公开(公告)号：US20120170585A1

公开(公告)日：2012-07-05

申请号：US12981033

申请日：2010-12-29

申请人： Ashwani Kumar Mehra ,  Srikar Rajamani ,  Saurabh Saksena

发明人： Ashwani Kumar Mehra ,  Srikar Rajamani ,  Saurabh Saksena

IPC分类号： H04L12/56

CPC分类号： H04L41/12 ,  H04L41/0654 ,  H04L43/04 ,  H04L43/50 ,  H04L45/24 ,  H04L45/28 ,  H04L45/74 ,  H04L49/25 ,  H04W24/08

摘要： An apparatus includes a destination edge device configured to receive a first validation packet according to a switch fabric validation protocol. The destination edge device is configured to validate multiple data paths through a distributed switch fabric from a source edge device to the destination edge device based on the first validation packet. The destination edge device is configured to send, in response to receiving the first validation packet, a second validation packet to a peripheral processing device. The destination edge device is also configured to send the second validation packet according to a validation protocol different from the first validation protocol.

摘要翻译： 一种装置包括：目的边缘装置，被配置为根据交换结构验证协议接收第一验证分组。 目的地边缘设备被配置为基于第一验证分组来验证从源边缘设备到目的地边缘设备的分布式交换结构的多个数据路径。 目的地边缘设备被配置为响应于接收到第一验证分组而向外围处理设备发送第二验证分组。 目的地边缘设备还被配置为根据与第一验证协议不同的验证协议来发送第二验证分组。

公开(公告)号：US20100239691A1

公开(公告)日：2010-09-23

申请号：US12666008

申请日：2008-06-20

申请人： Adrie J.C. Steyn ,  Ashwani Kumar

发明人： Adrie J.C. Steyn ,  Ashwani Kumar

IPC分类号： A61K33/00 ,  G01N33/573 ,  A61K38/19

CPC分类号： G01N33/5695 ,  G01N2333/91205 ,  G01N2500/04

摘要： Methods for screening for agents that modulate the activation state, i.e., active growth or persistence, of Mycobacterium tuberculosis (Mtb), methods of treating an Mtb infection in a subject using agents identified by the screening methods, and methods for screening for a latent Mtb infection in a subject are disclosed. The screening methods involve contacting a Mtb sensor kinase with an agent to be tested, then detecting the response of the Mtb sensor kinase to modulating ligands or detecting changes in the oxidation state of the heme iron of the Mtb sensor kinase. The methods for treating an Mtb infection in a subject involve administering a therapeutically effective amount of an agent identified by the screening methods. The methods for screening for a latent Mtb infection in a subject involve detecting carbon monoxide or nitric oxide binding to heme iron of Mtb sensor kinases.

摘要翻译： 用于筛选调节结核分枝杆菌（Mtb）的活化状态，即活性生长或持久性的试剂的方法，使用通过筛选方法鉴定的试剂处理受试者中的Mtb感染的方法，以及用于筛选潜伏性Mtb 披露了受试者的感染。 筛选方法包括将Mtb传感器激酶与待测试的试剂接触，然后检测Mtb传感器激酶对调节配体的反应或检测Mtb传感器激酶的血红素铁的氧化状态的变化。 用于治疗受试者的Mtb感染的方法包括施用治疗有效量的通过筛选方法鉴定的药剂。 用于筛选受试者潜伏性Mtb感染的方法涉及检测一氧化碳或一氧化氮与Mtb传感器激酶的血红素结合。

公开(公告)号：US07790689B2

公开(公告)日：2010-09-07

申请号：US11755164

申请日：2007-05-30

申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

IPC分类号： A61K31/7008 ,  A61K31/7012 ,  A61K31/34 ,  C07H5/04 ,  C07H5/06 ,  C07D323/02 ,  C07D317/00

CPC分类号： C07H13/12 ,  C07H9/04

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20100007676A1

公开(公告)日：2010-01-14

申请号：US12172530

申请日：2008-07-14

申请人： Ashwani Kumar ,  Adrian Fraser ,  Philip O. Williams

发明人： Ashwani Kumar ,  Adrian Fraser ,  Philip O. Williams

IPC分类号： G09G5/00 ,  G06T17/40

CPC分类号： G06T19/20 ,  G06T2219/2004 ,  G06T2219/2008

摘要： A system, method, and computer program for component scattering, comprising calculating a bounding box for each of a plurality of parts; calculating a centroid corresponding to each of said bounding boxes; placing a first part having a bounding box and a centroid at said start position, and; placing said plurality of parts in a pre-determined direction from said first part; whereby in a single operation said plurality of parts are logically added to an assembly view in a pre-determined manner, and appropriate means and computer-readable instructions.

摘要翻译： 一种用于分量散射的系统，方法和计算机程序，包括计算多个部分中的每一个的边界框; 计算对应于每个所述边界框的质心; 在所述起始位置放置具有边界框和质心的第一部分; 将所述多个部件从所述第一部件放置在预定方向上; 由此在单个操作中，所述多个部件以预定方式逻辑地添加到组装视图，以及适当的装置和计算机可读指令。

公开(公告)号：US07496784B1

公开(公告)日：2009-02-24

申请号：US11971911

申请日：2008-01-10

申请人： Beth Ann Peterson ,  Todd C. Sorenson ,  Matthew Joseph Kalos ,  Ashwani Kumar ,  James Lamar Hood

发明人： Beth Ann Peterson ,  Todd C. Sorenson ,  Matthew Joseph Kalos ,  Ashwani Kumar ,  James Lamar Hood

IPC分类号： G06F11/00

CPC分类号： G06F11/0793 ,  G06F11/0727 ,  G06F11/10

摘要： A method is provided to protect against ill-behaved microcode by balancing between an actual occurrence of a hardware problem and a microcode bug setting a flag appearing as a hardware problem. In this method, the error recovery is performed only on a single piece of hardware and no further error recovery action is taken on other pieces of similar hardware. The approach addresses the problem by treating a hit on one card as a hardware problem, but as a bug on subsequent cards. The invention keeps track of whether or not the same event has occurred on the same type of hardware so not to take action on more than one instance of the hardware. Subsequent hits on another instance of the hardware will not trigger the hardware related recovery on additional hardware.

摘要翻译： 提供了一种通过平衡实际发生的硬件问题和设置出现为硬件问题的标志的微代码错误来防止不良行为微代码的方法。 在该方法中，仅在单个硬件上执行错误恢复，并且不对其他类似硬件进行进一步的错误恢复操作。 该方法通过将一张卡上的打击视为硬件问题来解决问题，但是作为后续卡上的错误。 本发明跟踪相同类型的硬件上是否发生了相同的事件，所以不对多个硬件实例采取行动。 在另一个硬件实例上的后续命中不会触发额外硬件上的硬件相关恢复。

公开(公告)号：US5812839A

公开(公告)日：1998-09-22

申请号：US851141

申请日：1997-05-05

申请人： Bradley D. Hoyt ,  Glenn J. Hinton ,  David B. Papworth ,  Ashwani Kumar Gupta ,  Michael Alan Fetterman ,  Subramanian Natarajan ,  Sunil Shenoy ,  Reynold V. D'Sa

发明人： Bradley D. Hoyt ,  Glenn J. Hinton ,  David B. Papworth ,  Ashwani Kumar Gupta ,  Michael Alan Fetterman ,  Subramanian Natarajan ,  Sunil Shenoy ,  Reynold V. D'Sa

IPC分类号： G06F9/38

CPC分类号： G06F9/3806 ,  G06F9/322 ,  G06F9/3844 ,  G06F9/3863 ,  G06F9/3885

摘要： A four stage branch instruction resolution system for a pipelined processor is disclosed. A first stage of the branch instruction resolution system predicts the existence and outcome of branch instructions within an instruction stream such that an instruction fetch unit can continually fetch instructions. A second stage decodes all the instructions fetched. If the decode stage determines that a branch instruction predicted by the first stage is not a branch instruction, the decode stage flushes the pipeline and restarts the processor at a corrected address. The decode stage verifies all branch predictions made by the branch prediction stage. Finally, the decode stage makes branch predictions for branches not predicted by the branch prediction stage. A third stage executes all the branch instructions to determine a final branch outcome and a final branch target address. The branch execution stage compares the final branch outcome and final branch target address with the predicted branch outcome and predicted branch target address to determine if the processor must flush the front-end of the microprocessor pipeline and restart at a corrected address. A final branch resolution stage retires all branch instructions. The retirement stage ensures that any instructions fetched after a mispredicted branch are not committed into permanent state.

摘要翻译： 公开了一种用于流水线处理器的四级分支指令解析系统。 分支指令解析系统的第一阶段预测指令流内分支指令的存在和结果，使得指令获取单元可以连续地获取指令。 第二阶段解码所有提取的指令。 如果解码级确定由第一级预测的分支指令不是分支指令，则解码级别刷新流水线并以校正的地址重新启动处理器。 解码阶段验证分支预测阶段所做的所有分支预测。 最后，解码阶段对分支预测阶段未预测的分支进行分支预测。 第三阶段执行所有分支指令以确定最终分支结果和最终分支目标地址。 分支执行阶段将最终分支结果和最终分支目标地址与预测的分支结果和预测分支目标地址进行比较，以确定处理器是否必须冲洗微处理器流水线的前端并以修正的地址重新启动。 最终的分支解决阶段退出所有分支指令。 退休阶段确保在错误预测的分支之后提取的任何指令不会被永久保留。

公开(公告)号：US08795978B2

公开(公告)日：2014-08-05

申请号：US12666008

申请日：2008-06-20

申请人： Adrie J. C. Steyn ,  Ashwani Kumar

发明人： Adrie J. C. Steyn ,  Ashwani Kumar

IPC分类号： C12Q1/48 ,  C12Q1/02

CPC分类号： G01N33/5695 ,  G01N2333/91205 ,  G01N2500/04

摘要： Methods for screening for agents that modulate the activation state, i.e., active growth or persistence, of Mycobacterium tuberculosis (Mtb), methods of treating an Mtb infection in a subject using agents identified by the screening methods, and methods for screening for a latent Mtb infection in a subject are disclosed. The screening methods involve contacting a Mtb sensor kinase with an agent to be tested, then detecting the response of the Mtb sensor kinase to modulating ligands or detecting changes in the oxidation state of the heme iron of the Mtb sensor kinase. The methods for treating an Mtb infection in a subject involve administering a therapeutically effective amount of an agent identified by the screening methods. The methods for screening for a latent Mtb infection in a subject involve detecting carbon monoxide or nitric oxide binding to heme iron of Mtb sensor kinases.

摘要翻译： 用于筛选调节结核分枝杆菌（Mtb）的活化状态，即活性生长或持久性的试剂的方法，使用通过筛选方法鉴定的试剂处理受试者中的Mtb感染的方法，以及用于筛选潜伏性Mtb 披露了受试者的感染。 筛选方法包括将Mtb传感器激酶与待测试的试剂接触，然后检测Mtb传感器激酶对调节配体的反应或检测Mtb传感器激酶的血红素铁的氧化状态的变化。 用于治疗受试者的Mtb感染的方法包括施用治疗有效量的通过筛选方法鉴定的药剂。 用于筛选受试者潜伏性Mtb感染的方法涉及检测一氧化碳或一氧化氮与Mtb传感器激酶的血红素结合。

公开(公告)号：US20140172955A1

公开(公告)日：2014-06-19

申请号：US13717647

申请日：2012-12-17

申请人： ULLAS HOLLA P K ,  Ashwani Kumar ,  Pradeep Kumar Warrier

发明人： ULLAS HOLLA P K ,  Ashwani Kumar ,  Pradeep Kumar Warrier

IPC分类号： H04L29/08

CPC分类号： H04L67/10 ,  G06F8/60 ,  G06F9/50 ,  G06F9/5055 ,  H04L67/34

摘要： Various embodiments of systems and methods for distributed mobile enterprise application platform (MEAP) are described herein. In one aspect, the method includes receiving a request to be executed from a mobile device. Based upon the request, one or more middleware components capable of executing the request are determined from one or more remotely located servers. A middleware component from the one or more middleware components is selected for executing the request. The request is sent to the selected middleware component for execution. Based upon the execution, an output is received from the selected middleware component. In one embodiment, the output is stored in a backend system or sent to a portable device from which the request is received. In another embodiment, the output is sent to another middleware component for further execution.

摘要翻译： 本文描述了分布式移动企业应用平台（MEAP）的系统和方法的各种实施例。 一方面，该方法包括从移动设备接收要执行的请求。 基于该请求，从一个或多个远程定位的服务器确定能够执行请求的一个或多个中间件组件。 选择来自一个或多个中间件组件的中间件组件来执行请求。 该请求被发送到所选择的中间件组件以供执行。 基于执行，从所选择的中间件组件接收输出。 在一个实施例中，输出被存储在后端系统中或者被发送到从其接收到该请求的便携式设备。 在另一个实施例中，将输出发送到另一个中间件组件以进一步执行。

公开(公告)号：US20120170575A1

公开(公告)日：2012-07-05

申请号：US12981025

申请日：2010-12-29

申请人： Ashwani Kumar Mehra

发明人： Ashwani Kumar Mehra

IPC分类号： H04L12/50

CPC分类号： H04L45/7453 ,  H04L41/00 ,  H04L45/24

摘要： An apparatus includes a replication engine of a switch module of a multi-stage switch. The replication engine is configured to receive a first validation packet from an input port of the switch module. The replication engine is configured to determine multiple output ports of the switch module to which a data packet can be sent to reach a destination device associated with the first validation packet. The replication engine is configured to define multiple second validation packets based on a number of output ports from the multiple output ports such that each second validation packet from the multiple second validation packets is uniquely associated with an output port from the multiple output ports. The replication engine is configured to send the multiple second validation packets to an output module configured to forward each second validation packet from the multiple second validation packets to its associated output port.

摘要翻译： 一种装置包括多级开关的开关模块的复制引擎。 复制引擎被配置为从交换机模块的输入端口接收第一验证分组。 复制引擎被配置为确定可以向其发送数据分组的多个输出端口到达与第一验证分组相关联的目的地设备。 复制引擎被配置为基于来自多个输出端口的输出端口的数量来定义多个第二验证分组，使得来自多个第二验证分组的每个第二验证分组与来自多个输出端口的输出端口唯一地相关联。 复制引擎被配置为将多个第二验证分组发送到输出模块，输出模块被配置为将每个第二验证分组从多个第二验证分组转发到其相关联的输出端口。

公开(公告)号：US07702786B2

公开(公告)日：2010-04-20

申请号：US10403310

申请日：2003-03-27

申请人： Mark Steven Bayus ,  Roger Gregory Hathorn ,  Matthew Joseph Kalos ,  Ashwani Kumar ,  Takashi Suzuki

发明人： Mark Steven Bayus ,  Roger Gregory Hathorn ,  Matthew Joseph Kalos ,  Ashwani Kumar ,  Takashi Suzuki

IPC分类号： G06F15/173

CPC分类号： H04L1/22

摘要： Disclosed are a method, apparatus, and computer program product to reduce the detrimental effects of taking resources offline. A resource is taken offline in a storage network by quiescing activity to the resource providing notification that the resource will become unavailable, and taking the resource offline.

摘要翻译： 公开了减少离线资源的不利影响的方法，装置和计算机程序产品。 通过将资源停留在资源提供通知中资源将变得不可用，并使资源脱机，资源将在存储网络中脱机。