公开(公告)号：US08216296B2

公开(公告)日：2012-07-10

申请号：US11613827

申请日：2006-12-20

申请人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

发明人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

IPC分类号： A61F2/84

CPC分类号： A61F2/95 ,  A61F2/966 ,  A61F2002/9517 ,  A61M2025/0098

摘要： The invention is directed a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device.

摘要翻译： 本发明涉及一种用于在包括控制手柄和导管部分的身体中植入自扩张医疗装置的递送系统。 所述导管部分包括覆盖所述收缩的医疗装置的外限制构件，具有包括安装所述医疗装置的区域的远端的内导管构件和可移除地附接到所述控制手柄的外护套。 当外部限制构件缩回时，外护套产生用于导管部分的导管，以防止内部导管构件轴向移动。 控制手柄具有可旋转的指轮，以致动附接到外约束构件的近端的缩回机构，该缩回机构沿约束方向移动约束构件以展开医疗装置。

公开(公告)号：US20110147251A1

公开(公告)日：2011-06-23

申请号：US12969238

申请日：2010-12-15

申请人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

发明人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

IPC分类号： B65D85/00

CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075

摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.

摘要翻译： 用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。 组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。 与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。 阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。 然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。 包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。 该包装系统便于安装用于快速连接阀注入过程的阀输送管。

公开(公告)号：US20100331972A1

公开(公告)日：2010-12-30

申请号：US12821628

申请日：2010-06-23

申请人： Rafael Pintor ,  Mark Chau ,  Travis Oba ,  August Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey Cristea ,  Faisal Kalam

发明人： Rafael Pintor ,  Mark Chau ,  Travis Oba ,  August Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey Cristea ,  Faisal Kalam

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2439 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/005 ,  A61F2250/006

摘要： A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.

摘要翻译： 提供了一种快速连接的心脏瓣膜假体，可以在手术过程中快速方便地植入。 心脏瓣膜包括基本上不可膨胀的不可压缩的人造瓣膜和塑性可扩张的联接支架，从而使得能够在不缝合的情况下连接到环形空间。 可以提供少量的导向缝线用于主动脉瓣取向。 假体瓣膜可以是具有连接有联接支架的缝合环的市售阀。 联接支架可以从锥形展开形状扩展到圆锥形膨胀形状，并且可以包括连接在轴向延伸柱之间的腹板状支柱。 用于展开的系统和方法包括气球导管通过的中空两件式手柄。 与心脏瓣膜一起存储阀保持器，并且手柄容易地附接到其上以改善阀门准备步骤。

公开(公告)号：US20100145431A1

公开(公告)日：2010-06-10

申请号：US12703535

申请日：2010-02-10

申请人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

发明人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

IPC分类号： A61F2/84

CPC分类号： A61F2/95 ,  A61F2/966 ,  A61F2002/9517 ,  A61M2025/0098

摘要： The invention is directed a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device.

摘要翻译： 本发明涉及一种用于在包括控制手柄和导管部分的身体中植入自扩张医疗装置的递送系统。 所述导管部分包括覆盖所述收缩的医疗装置的外限制构件，具有包括安装所述医疗装置的区域的远端的内导管构件和可移除地附接到所述控制手柄的外护套。 当外部限制构件缩回时，外护套产生用于导管部分的导管，以防止内部导管构件轴向移动。 控制手柄具有可旋转的指轮，以致动附接到外约束构件的近端的缩回机构，该缩回机构沿约束方向移动约束构件以展开医疗装置。

公开(公告)号：US20070142818A1

公开(公告)日：2007-06-21

申请号：US11313477

申请日：2005-12-20

申请人： William Webler ,  August Yambao

发明人： William Webler ,  August Yambao

IPC分类号： A61M31/00

CPC分类号： A61B17/12022 ,  A61B17/1204 ,  A61M25/0021 ,  A61M25/1002 ,  A61M25/10182 ,  A61M25/10188 ,  A61M25/1027 ,  A61M2025/1052

摘要： A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the-latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume.

摘要翻译： 一种受控体积的充气 - 放气装置，用于通过拨打锁定在旋转位置处的手柄来使气囊膨胀以封闭血管，以将柱塞定位在充气 - 放气装置的注射器内的等间隔位置处。 充气 - 放气装置包括可释放的闩锁，以将近端和远端壳体锁定在一起以将柱塞保持在前方用于闭塞，并且分离并保持近端和远端壳体以缩回柱塞用于灌注。 当充气 - 放气装置返回到闩锁位置时，将气囊重新充气到其先前的闭塞直径。 此外，可以使用由较高模量的内部材料共挤出并可与较高模量的内部材料混合的由较低模量的外部材料制成的延伸管，以产生用于充气 - 收缩装置的合适的柔顺性延伸管。 球囊可以具有锥形端部和圆柱形中心部分，使得响应于增加的充气体积的相等增加，其在外径中增加更多相等的增量。

公开(公告)号：US09295539B2

公开(公告)日：2016-03-29

申请号：US13403537

申请日：2012-02-23

申请人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

发明人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

IPC分类号： A61F2/00 ,  A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075

摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly.

摘要翻译： 用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。 组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。 与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。 阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。 然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。 包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。

公开(公告)号：US07758625B2

公开(公告)日：2010-07-20

申请号：US10661406

申请日：2003-09-12

申请人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

发明人： Patrick P. Wu ,  Keif Fitzgerald ,  August Yambao ,  Michael Green

IPC分类号： A61F2/06

CPC分类号： A61F2/95 ,  A61F2/966 ,  A61F2002/9517 ,  A61M2025/0098

摘要： A delivery system for implantation a self-expanding medical device in a body includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device.

摘要翻译： 用于将自扩张医疗装置植入体内的输送系统包括控制手柄和导管部分。 导管部分包括覆盖塌陷的医疗装置的外限制构件，具有包括安装有医疗装置的区域的远端的内导管构件和可移除地附接到控制手柄的外护套。 当外部限制构件缩回时，外护套产生用于导管部分的导管，以防止内部导管构件轴向移动。 控制手柄具有可旋转的指轮，以致动附接到外约束构件的近端的缩回机构，该缩回机构沿约束方向移动约束构件以展开医疗装置。

公开(公告)号：US20100161036A1

公开(公告)日：2010-06-24

申请号：US12635471

申请日：2009-12-10

申请人： Rafael Pintor ,  Mark Chau ,  Travis Oba ,  August Yambao ,  Louis Campbell ,  Tammy Huntley ,  Qinggeng Zeng ,  Carey Cristea ,  Faisal Kalam

发明人： Rafael Pintor ,  Mark Chau ,  Travis Oba ,  August Yambao ,  Louis Campbell ,  Tammy Huntley ,  Qinggeng Zeng ,  Carey Cristea ,  Faisal Kalam

IPC分类号： A61F2/82 ,  A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61F2250/006

摘要： A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.

摘要翻译： 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。 基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。 阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架，由此固定阀部件相对于基底支架的位置。 人造瓣膜可以是市售的，具有缝合环的阀门，并且联接支架附接到缝合环。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。 提供了基于导管的系统和部署方法。

公开(公告)号：US20100131039A1

公开(公告)日：2010-05-27

申请号：US12618023

申请日：2009-11-13

申请人： Mark Chau ,  Travis Oba ,  Tammy Huntley ,  Qinggang Zeng ,  August Yambao ,  Rafael Pintor

发明人： Mark Chau ,  Travis Oba ,  Tammy Huntley ,  Qinggang Zeng ,  August Yambao ,  Rafael Pintor

IPC分类号： A61F2/82

CPC分类号： A61F2/2433 ,  A61F2/2418 ,  A61F2/243 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0003

摘要： A system for expanding a device in a conduit or orifice of a human body includes an expansion device that is movable from a first configuration to a second configuration. External surfaces of the expansion device can collectively have a non-cylindrical cross-section relative to a main axis of the expansion device, such that the external surfaces of the expansion device generally conform to the anatomical shape of the conduit or orifice when the expansion device is in the second configuration.

摘要翻译： 一种用于在人体的管道或孔中扩张装置的系统包括可从第一构型移动到第二构造的膨胀装置。 膨胀装置的外表面可以相对于膨胀装置的主轴线共同具有非圆柱形横截面，使得当膨胀装置的膨胀装置的外表面大致符合导管或孔口的解剖形状时 处于第二个配置。

公开(公告)号：US08869982B2

公开(公告)日：2014-10-28

申请号：US12969238

申请日：2010-12-15

申请人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

发明人： Fred Hodshon ,  Rafael Pintor ,  August Yambao ,  Abhishek Gautam ,  Louis A. Campbell ,  Lawrence Farhat ,  Tammy Huntley ,  Faisal Kalam ,  Travis Oba ,  Qinggang Zeng

IPC分类号： A61B17/06 ,  A61B19/02 ,  A61L15/00 ,  A61F2/00 ,  A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075

摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.

摘要翻译： 用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。 组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。 与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。 阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。 然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。 包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。 该包装系统便于安装用于快速连接阀注入过程的阀输送管。