METHODS OF FORMING RADIOPAQUE PEPTIDES AND MEDICAL HYDROGELS FORMED THEREFROM

    公开(公告)号:US20250059237A1

    公开(公告)日:2025-02-20

    申请号:US18804679

    申请日:2024-08-14

    Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.

    MEDICAL DEVICES FOR FLUID DELIVERY AND RELATED METHODS OF USE

    公开(公告)号:US20250057407A1

    公开(公告)日:2025-02-20

    申请号:US18938545

    申请日:2024-11-06

    Abstract: A medical device may include an insertion portion longitudinally extending between a proximal end and a distal end. The insertion portion may define a channel extending therethrough. The medical device may further include a handle coupled to the proximal end of the insertion portion. The handle may further include an irrigation port in fluid communication with the channel and coupled to a source of irrigation fluid. Additionally, the handle may include an actuator and a pressurizer. Manipulation of the actuator may be configured to actuate the pressurizer to urge irrigation fluid distally through the channel.

    Fluidization devices and methods of use

    公开(公告)号:US12226793B2

    公开(公告)日:2025-02-18

    申请号:US18496982

    申请日:2023-10-30

    Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.

    Biliary Stents and Methods
    4.
    发明申请

    公开(公告)号:US20250049556A1

    公开(公告)日:2025-02-13

    申请号:US18928829

    申请日:2024-10-28

    Abstract: A tissue lumen stent is provided with a body having an elongated tubular configuration and a foreshortened configuration. In the foreshortened configuration, downstream and upstream ends of the body expand radially into downstream and upstream flange structures, leaving a generally cylindrical saddle region therebetween. In some embodiments, the flange structures are non-symmetrical with respect to one another. Systems and methods of using the stents are also disclosed.

    MEDICAL ASSEMBLIES, DEVICES, SYSTEMS, AND RELATED METHODS FOR MULTIPLE SENSORS

    公开(公告)号:US20250040893A1

    公开(公告)日:2025-02-06

    申请号:US18788657

    申请日:2024-07-30

    Inventor: Michael McGOVERN

    Abstract: A medical system includes a processing unit, a medical device electrically coupled to the processing unit, and an electronic assembly disposed at a distal portion of the insertion portion. The medical device includes an insertion portion configured to be inserted into a body lumen of a subject. The electronic assembly includes at least a first sensor, a second sensor, and a switch. The electronic assembly is electrically coupled to the processing unit. The switch is configured to switch between the first sensor and the second sensor based on an instruction of the processing unit.

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