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    2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes
    5.
    发明申请
    2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes 审中-公开
    2-硫代乙内酰脲衍生物及其用于治疗糖尿病的用途

    公开(公告)号：US20060025589A1

    公开(公告)日：2006-02-02

    申请号：US10529817

    申请日：2003-10-03

    申请人： Jean Binet ,  Benaissa Boubia ,  Evelyne Chaput ,  Alan Edgar ,  Khan Ou ,  Philippe Ratel ,  Soth Samreth ,  Didier Thomas

    发明人： Jean Binet ,  Benaissa Boubia ,  Evelyne Chaput ,  Alan Edgar ,  Khan Ou ,  Philippe Ratel ,  Soth Samreth ,  Didier Thomas

    IPC分类号： C07D413/02 ,  C07D405/02 ,  C07D403/02

    CPC分类号： C07D401/04 ,  C07D233/86 ,  C07D401/12 ,  C07D405/04

    摘要： The invention relates to 2-thiohydantoin compounds selected from compounds of general formula (I): in which, in particular, one of the radicals R1 and R2 comprises two aromatic rings in the structure or is the dibenzofuranyl group, R3 is a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a hydroxyl group, a phenyl group or a benzyl group, R4 is a hydrogen atom, a halogen atom or a C1-C4 alkyl group, and their addition salts with a non-toxic acid, especially the pharmaceutically acceptable salts. It further relates to the process for their preparation, to the pharmaceutical compositions in which they are present, and to their use as pharmacologically active substances, especially in the case of the treatment of diabetes, diseases due to hyperglycemia, hypertriglyceridemia, dyslipidemia or obesity.

    摘要翻译： 本发明涉及选自通式（I）的化合物的2-硫代乙内酰脲化合物：其中特别地，基团R 1和R 2中的一个包含两个芳族 结构中的环或是二苯并呋喃基，R 3是氢原子，卤素原子，C 1 -C 4烷基 C 1 -C 4烷氧基，羟基，苯基或苄基，R 4是氢原子， 卤素原子或C 1 -C 4烷基，以及它们与无毒酸，特别是药学上可接受的盐的加成盐。 其进一步涉及其制备方法，其存在的药物组合物及其作为药理活性物质的用途，特别是在治疗糖尿病，由于高血糖症，高甘油三酯血症，血脂异常或肥胖症引起的疾病的情况下。