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公开(公告)号：US20100183212A1
公开(公告)日：2010-07-22
申请号：US12684816
申请日：2010-01-08
IPC分类号： G06K9/00
摘要： The present invention relates in general to compositions, processes and apparatus for imaging, and in particular for improved preparation, collection and processing of images of specimens that include cartilage, particularly specimens of intact or disarticulated joints. Images of specimens according to the present invention include images obtained from X-ray microscopic computed tomography.
摘要翻译： 本发明一般涉及用于成像的组合物，方法和装置，特别是用于改进包括软骨，特别是完整或脱节关节的标本的样品的图像的制备，收集和加工的改进的组合物，方法和装置。 根据本发明的样本的图像包括从X射线显微镜计算机断层摄影获得的图像。
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2.发明授权
公开(公告)号：US5919702A
公开(公告)日：1999-07-06
申请号：US735620
申请日：1996-10-23
IPC分类号： C12N15/09 , A61K35/12 , A61K35/32 , A61K38/00 , A61L27/38 , A61P17/00 , A61P19/00 , C12N5/02 , C12N5/077 , C12N5/10 , C12N15/08 , C12N15/85 , C12P21/02 , C12Q1/00 , C12N5/00 , A01N63/00
CPC分类号： A61L27/3817 , A61L27/3633 , A61L27/3654 , A61L27/3852 , A61L27/3895 , C12N15/85 , C12N5/0655 , A61K35/12 , A61K38/00 , C12N2500/38 , C12N2501/15
摘要： The invention relates to the isolation and use of pre-chondrocytes from the umbilical cord, specifically from Wharton's jelly, that give rise to chondrocytes which produce cartilage. The isolated pre-chondrocytes, or the chondrocytes to which they give rise, can be mitotically expanded in culture and used in the production of new cartilage tissue for therapeutic use. "Banks" of pre-chondrocytes or chondrocytes can be stored frozen, and thawed and used to produce new cartilage tissue as needed.
摘要翻译： 本发明涉及分离和使用来自脐带的软骨细胞，特别是沃顿的果冻，其产生产生软骨的软骨细胞。 分离的软骨细胞或其产生的软骨细胞可以在培养物中有丝分裂扩增，并用于生产用于治疗用途的新软骨组织。 软骨细胞或软骨细胞的“银行”可以冷冻储藏，并根据需要解冻并用于生产新的软骨组织。
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公开(公告)号：US5597578A
公开(公告)日：1997-01-28
申请号：US234509
申请日：1994-04-28
IPC分类号： A61K31/135 , A61K9/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61K47/42 , A61K47/48 , A61P35/00 , C07K14/00 , C07K14/435 , C07K14/495 , C07K14/52 , C07K17/04 , A61K9/10 , A61K38/39
CPC分类号： A61K9/0024 , A61K38/1841 , A61K47/42 , A61K47/48269
摘要： Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-.beta., at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of the target cell, particularly when used in combination with a vasoconstrictive agent.
摘要翻译： 提供抗增殖组合物，其能够在靶细胞附近的部位持续释放抗增殖剂，特别是TGF-β。 所述组合物有效抑制靶细胞的增殖，特别是当与血管收缩剂组合使用时。
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4.发明授权
公开(公告)号：US5244793A
公开(公告)日：1993-09-14
申请号：US667246
申请日：1991-03-08
申请人： Anthony F. Purchio , Linda Madisen
发明人： Anthony F. Purchio , Linda Madisen
IPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/495 , C07K14/52 , C07K19/00 , C12N15/16 , C12R1/91
CPC分类号： C07K14/495 , A61K38/00 , C07K2319/00 , C07K2319/75
摘要： A chimeric transforming growth factor-beta termed TGF-.beta.1/.beta.2, a DNA molecule encoding TGF-.beta.1/.beta.2, a mammaliam cell transformed with said DNA molecule, and a method for producing chimeric TGF-.beta.1/.beta.2 are disclosed.
摘要翻译： 称为TGF-β1/β2的嵌合转化生长因子-β，编码TGF-β1/β2的DNA分子，用所述DNA分子转化的哺乳动物细胞，以及用于产生嵌合TGF-β1/β2的方法 被披露。
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公开(公告)号：US20120246745A1
公开(公告)日：2012-09-27
申请号：US13489612
申请日：2012-06-06
申请人： Anthony F. PURCHIO
发明人： Anthony F. PURCHIO
CPC分类号： G01N33/5014 , A01K2267/0393 , G01N33/5088
摘要： The present invention provides an animal toxicity model that can be used to screen agents that may cause or increase the occurrence of a developmental defect. The invention also provides methods and compositions for creating such an animal toxicity model, as well as methods and kits for using these animal models.
摘要翻译： 本发明提供了可用于筛选可能引起或增加发育缺陷的发生的药剂的动物毒性模型。 本发明还提供了用于产生这种动物毒性模型的方法和组合物，以及用于使用这些动物模型的方法和试剂盒。
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公开(公告)号：US20100172463A1
公开(公告)日：2010-07-08
申请号：US12684793
申请日：2010-01-08
申请人： Anthony F. Purchio
发明人： Anthony F. Purchio
IPC分类号： G01N23/00
摘要： The present invention relates in general to compositions, processes and apparatus for imaging, and in particular for preparation, collection and processing of images of atherosclerotic plaques, including images obtained from X-ray microscopic computed tomography.
摘要翻译： 本发明一般涉及用于成像，特别是用于制备，收集和处理动脉粥样硬化斑块的组合物，方法和装置，包括从X射线显微镜计算机断层摄影获得的图像。
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公开(公告)号：US6027935A
公开(公告)日：2000-02-22
申请号：US660347
申请日：1996-06-05
申请人： Anthony F. Purchio , Liguo New , Kang Liu , Vafa Kamali , Brian Naughton
发明人： Anthony F. Purchio , Liguo New , Kang Liu , Vafa Kamali , Brian Naughton
IPC分类号： C12N15/09 , A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , C07K14/475 , C07K14/81 , C12N5/10 , C12P21/08 , C12Q1/68 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/475 , C07K14/8121 , A61K38/00
摘要： The novel gene, Rasp-1, which is up-regulated in regenerating liver, is disclosed. The novel RASP-1 protein, which is encoded by the Rasp-1 gene, is also disclosed. In addition, antibodies against the Rasp-1 gene products are also disclosed. Furthermore, the use of Rasp-1 nucleic acid sequences, Rasp-1 gene products, and antibodies against Rasp-1 gene products in the treatment and diagnosis of liver disorders is also disclosed.
摘要翻译： 公开了在再生肝中上调的新基因Rasp-1。 还公开了由Rasp-1基因编码的新型RASP-1蛋白。 此外，还公开了针对Rasp-1基因产物的抗体。 此外，还公开了Rasp-1核酸序列，Rasp-1基因产物和针对Rasp-1基因产物的抗体在肝脏疾病的治疗和诊断中的用途。
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公开(公告)号：US5444164A
公开(公告)日：1995-08-22
申请号：US878960
申请日：1992-05-04
IPC分类号： C12N15/09 , C07K14/00 , C07K14/47 , C07K14/495 , C07K14/52 , C07K14/71 , C07K16/00 , C12N15/12 , C12P21/02 , C12R1/91 , C07H15/12
CPC分类号： C07K14/71
摘要： A new TGF-.beta. induced gene and protein is described. Treatment of TGF-.beta. growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF-.beta., and is shown to inhibit the growth of tumor cells.
摘要翻译： 描述了一种新的TGF-β诱导的基因和蛋白质。 TGF-β生长停滞细胞的治疗诱导产生一种新的基因，其编码含有四个同源重复区并且可以代表细胞表面识别分子的称为BIG-H3的683氨基酸蛋白。 在用TGF-β处理后，该哺乳动物细胞，特别是人细胞中诱导该基因和蛋白质，并且显示其抑制肿瘤细胞的生长。
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公开(公告)号：US5714588A
公开(公告)日：1998-02-03
申请号：US791584
申请日：1997-01-31
IPC分类号： C12N15/09 , A61K9/00 , A61K9/70 , A61K38/00 , A61K47/42 , A61K48/00 , A61L15/32 , A61L27/60 , A61P17/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/78 , C12N5/00 , C12N5/10 , C12N15/12 , C12P21/02 , A61K38/18 , C07K17/08
CPC分类号： A61L27/60 , A61L15/32 , C07K14/4705 , C07K14/78 , C12N5/0068 , A61K38/00 , C12N2533/50 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/944 , Y10S514/945 , Y10S514/946 , Y10S514/947
摘要： A method of producing recombinant transforming growth factor .beta.-induced H3 protein and the use of this protein to accelerate wound healing. H3 promoted adhesion of human dermal fibroblasts to tissue culture plastic. The protein is applied directly to a wound or is used to promote adhesion and spreading of dermal fibroblasts to a solid support such as a nylon mesh which is then applied to the wound. In addition, CHO cells expressing H3 inhibited tumor cell growth.
摘要翻译： 一种产生重组转化生长因子β诱导的H3蛋白的方法，以及使用该蛋白加速伤口愈合。 H3促进人类真皮成纤维细胞对组织培养塑料的粘附。 将蛋白质直接施加到伤口上，或者用于促进真皮成纤维细胞的粘附和铺展到诸如尼龙网的固体支持物上，然后将其施加到伤口上。 此外，表达H3的CHO细胞抑制肿瘤细胞生长。
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公开(公告)号：US5618715A
公开(公告)日：1997-04-08
申请号：US75199
申请日：1993-06-10
申请人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
发明人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
IPC分类号： A61K38/00 , C07K14/07 , C07K14/475 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24 , C12N15/62 , C12N15/73 , C12N5/00 , C07H17/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/191 , A61K38/204 , C07K14/475 , C07K14/495 , C07K14/52 , C07K14/522 , C07K16/22 , C07K16/24 , C12N15/625 , C12N15/73 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2710/24122
摘要： Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
摘要翻译： 提供了包含制瘤素M及其同源物的新型组合物，以及其制备方法及其使用方法。 组合物可以通过从天然来源或通过重组方法在原核或真核宿主细胞中分离来制备。 此外，公开了制瘤素M的DNA和多肽序列。 该组合物可用于调节细胞的生长，特别是抑制肿瘤细胞增殖，刺激正常的细胞生长，特别是涉及造血的细胞。 细胞生长抑制组合物可另外包括包含转化生长因子，肿瘤坏死因子或干扰素中的至少一种的辅助剂。 对制瘤素M具有高亲和力的受体可以另外用于筛选多肽用于制瘤素M样活性。 还提供了使用针对制瘤素M mRNA特异性的组合物和探针的抗体作为肿瘤细胞检测手段的方法。
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