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公开(公告)号：US20220142795A1
公开(公告)日：2022-05-12
申请号：US17580928
申请日：2022-01-21
发明人： Wenjiao LIN , Wenchao FU
摘要： An absorbable stent includes an absorbable matrix. The matrix includes a number of wave-shaped rings connected by connection units and arranged in an axial direction. The wave-shaped ring includes a number of waves arranged in a circumferential direction. A peak, a valley and a support connecting the peak and the valley form the wave. Two adjacent wave-shaped rings and the connection unit form a closed side supporting unit. The matrix has a volume of 4 μm to 40 μm per unit blood vessel area. The absorbable stent has sufficient radial supporting strength of no less than 55 kPa for clinical applications. Moreover, the volume of the matrix per unit blood vessel area is less than volumes of existing stents. When the absorbable stent and existing stents are made of the same material, the absorbable stent has a shorter degradation and absorption cycle.
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公开(公告)号：US20210393858A1
公开(公告)日：2021-12-23
申请号：US17288685
申请日：2019-10-14
发明人： Wenchao FU , Wenjiao LIN , Li QIN
摘要： An implantable device including a metal substrate; that contains particles having a size of 1 μm or more; if the wall thickness of the metal substrate is greater than or equal to 0.04 mm and less than or equal to 0.12 mm, the largest particle size is less than or equal to 15 μm and the average content of the particles is less than or equal to 40 ppm; if the wall thickness of the metal substrate is greater than 0.12 mm and less than or equal to 0.2 mm, the largest particle size is less than or equal to 20 μm and the average content of the particles is less than or equal to 100 ppm; The size of the particles and the average content of the particles are reasonably controlled according to the wall thickness of the metal substrate, improving the plastic deformation capability of the implantable device.
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公开(公告)号：US20220062015A1
公开(公告)日：2022-03-03
申请号：US17418409
申请日：2019-10-31
发明人： Liping CHEN , Wenjiao LIN , Wanqian ZHANG
摘要： A drug eluting device and a preparation method thereof are disclosed. The drug eluting device includes a substrate and a drug coating arranged on the substrate. The substrate has an outer wall, side walls, and an inner wall, the drug coating contains active drug and a drug carrier, the active drug is dispersed in the drug carrier, the drug coating covers the outer wall, the side walls, and the inner wall of the substrate, and the content of the active drug on both the outer wall and the side walls are greater than the content of the active drug on the inner wall; or, the active drug is only distributed on the outer wall and the side walls, and the inner wall does not contain the active drug. The drug eluting device is less prone to coating peeling off from the substrate.
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公开(公告)号：US20210402068A1
公开(公告)日：2021-12-30
申请号：US17288184
申请日：2019-10-31
发明人： Wenjiao LIN , Dong BIAN
摘要： An absorbable implantable device, including an iron-based substrate, and a zinc-containing protective layer and a corrosion promoting layer provided on the iron-based substrate. The iron-based substrate has an outer wall and an inner wall. The zinc-containing protective layer covers the outer wall and the inner wall of the iron-based substrate. The corrosion promoting layer covers the zinc-containing protective layer. The thickness ratio of the zinc-containing protective layer located on the outer wall to the corrosion promoting layer located on the outer wall is less than the thickness ratio of the zinc-containing protective layer located on the inner wall to the corrosion promoting layer located on the inner wall. The absorbable implantable device has a low risk of thrombosis and can meet the requirements of early support and later rapid corrosion.
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公开(公告)号：US11623028B2
公开(公告)日：2023-04-11
申请号：US15766842
申请日：2016-06-14
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin , Gui Zhang , Li Qin
IPC分类号： A61K9/00 , A61K33/26 , A61L27/04 , A61L31/08 , A61L27/50 , A61L27/58 , A61L31/02 , A61L31/14 , A61L31/10 , A61L31/06 , A61L31/16
摘要： An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.
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公开(公告)号：US10973948B2
公开(公告)日：2021-04-13
申请号：US16473722
申请日：2017-12-19
发明人： Jun Hu , Deyuan Zhang , Hongtao Sun , Liping Chen
IPC分类号： A61L31/02 , A61L31/06 , A61L31/14 , A61L31/16 , A61L17/00 , A61L17/10 , A61L17/12 , A61L27/04 , A61L27/34 , A61L27/58
摘要： An absorbable iron-based device includes an iron-based matrix and degradable polyester in contact with the surface of the iron-based matrix. The mass fraction of a low-molecular-weight part of the degradable polyester is less than or equal to 5%, and the molecular weight of the low-molecular-weight part is less than 10,000; or the mass fraction of a residual monomer in the degradable polyester is less than or equal to 2%.
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公开(公告)号：US20230118757A1
公开(公告)日：2023-04-20
申请号：US17802467
申请日：2020-05-27
发明人： Wenjiao Lin , Haifeng Li
IPC分类号： G06T7/00
摘要： An evaluation method and system for the corrosion degree of an absorbable stent. The method includes the following steps: obtaining the total number S0 of stent bars of the absorbable stent at the time zero of implantation (S10); separately obtaining n frames of optical coherence tomography (OCT) images of the absorbable stent at the time x of implantation, wherein x is greater than 0, and n is a natural number greater than 1 (S20); determining, according to the n frames of OCT images, the total number Ni of the stent bars corresponding to each frame of OCT image, wherein i is a natural number greater than or equal to 1 and less than or equal to n; and calculating the total number Sx of the stent bars corresponding to the n frames of OCT images at the time x of implantation (I) (S30); determining a corrosion degree Cij of a jth stent bar in an ith frame of OCT image at the time x of implantation, wherein j is a natural number greater than or equal to 1 and less than or equal to Ni (S40); and calculating an overall corrosion degree Cx of the absorbable stent at the time x of implantation according to the following formula: (II) (S50). The evaluation method can be applied to clinical treatment.
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公开(公告)号：US20200215237A1
公开(公告)日：2020-07-09
申请号：US16063798
申请日：2016-06-27
发明人： Ziqiang LIU , Haiping Qi , Wenjiao LIN , Deyuan ZHANG
摘要： An absorbable iron-based alloy implantable medical device, including an iron-based alloy substrate and a degradable polymer coating and a zinc-containing protector which are arranged on the surface of the iron-based alloy substrate. The zinc-containing protector is selected from zinc and/or a zinc alloy, or a mixture of zinc and/or a zinc alloy and a degradable binder. The weight percentage of the zinc and/or zinc alloy in the mixture is greater than or equal to 20% and less than 100%. The zinc-containing protector is capable of delaying the corrosion of the iron-based alloy substrate during the early stage of implantation, such that the iron-based alloy substrate essentially avoids corrosion during the early stage of implantation and the clinical mechanical property requirements for the device in the early stage of implantation can be satisfied.
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公开(公告)号：US20200215235A1
公开(公告)日：2020-07-09
申请号：US16628399
申请日：2018-07-06
发明人： Deyuan ZHANG , Wenjiao LIN , Li QIN , Liping CHEN , Hongtao SUN
IPC分类号： A61L31/02 , A61L31/14 , A61L33/02 , A61L33/06 , A61L27/04 , A61L27/58 , A61L27/18 , A61L31/06
摘要： An implantable apparatus, including at least one corrodible zinc-containing portion, where a content range of zinc in the at least one zinc-containing portion is [30, 50) wt. % and zinc in the zinc-containing portion is an amorphous structure, or a content range of zinc in the at least one zinc-containing portion is [50, 70] wt. %, and a microscopic structure of zinc in the zinc-containing portion is at least one of an amorphous structure, a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14, or a content range of zinc in the at least one zinc-containing portion is (70, 100] wt. % and a microscopic structure of zinc in the zinc-containing portion is at least one of a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14.
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10.发明申请公开(公告)号：US20220339012A1
公开(公告)日：2022-10-27
申请号：US17859563
申请日：2022-07-07
发明人： Deyuan Zhang , Xianmiao Chen , Wenjiao Lin , Xiangdong Liu
IPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , C21D8/10 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26
摘要： A lumen stent preform is provided using a plasma nitriding technology, a preparation method thereof, a method for preparing a lumen stent by using the preform, and a lumen stent obtained according to the method. The preform is manufactured by using pure iron or an iron alloy containing no strong nitrogen compound, has a hardness of 160-250HV0.05/10, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. Alternatively, the preform is an iron alloy containing a strong nitrogen compound, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. The lumen stem preform meets the requirements of a conventional stent for radial strength and plasticity, so that plasma nitriding is applicable to commercial preparation of a lumen stent.
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