公开(公告)号：US20060219576A1

公开(公告)日：2006-10-05

申请号：US11277731

申请日：2006-03-28

申请人： Arvind Jina

发明人： Arvind Jina

IPC分类号： G01F1/64 ,  G01N33/487

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  A61B5/14865

摘要： One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing area in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending from the sensing area into substantially the entire interior space of the tissue piercing elements; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing area. Another aspect of the invention provides a method of in vivo monitoring of an individual's interstitial fluid glucose concentration including the following steps: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each having a distal opening, a proximal opening, an interior space extending between the distal and proximal openings, and a sensing fluid filling substantially the entire interior space; and sensing a glucose concentration of the sensing fluid.

摘要翻译： 本发明的一个方面提供一种具有多个组织刺穿元件的葡萄糖监测器，每个组织刺穿元件具有远端开口，在远端和近端开口之间延伸的近端开口和内部空间; 与组织刺穿元件的近端开口流体连通的感测区域; 感测从所述感测区域延伸到所述组织刺穿元件的大致整个内部空间的流体; 以及适于检测感测区域内的感测流体中的葡萄糖浓度的葡萄糖传感器。 本发明的另一方面提供一种体内监测个体间质液葡萄糖浓度的方法，包括以下步骤：将多个组织刺穿元件的远端插入穿过个体皮肤的角质层区域，每个组织刺穿元件具有 远端开口，近端开口，在远端和近端开口之间延伸的内部空间，以及基本上填充整个内部空间的感测流体; 并感测感测流体的葡萄糖浓度。

公开(公告)号：US20060148096A1

公开(公告)日：2006-07-06

申请号：US10533350

申请日：2003-11-05

申请人： Arvind Jina

发明人： Arvind Jina

IPC分类号： G01N33/558

CPC分类号： G01N33/723 ,  G01N33/558 ,  G01N33/721 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

摘要： A system for treating a blood sample (700) having an analyte of interest comprises a strip (200) having a membrane (218), respective portions (216, 220 and 222, or 300) which are provided for receiving the sample, for lysing cells of the sample to liberate hemoglobin, and for capturing glycated hemoglobin. The latter two portions (220 and 222, or 300) of the membrane are treated with lysing and capture agents, respectively. A portion of the strip (214 or 230 or 240) is provided for holding an eluting agent and for releasing the agent upon a release condition. A system for detecting analyte comprises an optical subsystem (550) that is aligned with the strip to provide a signal corresponding to an amount of analyte, and an electronic subsystem (650) for processing the signal (560) to provide a result, such as an amount or percentage of glycated hemoglobin. To use these systems, the user simply applies a small sample (700) to the membrane (218) and closes a door (10) of the detection system over the strip (200) such that the door triggers the release of the eluting agent. No sample pre-treatment is required. The preferably handheld system (100) is a simple and convenient monitoring tool for the user, such as a diabetic patient who must monitor blood glucose on an on-going basis. While the systems are useful in the monitoring of blood glucose, they may be used for treating a sample other than blood and detecting an analyte other than an analyte in blood.

摘要翻译： 用于处理具有感兴趣分析物的血液样品（700）的系统包括具有膜（218）的条带（200），被设置用于接收样品的相应部分（216,220和222或300），用于裂解 样品的细胞释放血红蛋白，并用于捕获糖化血红蛋白。 膜的后两部分（220和222或300）分别用裂解和捕获剂处理。 提供条带（214或230或240）的一部分用于容纳洗脱剂并在释放条件下释放该药剂。 用于检测分析物的系统包括光学子系统（550），其与条带对准以提供对应于分析物的量的信号;以及电子子系统（650），用于处理信号（560）以提供结果，例如 糖化血红蛋白的量或百分数。 为了使用这些系统，用户简单地将小样品（700）施加到膜（218）并且关闭带（200）上的检测系统的门（10），使得门触发洗脱剂的释放。 不需要样品预处理。 优选的手持系统（100）是用于用户的简单和方便的监测工具，例如必须一直监测血糖的糖尿病患者。 虽然这些系统可用于监测血糖，但它们可用于治疗血液以外的样品，并检测血液中的分析物以外的分析物。

公开(公告)号：US20080058726A1

公开(公告)日：2008-03-06

申请号：US11468732

申请日：2006-08-30

申请人： Arvind Jina ,  Bee Lee Chua ,  Shashi Desai ,  Ashok Parmar ,  Abdel-Nasser Kawde

发明人： Arvind Jina ,  Bee Lee Chua ,  Shashi Desai ,  Ashok Parmar ,  Abdel-Nasser Kawde

IPC分类号： A61M5/32

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053

摘要： A surface penetration device, methods of use and methods of manufacture thereof are provided. The device includes a substrate supporting a tapered elongate structure extending from and supported by the substrate upper surface. The elongate structure includes a distal portion, a proximal portion supported at the substrate upper surface, a lumen, and a plurality of lumen openings. A cross section of the lumen is asymmetrical and includes a fist defining dimension that is larger than a second defining dimension. The lumen extends from the lumen openings and through the elongate structures. The lumen openings are positioned proximal to the elongate structure's distal portion. In one embodiment an array of a plurality of the elongate structures are provided. In another embodiment, the elongate structures are microneedles.

摘要翻译： 提供了表面穿透装置，使用方法及其制造方法。 该装置包括支撑从衬底上表面延伸并由其支撑的锥形细长结构的衬底。 细长结构包括远侧部分，支撑在基底上表面的近端部分，内腔和多个管腔开口。 管腔的横截面是不对称的，并且包括大于第二限定尺寸的拳头定义尺寸。 内腔从腔开口延伸并穿过细长结构。 管腔开口位于细长结构的远侧部分附近。 在一个实施例中，提供了多个细长结构的阵列。 在另一个实施例中，细长结构是微针。

公开(公告)号：US5489371A

公开(公告)日：1996-02-06

申请号：US37016

申请日：1993-03-25

申请人： Jose P. Joseph ,  Arvind Jina ,  Michael J. Tierney

发明人： Jose P. Joseph ,  Arvind Jina ,  Michael J. Tierney

IPC分类号： G01N27/416 ,  G01N33/28 ,  G01N27/403

CPC分类号： G01N33/2888

摘要： This invention relates to a sensor for the direct and continuous measurement of the electrochemical properties of compounds in a high resistivity liquid. The sensor has a housing which includes a porous hydrophilic membrane which may be made of a ceramic, and contains an electrolytic solution. The membrane permits the passage of a portion of the electrolytic solution into the pores thereby facilitating the formation of an interface between the electrolytic solution and the high resistivity liquid and allowing extraction of the compounds in the high resistivity liquid into the electrolytic solution. A porous sensing electrode is positioned directly on the membrane for detecting and measuring the concentration of the compounds extracted from the high resistivity fluid.

摘要翻译： 本发明涉及用于直接和连续地测量化合物在高电阻率液体中的电化学性质的传感器。 传感器具有壳体，其包括可由陶瓷制成并包含电解液的多孔亲水膜。 膜允许一部分电解溶液进入孔中，从而便于在电解溶液和高电阻率液体之间形成界面，并允许将高电阻率液体中的化合物提取到电解液中。 多孔感应电极直接位于膜上，用于检测和测量从高电阻率流体提取的化合物的浓度。

公开(公告)号：US5304293A

公开(公告)日：1994-04-19

申请号：US882459

申请日：1992-05-11

申请人： Michael J. Tierney ,  Arvind Jina ,  Jose Joseph ,  Marc Madou

发明人： Michael J. Tierney ,  Arvind Jina ,  Jose Joseph ,  Marc Madou

IPC分类号： G01N27/49 ,  G01N27/26

CPC分类号： G01N27/4045

摘要： A sensor for gaseous and vaporous species is disclosed. The sensor comprises an electrically insulated substrate which contains small pores passing completely through it. Electrodes consisting of metallic or semiconductor material are deposited onto the top surface of the substrate. In a first embodiment of the invention, an electrolyte is placed on the top surface of the substrate in such a manner as to create a gas or vapor permeable electrolyte layer on top of the electrodes. In a second embodiment of the invention, the electrolyte is applied to the bottom surface of the substrate and seeps up through the porous holes of the substrate until it makes contact with the electrodes. Both embodiments result in a gas sensor with a response time dependent upon the gas flow rate rather than the time required for the gas to be dissolved in the electrolyte layer and be detected.

摘要翻译： 公开了一种用于气态和气态物质的传感器。 传感器包括一个电绝缘的基底，其中包含完全通过它的小孔。 由金属或半导体材料组成的电极沉积在基板的顶表面上。 在本发明的第一实施例中，电解质以在电极顶部产生气体或透气电解质层的方式被放置在基板的顶表面上。 在本发明的第二实施例中，将电解质施加到基底的底表面，并通过衬底的多孔孔渗透直到其与电极接触。 两个实施例都导致气体传感器具有取决于气体流速的响应时间，而不是气体溶解在电解质层中并被检测所需的时间。