公开(公告)号：US20160160385A1

公开(公告)日：2016-06-09

申请号：US14306941

申请日：2014-06-17

Applicant: Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

Inventor： Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

IPC: C30B23/00 ,  C30B29/48 ,  C30B29/66 ,  C30B23/02

CPC classification number: C30B23/005 ,  C30B23/02 ,  C30B23/025 ,  C30B29/48 ,  C30B29/66 ,  Y10T117/10 ,  Y10T117/1004

Abstract: The present invention relates to an apparatus for vapour phase crystal growth to produce multiple single crystals in one growth cycle comprising one central source chamber, a plurality of growth chambers, a plurality of passage means adapted for transport of vapour from the source chamber to the growth chambers, wherein the source chamber is thermally decoupled from the growth chambers.

Abstract translation: 本发明涉及用于在一个生长循环中产生多个单晶的气相晶体生长的装置，包括一个中心源室，多个生长室，适于将蒸气从源室输送到生长的多个通道装置 室，其中源室与生长室热分离。

公开(公告)号：US20130331456A1

公开(公告)日：2013-12-12

申请号：US13821682

申请日：2011-09-13

Applicant: Arnab Basu ,  Debra M. Mills ,  John D. Williams ,  Bing Li ,  Norton P. Peet ,  Terry L. Bowlin

Inventor： Arnab Basu ,  Debra M. Mills ,  John D. Williams ,  Bing Li ,  Norton P. Peet ,  Terry L. Bowlin

IPC: C07C311/44

CPC classification number: C07C311/44 ,  A61K31/18

Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

公开(公告)号：US08093095B2

公开(公告)日：2012-01-10

申请号：US12158111

申请日：2006-12-21

Applicant: Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

Inventor： Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

IPC: H01L21/00

CPC classification number: H01L31/115 ,  H01L31/1828 ,  Y02E10/543

Abstract: Device and method of forming a device in which a substrate (10) is fabricated with at least part of an electronic circuit for processing signals. A bulk single crystal material (14) is formed on the substrate, either directly on the substrate (10) or with an intervening thin film layer or transition region (12). A particular application of the device is for a radiation detector.

公开(公告)号：US20100327277A1

公开(公告)日：2010-12-30

申请号：US12880458

申请日：2010-09-13

Applicant: Arnab Basu ,  Max Robinson ,  Benjamin John Cantwell ,  Andy Brinkman

Inventor： Arnab Basu ,  Max Robinson ,  Benjamin John Cantwell ,  Andy Brinkman

IPC: H01L31/0296

CPC classification number: H01L31/115 ,  H01L31/1828 ,  Y02E10/543

Abstract: Device and method of forming a device in which a substrate (10) is fabricated with at least part of an electronic circuit for processing signals. A bulk single crystal material (14) is formed on the substrate, either directly on the substrate (10) or with an intervening thin film layer or transition region (12). A particular application of the device is for a radiation detector.

Abstract translation: 制造其中用至少部分用于处理信号的电子电路的衬底（10）制造的器件的装置和方法。 在衬底上，直接在衬底（10）上或与中间的薄膜层或过渡区（12）形成体积单晶材料（14）。 该设备的特定应用是用于辐射检测器。

公开(公告)号：US20100139555A1

公开(公告)日：2010-06-10

申请号：US12598538

申请日：2008-05-16

Applicant: Arnab Basu ,  Ben Cantwell ,  Max Robinson

Inventor： Arnab Basu ,  Ben Cantwell ,  Max Robinson

IPC: G01J5/00 ,  C30B23/00 ,  C30B23/06

CPC classification number: C30B23/06 ,  C23C16/42 ,  C23C16/46 ,  C30B25/10 ,  C30B29/48 ,  C30B35/002 ,  Y10T117/10

Abstract: Apparatus for vapour phase growing of crystals having a single multi-zone heater arranged to heat a heated zone to give a predetermined temperature profile along the length of the heated zone. A generally U-shaped tube having a first limb, a second limb, and a linkage connecting the first and second limbs is located on the heated zone. The first limb contains a source material. The second limb supports a seed such that the source material and seed are spaced longitudinally within the heated zone to provide a predetermined temperature differential between the source and seed. The crystal is grown on the seed.

Abstract translation: 用于气相生长具有单个多区加热器的晶体的装置，其布置成加热加热区以沿着加热区的长度给出预定的温度分布。 具有第一肢体，第二肢体和连接第一和第二肢体的连杆的大致U形管位于加热区域上。 第一肢含有源材料。 第二肢支撑种子，使得源材料和种子在加热区域内纵向隔开，以在源和种子之间提供预定的温差。 晶体生长在种子上。

公开(公告)号：US20080081044A1

公开(公告)日：2008-04-03

申请号：US11506161

申请日：2006-08-17

Applicant: Ratna Ray ,  Ranjit Ray ,  Arnab Basu ,  Tatsuo Kanda

Inventor： Ratna Ray ,  Ranjit Ray ,  Arnab Basu ,  Tatsuo Kanda

IPC: A61K39/29 ,  C12N5/08 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K2039/525 ,  C12N2770/24251 ,  C12Q1/18 ,  G01N33/5067 ,  G01N2333/18

Abstract: The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77) transfected immortal human hepatocyte (IHH) capable of generating infectious HCV 1a virus particles in culture. Also disclosed are methods of using the cell line, or HCV 1a virus particles derived from said cell line, to screen for potential therapeutic agents which interfere with HCV 1a virus propagation to treat hepatic disease.

Abstract translation: 本发明提供了一种在培养中能够产生感染性丙型肝炎病毒1a（HCV1a）颗粒的细胞系。 公开了能够在培养中产生感染性HCV 1a病毒颗粒的HCV 1a（克隆H77）转染的永生人肝细胞（IHH）的组合物和方法。 还公开了使用细胞系或源自所述细胞系的HCV 1a病毒颗粒筛选干扰HCV 1a病毒繁殖以治疗肝脏疾病的潜在治疗剂的方法。

公开(公告)号：US20060275838A1

公开(公告)日：2006-12-07

申请号：US11436384

申请日：2006-05-18

Applicant: Ranjit Ray ,  Ratna Ray ,  Arnab Basu ,  Yie-Hwa Chang

Inventor： Ranjit Ray ,  Ratna Ray ,  Arnab Basu ,  Yie-Hwa Chang

IPC: G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475 ,  C12N9/99

CPC classification number: C07K14/4747 ,  C07K14/4703 ,  C07K14/4716 ,  C12P21/06 ,  G01N2800/085

Abstract: The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocytes as containing a death factor that induces apoptosis of activated liver stellate cells. This pro-apoptotic activity is shown to be associated with the peptide sequence of the actin depolymerizing molecule gelsolin and or fragments thereof. The apoptotic activity is increased upon incubation of immunoglobulins with the stellate death factor.

Abstract translation: 本发明提供了选择性抑制星状细胞增殖的组合物和方法，其对于肝损伤时肝纤维化的发展是重要的。 本发明描述了来自永生化肝细胞的条件培养基，其含有诱导活化的肝星状细胞凋亡的死亡因子。 该促凋亡活性显示与肌动蛋白解聚分子凝溶胶蛋白及其片段的肽序列相关。 免疫球蛋白与星状死亡因子的孵育时，凋亡活性增加。

公开(公告)号：US20110024877A1

公开(公告)日：2011-02-03

申请号：US12901780

申请日：2010-10-11

Applicant: Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

Inventor： Arnab Basu ,  Max Robinson ,  Ben Cantwell ,  Andy Brinkman

IPC: H01L29/22

CPC classification number: H01L21/02568 ,  C30B11/00 ,  C30B29/48 ,  H01L21/02378 ,  H01L21/02381 ,  H01L21/02395 ,  H01L21/02474 ,  H01L21/02477 ,  H01L21/0248 ,  H01L21/02502 ,  H01L21/02505 ,  H01L21/0251 ,  H01L21/02562 ,  H01L21/02617 ,  Y10T428/21 ,  Y10T428/26 ,  Y10T428/266 ,  Y10T428/31678

Abstract: A structure including a substrate, an intermediate layer provided and formed directly onto the substrate, a transition region, and a group II-VI bulk crystal material provided and formed as an extension of the transition region. The transition region acts to change the structure from the underlying substrate to that of the bulk crystal. In a method of manufacture, a similar technique can be used for growing the transition region and the bulk crystal layer.

Abstract translation: 包括基板，直接设置并形成在基板上的中间层，过渡区域和设置并形成为过渡区域的延伸的II-VI族块状晶体材料的结构。 过渡区域用于将结构从下面的衬底改变为本体晶体的结构。 在制造方法中，可以使用类似的技术来生长过渡区域和体晶层。

公开(公告)号：US20090148832A1

公开(公告)日：2009-06-11

申请号：US12365523

申请日：2009-02-04

Applicant: RATNA RAY ,  RANJIT RAY ,  ARNAB BASU ,  TATSUO KANDA

Inventor： RATNA RAY ,  RANJIT RAY ,  ARNAB BASU ,  TATSUO KANDA

IPC: C12Q1/70 ,  C12N7/00

CPC classification number: C12N7/00 ,  A61K2039/525 ,  C12N2770/24251 ,  C12Q1/18 ,  G01N33/5067 ,  G01N2333/18

Abstract: The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77) transfected immortal human hepatocyte (IHH) capable of generating infectious HCV 1a virus particles in culture. Also disclosed are methods of using the cell line, or HCV 1a virus particles derived from said cell line, to screen for potential therapeutic agents which interfere with HCV 1a virus propagation to treat hepatic disease.

Abstract translation: 本发明提供了一种在培养中能够产生感染性丙型肝炎病毒1a（HCV1a）颗粒的细胞系。 公开了能够在培养中产生感染性HCV 1a病毒颗粒的HCV 1a（克隆H77）转染的永生人肝细胞（IHH）的组合物和方法。 还公开了使用细胞系或源自所述细胞系的HCV 1a病毒颗粒筛选干扰HCV 1a病毒繁殖以治疗肝脏疾病的潜在治疗剂的方法。

公开(公告)号：US20080283761A1

公开(公告)日：2008-11-20

申请号：US12152863

申请日：2008-05-16

Applicant: Max Robinson ,  Arnab Basu

Inventor： Max Robinson ,  Arnab Basu

IPC: G01T1/24

CPC classification number: G01N23/04 ,  G01N23/2076 ,  G01V5/0016

Abstract: A method and apparatus for obtaining radiation transmission data including providing a radiation source, e.g., x-ray or gamma-ray source, and a radiation detector system, e.g., x-ray or gamma-ray detection system, spaced therefrom to define a scanning zone therebetween, the detector system capable of detecting and collecting spectroscopically resolvable information about incident radiation. Collecting a dataset of information about radiation incident including transmissivity of an object in the scanning zone at at least one scanning position from radiation transmitted through the object and received at the detector system. Resolving each dataset spectroscopically across a plurality of frequency bands within the spectrum of the source; at least one of the frequency bands corresponding to a characteristically scattered wavelength of a target species to be identified. The absence of or substantial reduction in a transmitted signal intensity at the frequency band is interpreted as the presence of the said target species.

Abstract translation: 一种用于获得辐射传输数据的方法和装置，包括提供辐射源，例如x射线或γ射线源，以及辐射检测器系统，例如与其间隔开的x射线或γ射线检测系统，以限定扫描 区域，检测器系统能够检测和收集关于入射辐射的光谱可分辨的信息。 收集关于辐射入射的信息的数据集，其中包括在扫描区域中的物体在至少一个扫描位置处的透射率，从辐射透射通过物体并在检测器系统处接收。 在光谱范围内的多个频带内光谱地分解每个数据集; 至少一个频带对应于待识别的目标物种的特征散射波长。 在频带处的传输信号强度的不存在或实质上的减少被解释为所述目标物种的存在。