：2013-01-08

申请号：US13431383

申请日：2012-03-27

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bingas

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bingas

IPC: A01D22/00 ,  F28D15/00 ,  B29D22/00 ,  B29D23/00

CPC classification number: B65B3/04 ,  A01N1/0252 ,  A01N1/0284 ,  B29C65/8238 ,  B29C66/1122 ,  B29C66/242 ,  B29C66/43 ,  B29C66/71 ,  B29D22/003 ,  B29L2031/7148 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y10T156/10 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239 ,  B29K2023/06

Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having, a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.

Abstract translation: 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇，1.5％十四烷醇和0.5％1-癸醇（具有熔点约23℃）的优选共晶溶液的体系，其包含在密封的柔性聚合物层中，用于冷却整个 充血袋 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。

公开(公告)号：US20120266564A1

公开(公告)日：2012-10-25

申请号：US13431383

申请日：2012-03-27

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bingas

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bingas

IPC: B65B3/04

CPC classification number: B65B3/04 ,  A01N1/0252 ,  A01N1/0284 ,  B29C65/8238 ,  B29C66/1122 ,  B29C66/242 ,  B29C66/43 ,  B29C66/71 ,  B29D22/003 ,  B29L2031/7148 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y10T156/10 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239 ,  B29K2023/06

Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% -dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having, a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene

Abstract translation: 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 将包含在密封的柔性聚合物层中的包含98％十一烷醇，1.5％十四烷醇和0.5％1-癸醇（具有约23℃的熔点）的优选共晶溶液的系统用于冷却全血 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分

公开(公告)号：US20120197810A1

公开(公告)日：2012-08-02

申请号：US13358662

申请日：2012-01-26

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Eric P. Mirabel

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Eric P. Mirabel

IPC: G06Q50/28 ,  G06Q10/00

CPC classification number: G06Q10/0832 ,  F25D3/08 ,  F25D3/14 ,  F25D2500/04 ,  G06Q30/012 ,  G06Q50/28

Abstract: Disclosed is a process of selecting of a container and temperature-control system, such that biological products (including blood) requiring maintenance within a specified range of temperatures are so maintained during shipment. The process requires a prediction of the maximum period of shipment, and the predicted ambient temperature ranges and time of exposure thereto for the system during the period of shipment. With that information, a system of container(s) with temperature-control agents including dry ice, ice, frozen gel packs or a phase change material, is selected.

Abstract translation: 公开了一种选择容器和温度控制系统的方法，使得在运输期间维持在指定温度范围内需要维护的生物制品（包括血液）。 该过程需要预测装运期间的最大装运周期，以及预计的环境温度范围和系统暴露于其中的时间。 使用该信息，选择具有包括干冰，冰，冷冻凝胶包或相变材料在内的温度控制剂的容器系统。

公开(公告)号：US08802364B2

公开(公告)日：2014-08-12

申请号：US13707637

申请日：2012-12-07

Applicant: Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bringas

Inventor： Klaus H. Haarmann ,  Anthony Alleva ,  Thomas-Laurent Bringas

IPC: F28D15/00 ,  B29D22/00 ,  B29D23/00

CPC classification number: B65B3/04 ,  A01N1/0252 ,  A01N1/0284 ,  B29C65/8238 ,  B29C66/1122 ,  B29C66/242 ,  B29C66/43 ,  B29C66/71 ,  B29D22/003 ,  B29L2031/7148 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y10T156/10 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239 ,  B29K2023/06

Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.

Abstract translation: 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇1.5％肉豆蔻醇和0.5％1-癸醇（熔点约23℃）的包含在密封的柔性聚合物层中的共晶溶液的系统来冷却全血 - 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。

公开(公告)号：US08192924B1

公开(公告)日：2012-06-05

申请号：US13274593

申请日：2011-10-17

Applicant: Maurice Barakat ,  Louis Thibault ,  Klaus H. Haarmann ,  Annie Beauséjour ,  Anthony Alleva ,  Mario Tremblay ,  Serghe Lapointe

Inventor： Maurice Barakat ,  Louis Thibault ,  Klaus H. Haarmann ,  Annie Beauséjour ,  Anthony Alleva ,  Mario Tremblay ,  Serghe Lapointe

IPC: A01D22/00 ,  F28D15/00 ,  B29D22/00 ,  B29D23/00

CPC classification number: B65B3/04 ,  A01N1/0252 ,  A01N1/0284 ,  B29C65/8238 ,  B29C66/1122 ,  B29C66/242 ,  B29C66/43 ,  B29C66/71 ,  B29D22/003 ,  B29L2031/7148 ,  F28D20/02 ,  F28D2020/0008 ,  Y02E60/145 ,  Y10T156/10 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1393 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239 ,  B29K2023/06

Abstract: A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design used double-layered transparent polyethylene, with two sealed compartments filled with the solution, separated by a flattened and sealed portion between them. One of the two sealed compartments contacts one side of the blood bag and the other compartment is folded over to contact the other side of the blood bag. The transparent compartments allows an operator to verify at any time whether the solution is in a solid state, and the flexibility of the compartments eases the proper positioning of them around a blood bag.

Abstract translation: 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 将包含在密封的柔性聚合物层中的包含98％1-十二烷醇，1.5％十四烷醇和0.5％1-癸醇（熔点约23℃）的优选共晶溶液的系统用于冷却全血 填充袋。 优选的设计是使用双层透明聚乙烯，其中两个密封隔室填充有溶液，它们之间被平坦且密封的部分隔开。 两个密封隔室中的一个接触血袋的一侧，另一个隔室被折叠以接触血袋的另一侧。 透明隔间允许操作者随时验证溶液是否处于固体状态，并且隔室的柔性使其在血袋周围的适当定位变得容易。