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159 条记录 (耗时 0.016 秒)

    Nitroimidazolyl-triazolo-pyridazine compounds
    1.
    发明授权
    Nitroimidazolyl-triazolo-pyridazine compounds 失效
    硝基咪唑基 - 三唑并 - 哒嗪化合物

    公开(公告)号：US3928349A

    公开(公告)日：1975-12-23

    申请号：US33609973

    申请日：1973-02-26

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： BERGER HERBERT ,  GALL RUDI ,  STACH KURT ,  VOMEL WOLFGANG ,  HOFFMANN RITA

    IPC分类号： A61K31/50 ,  A61P31/04 ,  C07D403/04 ,  C07D487/04 ,  C07D237/00

    CPC分类号： C07D487/04

    摘要： Nitroimidazolyl-s-triazolo(4,3-b)pyridazines of the formula:
    wherein R1 and R2 are, individually, hydrogen or a numbe organic radicals or, taken together, can be an alkylene bridge; AND R3 is hydrogen or lower alkyl; or, together with R2, R3 can form an alkylene bridge; N IS 0 OR 1; AND THE PHARMACEUTICALLY COMPATIBLE THEREOF, POSSESS HIGH IN VIVO EFFECTIVENESS AS ANTIMICROBIALS.

    WHEREIN R is hydrogen or lower alkyl optionally substituted in the 2position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula:

    摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪

    Aqueous cholesterol standard solution
    3.
    发明授权
    Aqueous cholesterol standard solution 失效
    胆固醇水溶液标准溶液

    公开(公告)号：US3891573A

    公开(公告)日：1975-06-24

    申请号：US46564074

    申请日：1974-04-30

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： STARY EMIL ,  ROESCHLAU PETER ,  BERNT ERICH

    IPC分类号： G01N33/48 ,  C12Q1/60 ,  G01N33/92 ,  G01N33/96 ,  G01N33/16

    CPC分类号： G01N33/96 ,  C12Q1/60 ,  G01N33/92 ,  Y10T436/104165 ,  Y10T436/108331

    摘要： Highly stable cholesterol standard solution comprising a known amount of cholesterol together with 1 to 20 volume percent of a primary or secondary aliphatic alcohol containing up to 4 carbon atoms; 5 to 20 volume percent hydroxy-polyethoxydodecane or 40 to 60 volume percent diethyleneglycol monobutyl ether; and 0.5 to 5 weight percent sodium chloride and/or 0.01 to 0.5 weight percent alkyl dimethyl benzyl ammonium chloride with 8 to 18 carbon atoms in the alkyl radicals.

    摘要翻译： 包含已知量的胆固醇和1至20体积％含有至多4个碳原子的伯或仲脂族醇的高度稳定的胆固醇标准溶液; 5至20体积％的羟基 - 聚乙氧基十二烷或40至60体积％的二甘醇单丁醚; 和0.5至5重量％的氯化钠和/或0.01至0.5重量％的在烷基中具有8至18个碳原子的烷基二甲基苄基氯化铵。

    Diagnostic agent for detecting bilirubin
    4.
    发明授权
    Diagnostic agent for detecting bilirubin 失效
    用于检测胆红素的诊断剂

    公开(公告)号：US3880588A

    公开(公告)日：1975-04-29

    申请号：US38224173

    申请日：1973-07-24

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： RITTERSDORF WALTER ,  GUTHLEIN WERNER ,  BERGER DIETER ,  REY HANS-GEORG ,  RIECKMANN PETER

    IPC分类号： G01N33/72 ,  G01N31/22 ,  G01N33/16

    CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/146666

    摘要： WHEREIN X is a stabilizing anion; R1 and R2, which may be the same or different, are halogen or lower alkyl or alkoxy and R3 and R4, which may be the same or different, are hydrogen, halogen, nitro, or lower alkyl or alkoxy; THE AROMATIC RING IN FORMULA (I) containing either (a) 1 to 3 halogen atoms or (b) one nitro group, but not both together; and an amount of an acid sufficient for a coupling reaction between bilirubin and said diazonium salt.

    Bilirubin, particularly as contained in body fluids, is determined with test strips comprising an absorbent

    摘要翻译： 特别是包含在体液中的胆红素由包含吸收剂的测试条确定，其中X是稳定的阴离子; R 1和R 2可以相同或不同，为卤素或低级烷基或烷氧基，R 3和R 4可以相同或不同，为氢，卤素，硝基或低级烷基或烷氧基; 式（I）中的芳族环（I）含有（a）1至3个卤素原子或（b）一个硝基，但不包括在一起; 以及一定量的足以用于胆红素与所述重氮盐之间的偶联反应的酸。

    Diagnostic test strip for the detection of components of body fluids
    5.
    发明授权
    Diagnostic test strip for the detection of components of body fluids 失效
    用于检测身体液体组分的诊断测试条

    公开(公告)号：US3853472A

    公开(公告)日：1974-12-10

    申请号：US37624873

    申请日：1973-07-03

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： RITTERSDORF W ,  REY H ,  GUTHLEIN W ,  RIECKMANN P

    IPC分类号： G01N33/50 ,  C12Q1/04 ,  C12Q1/28 ,  G01N31/22 ,  C07D33/00 ,  G01N33/16

    CPC分类号： C12Q1/28 ,  C12Q1/04 ,  Y10S436/904

    摘要： Test strips are provided for detecting even small amounts of blood or other peroxidatively active substances in body fluids; the strips comprising a carrier containing a hydroperoxide, a chromogen, and as an activator, a compound of the formula WHEREIN R1 is a hydrogen atom or a methyl radical and benzene and/or pyridine rings are fused on at least one of the positions indicated with c, (d,e), f and g, provided that two adjacent rings must not simultaneously each contain a cyclic nitrogen atom, and wherein the aromatic compounds (1), apart from the positions indicated by H and R1, can be substituted by lower alkyl radicals which together can also form a hydroaromatic ring.

    摘要翻译： 提供测试条，用于检测体液中的少量血液或其他过氧化物质活性物质; 条带包含含有氢过氧化物，色原体和作为活化剂的载体，式WHEREIN R 1是氢原子或甲基，苯和/或吡啶环稠合在至少一个位置 c，（d，e），f和g，条件是两个相邻的环不能同时各自含有环状氮原子，并且其中芳族化合物（1）除了由H和R 1表示的位置可以被 低级烷基一起也可以形成一个水芳族环。

    Diagnostic composition for the detection of urobilinogen
    6.
    发明授权
    Diagnostic composition for the detection of urobilinogen 失效
    用于检测URIBILINOGEN的诊断组合物

    公开(公告)号：US3850576A

    公开(公告)日：1974-11-26

    申请号：US31406772

    申请日：1972-12-11

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： RIECKMANN P ,  RITTERSDORF W ,  BERGER D ,  REY H

    IPC分类号： G01N33/50 ,  G01N33/15 ,  G01N33/72 ,  G01N33/16

    CPC分类号： G01N33/72 ,  Y10S436/903 ,  Y10T436/146666

    摘要： Urobilinogens, optionally in the presence of bilirubin, are detected with a novel diagnostic agent comprising A. AT LEAST ONE STABLE DIAZONIUM SALT CONTAINING A PHENYL-, PYRROLE, OR PYRAZOLE RING ANNELLATED WITH AN AROMATIC SYSTEM IN A MESOMERIZABLE AND STERICALLY UNHINDERED POSITION OR SUBSTITUTED DIRECTLY OR VIA A VINYLENE RADICAL WITH AN AROMATIC SYSTEM, OR B. A PYRIDINE OR PYRAZOLE DIAZONIUM SALT SUBSTITUTED IN A MESOMERIZABLE POSITION WITH AT LEAST ONE POLYATOMIC ELECTRON DONOR GROUP HAVING AT LEAST ONE MESOMERIZABLE ELECTRON PAIR WITH THE PROVISO THAT THE SUM OF THE Hammett sigma values for all the substituents, and hetero atoms does not exceed the value of +0.6.

    摘要翻译： 任选地在胆红素存在下，用包含A的新型诊断剂检测无脊椎动物细胞。在具有可置换和无规定位置或直接取代的芳香系统中的至少一种稳定的二苯并三唑盐包含苯基，吡咯或吡唑环。 或通过具有芳族体系的乙烯基离子，或B.在具有至少一个可聚合电子对的至少一个可聚合电子对的可可位置中取代的吡啶或吡唑二盐，其具有Hammett sigma值的值 对于所有取代基，杂原子不超过+0.6的值。

    N(6)-disubstituted adenosine compounds
    7.
    发明授权
    N(6)-disubstituted adenosine compounds 失效
    N（6） - 衍生腺苷化合物

    公开(公告)号：US3840521A

    公开(公告)日：1974-10-08

    申请号：US28711572

    申请日：1972-09-07

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： FAULAND E ,  KAMPE W ,  ROESCH E ,  THIEL M ,  STORK H

    IPC分类号： C07H19/16 ,  C07D51/54

    CPC分类号： C07H19/16

    摘要： 1. N(6)-DISUBSTITUTED ADENOSINE COMPOUND OF THE FORMULA

    6-(R1-N(-R2)-),9-(3,4,5-TRI(HO-)-TETRAHYROFUR-2-YL-)-

    9H-PURINE

    WHEREIN R1 IS ALKYL OF FROM 1 TO 6 CARBON ATOMS; AND R2 IS STRAIGHT-CHAINED OR BRANCHED ALKYL OF FROM 4 TO 10 CARBON ATOMS; CYCLOALKYL OR METHYLCYCLOALKYL WHEREIN THE CYCLOALKYL MOIETY CONTAINS FROM 3 TO 10 CARBON ATOMS, CYCLOALKYL-ALKYL WITH FROM 3 TO 10 CARBON ATOMS IN THE CYCLOALKYL GROUP AND FROM 1 TO 4 CARBON ATOMS IN THE ALKYL SIDE-CHAIN OR BICYCLOALKYL OF FROM 5 TO 7 CARBON ATOMS IN EACH RING; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.