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公开(公告)号：US5240000A
公开(公告)日：1993-08-31
申请号：US780115
申请日：1991-10-21
申请人： Bernhard Herrmann , Jurgen Neumann
发明人： Bernhard Herrmann , Jurgen Neumann
CPC分类号： A61B17/2255 , A61B2017/00902 , A61B90/39
摘要： A targeting device for x-ray locating during an extracorporeal treatment of patients with focused shock waves, particularly for a lithotritor, is suggested. The targeting device comprises a carrier on or in which x-ray positive elements, preferably metal wires, are arranged such that they point to the focal point of the shock wave system. In the x-ray image, the position of the elements clearly indicates the position of the focal point.
摘要翻译： 建议在针对冲击波的患者进行体外治疗期间进行x射线定位的靶向装置，特别是用于碎石机的靶向装置。 靶向装置包括在其上或其中x射线正元件（优选金属线）布置的载体，使得它们指向冲击波系统的焦点。 在x射线图像中，元素的位置清楚地指示焦点的位置。
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公开(公告)号：US5152289A
公开(公告)日：1992-10-06
申请号：US513612
申请日：1990-04-24
CPC分类号： A61B17/2255 , A61B8/0833
摘要： A lithotripter includes a therapeutic head provided with a source for focusing shockwaves in a focal point on a first axis; an ultrasonic transducer having an axis for imaging an area in a patient in which shockwaves are to be focussed is connected to the therapeutic head for movement in relation to the head in isocentric relation to that focal point such that two axes intersect in that focal point, independently form a variable angular orientation of the axes to each other.
摘要翻译： 碎石器包括设置有用于将冲击波聚焦在第一轴上的焦点上的治疗头; 超声换能器具有成像用于使患者中的区域成像的轴，其中冲击波将聚焦在该治疗头上，用于相对于与该焦点以等心中心关系的头部移动，使得两个轴在该焦点相交， 彼此独立地形成轴的可变角度取向。
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3.发明授权公开(公告)号：US06642369B1
公开(公告)日：2003-11-04
申请号：US09554726
申请日：2000-07-26
IPC分类号： C12N1511
CPC分类号： C12N9/12 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The present invention relates to nucleic acid molecules encoding expression products involved in the Responder function, which contributes to the phenomenon of transmission ratio distortion. The present invention also relates to regulatory regions of the genes corresponding to the nucleic acid molecules. The present invention further relates to recombinant DNA molecules and vectors comprising the nucleic acid molecules and/or regulatory regions as well as to host cells transformed therewith. Additionally, the present invention relates to transgenic animals, comprising the nucleic acid molecules, recombinant DNA molecules or vectors stably integrated into their genome. The various embodiments of the invention have a significant impact on breeding strategies by allowing for the specific selection of genetic traits and in particular of sex. Further, the present invention finds applications in the development of contraceptive.
摘要翻译： 本发明涉及编码涉及响应者功能的表达产物的核酸分子，其有助于传输比失真的现象。 本发明还涉及对应于核酸分子的基因的调节区。 本发明还涉及重组DNA分子和包含核酸分子和/或调节区的载体以及与其转化的宿主细胞。 另外，本发明涉及转基因动物，其包含核酸分子，重组DNA分子或稳定整合到其基因组中的载体。 本发明的各种实施方案通过允许遗传特性，特别是性别的特定选择，对育种策略具有显着影响。 此外，本发明应用于避孕方面的开发。
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公开(公告)号：US5070861A
公开(公告)日：1991-12-10
申请号：US535719
申请日：1990-06-11
CPC分类号： A61B17/2255 , A61B6/12 , A61B2017/00902 , A61B90/39
摘要： A lithotripter has a source for focussed shockwaves and an X-ray device which is mounted for relative displacement and positioning in relation to that source of shockwaves; an improvement includes a device for aiming and sighting in cooperation with the X-ray equipment that includes a carrier element defining a first pair of X-ray contrasting aligned reference points and two additional X-ray contrasting reference points, on a second line and intersecting the first line at a point of intersection at about 15 to 45 degrees; and that aiming and sighting device is mounted in relation to said source of focussed shockwaves such that the point of intersection coincide with a focal point of the shockwave source.
摘要翻译： 碎石机具有聚焦冲击波源和X射线装置，其安装用于相对于冲击波源的相对位移和定位; 改进包括与X射线设备协同瞄准和瞄准的装置，该装置包括在第二线上限定第一对X射线对比对准参考点和两个附加X射线对比参考点的载体元件，并且相交 交叉点的第一条线在大约15到45度之间; 并且瞄准装置和瞄准装置相对于所述聚焦冲击波源安装，使得交点与冲击波源的焦点重合。
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公开(公告)号：US20090307790A1
公开(公告)日：2009-12-10
申请号：US11997992
申请日：2006-08-12
申请人： Bernhard Herrmann , Hermann Bauer
发明人： Bernhard Herrmann , Hermann Bauer
IPC分类号： A01K67/027 , C12Q1/68 , C12P21/00 , C12N5/06 , C12N15/63 , G01N33/00 , C07H21/00 , C12N15/85
CPC分类号： C07K14/4702 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/4706 , C12N15/8509 , C12N2800/30 , Y10T436/143333
摘要： The present invention relates to a method for producing a transgenic non human male animal, preferably a mammal, fish, bird or insect, wherein the transgene(s) confer(s) a change in the transmission ratio of (a) genetic trait(s) to the offspring of said non human male animal, preferably mammal, fish, bird or insect to a non-Mendelian ratio, said method comprising introducing (a) a first nucleic acid molecule encoding an expression product with a Responder function into a chromosome of a non-human germ cell, (fertilized) egg cell, embryonic cell or a cell derived therefrom, of the same species as the transgenic male to be prepared, said chromosome containing or conferring said genetic trait(s), thereby linking on said chromosome said Responder function to the genetic trait(s); and (b) at least one second nucleic acid molecule encoding an expression product with a Distorter function into (a) chromosome(s) of a non-human germ cell, (fertilized) egg cell, embryonic cell or a cell derived therefrom, of the same species as the transgenic male to be prepared, wherein said expression product with a Distorter function is a factor involved in G protein signaling, wherein said first nucleic acid molecule encoding an expression product with Responder function and said at least one second nucleic acid molecule encoding an expression product with a Distorter function are introduced into the same or different chromosomes.
摘要翻译： 本发明涉及一种生产转基因非人雄性动物，优选哺乳动物，鱼，鸟或昆虫的方法，其中转基因赋予（a）遗传性状（s）的传播比的变化 ），所述方法包括将编码具有应答器功能的表达产物的第一核酸分子引入到所述非人类雄性动物的优选哺乳动物，鱼，鸟或昆虫的非孟德尔比例的染色体中 与受精的卵母细胞，受精的卵细胞，胚胎细胞或源自其的细胞，与待制备的转基因雄性相同的种类，所述染色体含有或赋予所述遗传性状，从而在所述染色体上连接 表示响应者对遗传特性的功能; 和（b）编码具有Distorter功能的表达产物的至少一个第二核酸分子，其转化为（a）非人生殖细胞（受精）卵细胞，胚胎细胞或其衍生的细胞的染色体 与待制备的转基因雄性相同的物种，其中所述具有Distorter功能的表达产物是参与G蛋白信号传导的因子，其中所述编码具有Responder功能的表达产物的第一核酸分子和所述至少一种第二核酸分子 将具有Distorter功能的表达产物编码到相同或不同的染色体中。
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