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公开(公告)号：US20110033524A1
公开(公告)日：2011-02-10
申请号：US12937029
申请日：2009-04-07
IPC分类号： A61K38/48 , A61K9/127 , A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： A61K38/4813 , A61K9/0019 , C12Y304/17023
摘要： The invention provides for innovative improvements in tumour therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity.
摘要翻译： 本发明提供了在肿瘤治疗方面的创新改进，特别是使用内源性物质进行治疗并且没有或仅有轻微的副作用的疗法。 因此，本发明涉及治疗或预防除肺癌以外的肿瘤疾病的方法，包括给予具有血管紧张素转化酶-2（ACE2）活性的多肽。
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公开(公告)号：US20150139942A1
公开(公告)日：2015-05-21
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K31/485 , A61K39/395 , A61K45/06
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.
摘要翻译： 本发明涉及一种治疗GD2阳性癌症的方法，其通过以每天24小时连续静脉内输注给患者施用包含抗GD2抗体的制剂。
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公开(公告)号：US09777068B2
公开(公告)日：2017-10-03
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K39/395 , A61K31/485 , A61K45/06 , A61K39/00
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.
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公开(公告)号：US08946162B2
公开(公告)日：2015-02-03
申请号：US12937029
申请日：2009-04-07
CPC分类号： A61K38/4813 , A61K9/0019 , C12Y304/17023
摘要： The invention provides for innovative improvements in tumor therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity.
摘要翻译： 本发明提供了在肿瘤治疗方面的创新改进，特别是使用内源性物质进行治疗并且没有或仅有轻微的副作用的疗法。 因此，本发明涉及治疗或预防除肺癌以外的肿瘤疾病的方法，包括给予具有血管紧张素转化酶-2（ACE2）活性的多肽。
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公开(公告)号：US08586319B2
公开(公告)日：2013-11-19
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译： 本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。 二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。
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公开(公告)号：US20100310546A1
公开(公告)日：2010-12-09
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译： 本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。 二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。
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