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    PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2
    2.
    发明申请
    PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 审中-公开

    公开(公告)号：US20130267513A1

    公开(公告)日：2013-10-10

    申请号：US13697878

    申请日：2011-05-16

    申请人： Brayn Chan ,  Anthony Estrada ,  Zachary Sweeney ,  Edward Giles Mciver ,  Stephen Lewis

    发明人： Brayn Chan ,  Anthony Estrada ,  Zachary Sweeney ,  Edward Giles Mciver ,  Stephen Lewis

    IPC分类号： A61K31/437 ,  A61K31/5377 ,  A61K31/506 ,  C07D471/04

    CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/04 ,  C07D471/04

    摘要： A compound of formula Ia or formula Ib, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; —NHR3; fused aryl-C4-7-heterocycloalkyl; —CONR4R5; —NHCOR6; —C3-7-cycloalkyl; -0-C3-7-cycloalkyl; —NR3R6; and optionally substituted —C1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C1-6-alkyl, C3-7-cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl and halogen, wherein said C1-6-alkyl, Cz-B-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substituted; R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7-cycloalkyl, fused aryl-C-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted; R4 and R5 are each independently hydrogen, or optionally substituted C3-7-cycloalkyl, aryl, heteroaryl, C1-6-alkyl or C3-6-heterocycloalkyl; or R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring; each R6 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each R7 is selected from hydrogen, optionally substituted C1-6-alkyl and C3-7-cycloalkyl; each of R8 and R9 is independently hydrogen or optionally substituted C1-6-alkyl; or R8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl; each R10 is selected from C3-7-cycloalkyl and optionally substituted C1-6-alkyl; each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, —NR4S02R5, —CN, —OR6, —NR4R5, —NR7R11, hydroxyl, —CF3, —CONR4R5, —NR4COR5, —NR7(CO)NR4R5, —N02, —C02H, —C02R6, —S02R6, —S02NR4R5, —NR4COR5, —NR4COOR5, 6-alkyl and —COR6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae Ia and Ib.

    PROPER FREQUENCY PLANNING IN A SYNTHETIC INSTRUMENT RF SYSTEM
    4.
    发明申请
    PROPER FREQUENCY PLANNING IN A SYNTHETIC INSTRUMENT RF SYSTEM 有权
    合成仪器RF系统中的合适频率规划

    公开(公告)号：US20120062302A1

    公开(公告)日：2012-03-15

    申请号：US12879666

    申请日：2010-09-10

    申请人： ANTHONY ESTRADA

    发明人： ANTHONY ESTRADA

    IPC分类号： G06F1/04

    CPC分类号： G06F1/04 ,  H03M1/002 ,  H03M1/0626 ,  H03M1/1255

    摘要： A system and method for clocking in analog-to-digital (ADC) converter in a synthetic instrument unit is presented. A method begins by applying an input clock to an amplifier to produce an amplified clock. The amplified clock is filtered to produce a filtered clock. The ADC of this synthetic instrument unit is clocked with the filtered clock. The input frequency of the ADC corresponds to a second or higher order Nyquist zone that is above the sampling frequency of the ADC. The input data is carried by an intermediate frequency (IF) signal. The filtered clock of ADC is switched off a clock path of the ADC when the ADC is not in use.

    摘要翻译： 提出了一种用于在合成仪器单元中对模数（ADC）转换器进行计时的系统和方法。 一种方法是通过向放大器施加输入时钟以产生放大的时钟。 放大的时钟被滤波以产生滤波时钟。 该合成仪器单元的ADC由滤波时钟计时。 ADC的输入频率对应于高于ADC采样频率的第二或更高阶奈奎​​斯特区。 输入数据由中频（IF）信号承载。 当ADC不使用时，ADC的滤波时钟将关闭ADC的时钟路径。

    Short pulse automatic ranging anti-ship missile fuze
    5.
    发明授权
    Short pulse automatic ranging anti-ship missile fuze 失效
    短脉冲自动测距反舰导弹引信

    公开(公告)号：US06617998B1

    公开(公告)日：2003-09-09

    申请号：US05069516

    申请日：1970-08-06

    申请人： Richard D. Cook ,  Bennie D. Macomber ,  William F. Vizard ,  Eldridge A. Williamson ,  Anthony Estrada

    发明人： Richard D. Cook ,  Bennie D. Macomber ,  William F. Vizard ,  Eldridge A. Williamson ,  Anthony Estrada

    IPC分类号： G01S740

    CPC分类号： F42C13/02 ,  G01S13/16

    摘要： An active short pulse fuze system for arming on a true target acquisition and firing only on the loss of the acquired target signal. The sea surface is tracked by means of a sea tracking loop A target threshold is established and is coupled to the sea tracking loop so as to expand and contract with the sea tracking. A return signal will pass the target threshold only when there is an abrupt reduction in range, indicating the presence of a target. The presence of this signal will arm the firing circuit. An abrupt increase in range will indicate the loss of the target and cause immediate detonation of the warhead.

    摘要翻译： 一个主动的短脉冲引信系统，用于对仅在获得的目标信号的损失上的真实目标采集和点火进行布防。 通过海上跟踪循环来跟踪海面。建立目标阈值，并将其耦合到海上跟踪循环，以便与海上跟踪扩大和收缩。 只有当范围突然减小时，返回信号才会通过目标阈值，表明存在目标。 该信号的存在将使发射电路臂臂。 范围突然增加将表明目标的损失并导致弹头的立即爆炸。