专利检索 ap:"Aregahegn Yifru" 第 1 页

1.

发明授权
Organic compounds and their uses 有权
标题翻译：有机化合物及其用途

公开(公告)号：US08445527B2

公开(公告)日：2013-05-21

申请号：US13477866

申请日：2012-05-22

申请人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic

发明人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic

IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403

CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016

摘要： The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or stereoisomers thereof.

摘要翻译： 本发明提供了通过给予式I化合物或其药学上可接受的盐或其立体异构体来治疗有需要的受试者的HCV感染的方法。

2.

发明申请
Organic Compounds and Their Uses 有权
标题翻译：有机化合物及其用途

公开(公告)号：US20090137495A1

公开(公告)日：2009-05-28

申请号：US12249186

申请日：2008-10-10

申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng

发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng

IPC分类号： A61K38/07 , C07K5/113 , C07D498/04 , C07D207/08 , A61P31/12

CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016

摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。

3.

发明申请
Pegylated Ion Channel Modulating Compounds 有权
标题翻译：聚乙二醇化离子通道调节化合物

公开(公告)号：US20080021005A1

公开(公告)日：2008-01-24

申请号：US11547419

申请日：2005-03-31

申请人： Elizabeth Cheu , Lewis Choi , Doug Chou , Allen Davidoff , Alan Ezrin , Grace Jung , Bertrand Plouvier , Aregahegn Yifru

发明人： Elizabeth Cheu , Lewis Choi , Doug Chou , Allen Davidoff , Alan Ezrin , Grace Jung , Bertrand Plouvier , Aregahegn Yifru

IPC分类号： C07D207/12 , A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/427 , A61K31/4439 , A61K31/497 , C07D277/20 , C07D401/02 , C07D487/02 , C07D487/00 , C07D403/14 , C07D403/02 , C07D401/04 , C07D281/00 , C07D209/82 , A61K31/501 , A61K31/519 , A61K31/55 , A61K31/58 , A61P9/00

CPC分类号： C07H15/203 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07D209/94 , C07F9/572

摘要： This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed

摘要翻译： 本发明涉及某些离子通道调节化合物的PEG衍生物，药物偶联物和同位素衍生物。还公开了药物组合物和使用方法

4.

发明申请
CYCLIC PEPTIDES AND USE AS MEDICINES 审中-公开
标题翻译：循环肽和用作药物

公开(公告)号：US20150306172A1

公开(公告)日：2015-10-29

申请号：US14717872

申请日：2015-05-20

申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru

发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru

IPC分类号： A61K38/13 , A61K45/06 , C07K7/64

CPC分类号： A61K38/13 , A61K38/12 , A61K45/06 , C07K7/64 , C07K7/645 , A61K2300/00

摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。

5.

发明申请
MONOBACTAM ORGANIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权
标题翻译：用于治疗细菌感染的单加生物有机化合物

公开(公告)号：US20150266867A1

公开(公告)日：2015-09-24

申请号：US14665245

申请日：2015-03-23

申请人： Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU

发明人： Virender Singh AULAKH , Anthony CASAREZ , Xiaodong LIN , Mika LINDVALL , Glenn MCENROE , Heinz Ernst MOSER , Folkert RECK , Meiliana TJANDRA , Robert Lowell SIMMONS , Aregahegn YIFRU , Qingming ZHU

IPC分类号： C07D417/14 , A61K31/454 , A61K31/4439 , A61K45/06 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K31/427 , A61K31/433

CPC分类号： A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481

摘要： This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

摘要翻译： 本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。在某些方面，本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。

6.

发明授权
Cyclic peptides and use as medicines 有权
标题翻译：循环肽并用作药物

公开(公告)号：US09072696B2

公开(公告)日：2015-07-07

申请号：US14037644

申请日：2013-09-26

申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru

发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru

IPC分类号： A61K38/12 , C07K7/64 , A61K45/06

CPC分类号： A61K38/13 , A61K38/12 , A61K45/06 , C07K7/64 , C07K7/645 , A61K2300/00

摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。

7.

发明授权
Organic compounds and their uses 失效
标题翻译：有机化合物及其用途

公开(公告)号：US08222425B2

公开(公告)日：2012-07-17

申请号：US13185683

申请日：2011-07-19

申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng

发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng

IPC分类号： C07D207/00

CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016

摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。

8.

发明授权
Monobactam organic compounds for the treatment of bacterial infections 有权
标题翻译：单链有机化合物用于治疗细菌感染

公开(公告)号：US09174978B2

公开(公告)日：2015-11-03

申请号：US14665245

申请日：2015-03-23

申请人： Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu

发明人： Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu

IPC分类号： A61K31/40 , C07D417/14 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K45/06

CPC分类号： A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481

摘要： This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

摘要翻译： 本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。在某些方面，本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。