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    SURGICAL STAPLER
    1.
    发明申请
    SURGICAL STAPLER 审中-公开
    外科手术

    公开(公告)号：US20160074033A1

    公开(公告)日：2016-03-17

    申请号：US14783793

    申请日：2014-04-08

    申请人： Antonio LONGO

    发明人： Federico BILOTTI

    IPC分类号： A61B17/068 ,  A61B17/10

    CPC分类号： A61B17/068 ,  A61B17/105 ,  A61B17/1155 ,  A61B2017/07257

    摘要： An anvil assembly is described. The anvil assembly includes including an axis with a proximal and a distal portion, an anvil associated to the distal portion of the axis formed by a central portion and at least a remote rotating portion and a system for reducing the encumbrance of the assembly of the anvil and relative restoring of such encumbrance. This is possible thanks to a half-automatic system specifically activated by the user of the surgical instrument and/or by an automatic system integrated in the system for opening and closing the surgical instrument without the need of activating any specific mechanism. The reduction and the restoring of the anvil size is an advantage during the insertion and the removal of the anvil into and from the organ of the patient.

    摘要翻译： 描述了砧座组件。 所述砧座组件包括包括具有近侧和远侧部分的轴线，与所述轴线的远端部分相关联的砧座，所述远端部分由中心部分和至少一个远程旋转部分形成，并且所述系统用于减小所述砧座组件的阻碍 并相对恢复这种负担。 这是由于由外科器械的用户专门激活的半自动系统和/或通过集成在系统中的自动系统来打开和关闭外科器械而不需要激活任何特定的机构。 在将砧座插入和移出患者的器官期间，砧座尺寸的减小和恢复是有利的。

    Diagnostic device for tubular anatomical structures
    2.
    发明授权
    Diagnostic device for tubular anatomical structures 有权
    用于管状解剖结构的诊断装置

    公开(公告)号：US09173546B2

    公开(公告)日：2015-11-03

    申请号：US10579014

    申请日：2004-11-16

    申请人： Jesse J. Kuhns ,  Michele D'Arcangelo ,  Federico Bilotti ,  Antonio Longo

    发明人： Jesse J. Kuhns ,  Michele D'Arcangelo ,  Federico Bilotti ,  Antonio Longo

    IPC分类号： A61M29/00 ,  A61B1/00 ,  A61B1/31 ,  A61B1/32

    CPC分类号： A61B1/00085 ,  A61B1/00087 ,  A61B1/31 ,  A61B1/32

    摘要： A diagnostic device (10) for pathologies of tubular anatomical structures comprises a tubular elongated structure (12, 28) developing between a proximal end and a distal end and is adapted to be inserted in the tubular anatomical structure, means (22) for locally dilating the walls of the tubular anatomical structure being associated with the distal end of said elongated structure, said means for locally dilating being movable between a closed position for introducing the device and at least one open position for viewing and evaluating the pathology, and control means being associated with the proximal end of the elongated structure, said control means being operatively connected to said means for locally dilating, in order to move them between the closed position and the open position, and vice versa.

    摘要翻译： 用于管状解剖结构病理的诊断装置（10）包括在近端和远端之间形成的管状细长结构（12,28），并适于插入管状解剖结构中，用于局部扩张的装置（22） 所述管状解剖结构的壁与所述细长结构的远端相关联，所述用于局部扩张的装置可在用于引入装置的关闭位置和用于观察和评估病理的至少一个打开位置之间移动，以及控制装置 与所述细长结构的近端相关联，所述控制装置可操作地连接到所述用于局部扩张的装置，以便在关闭位置和打开位置之间移动它们，反之亦然。

    Diagnostic device for tubular anatomical structures
    4.
    发明申请
    Diagnostic device for tubular anatomical structures 有权
    用于管状解剖结构的诊断装置

    公开(公告)号：US20070149845A1

    公开(公告)日：2007-06-28

    申请号：US10579014

    申请日：2004-11-16

    申请人： Jesse Kuhns ,  Michele D'Arcangelo ,  Federico Bilotti ,  Antonio Longo

    发明人： Jesse Kuhns ,  Michele D'Arcangelo ,  Federico Bilotti ,  Antonio Longo

    IPC分类号： A61B1/00

    CPC分类号： A61B1/00085 ,  A61B1/00087 ,  A61B1/31 ,  A61B1/32

    摘要： A diagnostic device (10) for pathologies of tubular anatomical structures comprises a tubular elongated structure (12, 28) developing between a proximal end and a distal end and is adapted to be inserted in the tubular anatomical structure, means (22) for locally dilating the walls of the tubular anatomical structure being associated with the distal end of said elongated structure, said means for locally dilating being movable between a closed position for introducing the device and at least one open position for viewing and evaluating the pathology, and control means being associated with the proximal end of the elongated structure, said control means being operatively connected to said means for locally dilating, in order to move them between the closed position and the open position, and vice versa.

    摘要翻译： 用于管状解剖结构病理的诊断装置（10）包括在近端和远端之间形成的管状细长结构（12,28），并适于插入管状解剖结构中，用于局部扩张的装置（22） 管状解剖结构的壁与所述细长结构的远端相关联，所述用于局部扩张的装置可在用于引入装置的关闭位置和用于观察和评估病理的至少一个打开位置之间移动，以及控制装置 与所述细长结构的近端相关联，所述控制装置可操作地连接到所述用于局部扩张的装置，以便在关闭位置和打开位置之间移动它们，反之亦然。

    Surgical stapling instrument
    5.
    发明授权
    Surgical stapling instrument 有权

    公开(公告)号：US06805273B2

    公开(公告)日：2004-10-19

    申请号：US10287066

    申请日：2002-11-04

    申请人： Federico Bilotti ,  Antonio Longo

    发明人： Federico Bilotti ,  Antonio Longo

    IPC分类号： A61B17072

    CPC分类号： A61B17/1114 ,  A61B17/072 ,  A61B17/115 ,  A61B17/1155 ,  A61B2017/07221

    摘要： A surgical stapling instrument (1) comprises a body portion (2, 3), a handle (4) and a staple fastening assembly (8). The staple fastening assembly (8) includes a curved cartridge (10), which comprises at least one curved open row of staples, and a curved anvil (22), which is adapted to cooperate with the cartridge (10) for forming the ends of the staples exiting from the cartridge (10). The staple fastening assembly (8) is adapted to allow unobstructed access towards the concave inner faces of the cartridge (10) and the anvil (22). The cartridge (10) can be moved towards the anvil (22) from a spaced position for positioning tissue therebetween to a closed position for clamping the tissue. Preferably, a knife is contained within the cartridge (10) and is positioned such that there is at least one row of staples on at least one side of the knife.

    Anoscope for hemorrhoidal surgery
    7.
    发明授权
    Anoscope for hemorrhoidal surgery 有权
    痔疮手术

    公开(公告)号：US6142933A

    公开(公告)日：2000-11-07

    申请号：US197836

    申请日：1998-11-23

    申请人： Antonio Longo ,  John R. Bittner ,  Randall L. Hacker

    发明人： Antonio Longo ,  John R. Bittner ,  Randall L. Hacker

    IPC分类号： A61B17/11 ,  A61B17/115 ,  A61B1/00

    CPC分类号： A61B1/31 ,  A61B17/115 ,  A61B17/1155 ,  A61B2017/1142

    摘要： An anoscope adapted for the suturing of hemorrhoids during a hemorrhoid removal procedure is disclosed. The anoscope has a distal conical tip, a channel body extending proximally from the distal conical tip and a flange radiused outwardly from the channel. A slot is formed in the channel body and runs longitudinally from the distal conical tip through the flange and is flanked by a pair of mutually opposed finger wings that extend out from the flange. The finger wings each have a distal finger wing tip and a concave surface embedded within the finger wing tips. The concave surfaces are sized for the placement of a finger of a user therein.

    摘要翻译： 公开了一种适用于在痔疮切除手术期间缝合痔疮的眼镜。 眼镜具有远端锥形尖端，从远端锥形末端向近侧延伸的通道体和从通道向外方向凸出的凸缘。 狭槽形成在通道主体中，并且从远端锥形末端通过凸缘纵向延伸，并且由一对彼此相对的指状翼片侧翼，该对翼指从翼缘延伸出来。 手指翼各自具有远端指尖翼尖和嵌入在手指翼尖内的凹面。 凹表面的尺寸用于将用户的手指放置在其中。

    Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
    8.
    发明授权
    Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation 失效
    取代的3-亚芳基-7-氮杂羟基吲哚化合物及其制备方法

    公开(公告)号：US5719135A

    公开(公告)日：1998-02-17

    申请号：US669315

    申请日：1996-07-09

    申请人： Franco Buzzetti ,  Gabriella Maria Brasca ,  Antonio Longo ,  Dario Ballinari

    发明人： Franco Buzzetti ,  Gabriella Maria Brasca ,  Antonio Longo ,  Dario Ballinari

    IPC分类号： A61K31/435 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  C07D519/00 ,  A61K31/675 ,  A61K31/44 ,  C07D401/00 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present invention relates to compound of formula (I) ##STR1## wherein A is benzene, naphthalene, 5,6,7,8,-tetrahydronaphthalene, quinoline, isoquinoline, indole or 7-azaindole; R.sub.1 is --H, --CN, --SO.sub.3 R.sub.4 --, --SO.sub.2 NHR.sub.5, ##STR2## --COOR.sub.6, --CONHCH.sub.2 (CHOH).sub.n CH.sub.2 OH, ##STR3## --NR.sub.7 R.sub.8, --N(CH.sub.2 CH.sub.2 OH).sub.2, --NHCH.sub.2 (CHOH).sub.n CH.sub.2 OH, --NHCONH.sub.2, --NH--C(NH.sub.2).dbd.NH, --NHCO(CHOH).sub.n CH.sub.2 OH, ##STR4## --NHSO.sub.2 R.sub.9, --OR.sub.10, --OCH.sub.2 (CHOH).sub.n CH.sub.2 OH, --OOC(CHOH).sub.n CH.sub.2 OH, --OPO(OH).sub.2, --CH.sub.2 NH.sub.2, --C(NH.sub.2).dbd.NH, --CH.sub.2 NHC(NH.sub.2).dbd.NH, ##STR5## --CH.sub.2 OH, --CH.sub.2 OOC(CHOH).sub.n CH.sub.2 OH, --CH.sub.2 OPO(OH).sub.2 or --PO(OH).sub.2 ; R.sub.2 is C.sub.1 -C.sub.6 alkyl, halogen, or hydroxy; R.sub.3 is --H or C.sub.1 -C.sub.6 alkyl; R.sub.4 is --H, C.sub.1 -C.sub.6 alkyl or --CH.sub.2 (CHOH).sub.n CH.sub.2 OH; R.sub.5 is --H, C.sub.1 -C.sub.6 alkyl, --CH.sub.2 (CHOH).sub.n CH.sub.2 OH or --(CH.sub.2).sub.m NMe.sub.2 ; R.sub.6 is --H, C.sub.1 -C.sub.6 alkyl or --CH.sub.2 (CHOH).sub.n CH.sub.2 OH; each of R.sub.7 and R.sub.8 independently is --H or C.sub.1 -C.sub.6 alkyl;R.sub.9 is methyl or tolyl; R.sub.10 is --H, C.sub.1 -C.sub.6 alkyl, or C.sub.2 -C.sub.6 alkanoyl; Z is >CH.sub.2, >O, >NH, or >NCH.sub.2 CH.sub.2 OH; n is zero or 1; m is 2 or 3; p is 1, 2 or 3; q is zero, 1 or 2; and the pharmaceutically acceptable salt thereof, for use as tyrosine kinase inhibitors.

    摘要翻译： PCT No.PCT / EP95 / 04247 Sec。 371日期：1996年7月9日 102（e）日期1996年7月9日PCT提交1995年10月30日PCT公布。 公开号WO96 / 16964 日本时间1996年6月6日本发明涉及式（I）化合物其中A为苯，萘，5,6,7,8， - 四氢萘，喹啉，异喹啉，吲哚或7-氮杂吲哚; R1是-H，-CN，-SO3R4-，-SO2NHR5，-COOR6，-CONHCH2（CHOH）nCH2OH，图示-NR7R8，-N（CH2CH2OH）2，-NHCH2（CHOH）nCH2OH，-NHCONH2 ，-NH-C（NH 2）= NH，-NHCO（CHOH）n CH 2 OH，-NCO 2 -NH 9，-OR 10，-OCH 2（CHOH）n CH 2 OH，-OOC（CHOH）n CH 2 OH，-OPO（OH）2，-CH 2 NH ，-C（NH 2）= NH，-CH 2 NHC（NH 2）= NH，-CH 2 OH，-CH 2 OOC（CHOH）n CH 2 OH，-CH 2 OPO（OH）2或-PO（OH） R2是C1-C6烷基，卤素或羟基; R3是-H或C1-C6烷基; R4是-H，C1-C6烷基或-CH2（CHOH）nCH2OH; R5是-H，C1-C6烷基，-CH2（CHOH）nCH2OH或 - （CH2）mNMe2; R6是-H，C1-C6烷基或-CH2（CHOH）nCH2OH; R 7和R 8各自独立地为-H或C 1 -C 6烷基; R9为甲基或甲苯基; R 10是-H，C 1 -C 6烷基或C 2 -C 6烷酰基; Z是> CH2，> O，> NH或> NCH2CH2OH; n为零或1; m为2或3; p为1,2或3; q为零，1或2; 及其药学上可接受的盐，用作酪氨酸激酶抑制剂。