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公开(公告)号:US08129434B2
公开(公告)日:2012-03-06
申请号:US12333190
申请日:2008-12-11
申请人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号: A61K31/015 , C07C15/12
CPC分类号: C07H7/04
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US08106021B2
公开(公告)日:2012-01-31
申请号:US12917367
申请日:2010-11-01
申请人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号: C07H7/04 , C07D309/10 , C07D407/12
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US07838499B2
公开(公告)日:2010-11-23
申请号:US12197095
申请日:2008-08-22
申请人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号: C07H7/04 , C07D309/10 , C07D407/12
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US07803778B2
公开(公告)日:2010-09-28
申请号:US11752226
申请日:2007-05-22
申请人: Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
发明人: Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
CPC分类号: C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US20140011754A9
公开(公告)日:2014-01-09
申请号:US13158724
申请日:2011-06-13
申请人: Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人: Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号: A61K31/7034 , C07H1/06 , A61P3/10 , A61P5/48 , A61P3/00 , A61P35/00 , A61P7/00 , A61P3/04 , A61P7/10 , A61P3/06 , A61P9/04 , A61P9/10 , C07H7/04 , A61P9/12
CPC分类号: C07H1/06 , C07D309/10 , C07H7/04
摘要: Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物,制备结晶化合物的方法,以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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公开(公告)号:US07838498B2
公开(公告)日:2010-11-23
申请号:US12060767
申请日:2008-04-01
申请人: Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
发明人: Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
CPC分类号: C07H7/04 , A61K38/00 , C07D309/10
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US20100063141A1
公开(公告)日:2010-03-11
申请号:US12503384
申请日:2009-07-15
申请人: Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人: Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号: A61K31/35 , C07D315/00 , C07C15/16
CPC分类号: A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US20090118201A1
公开(公告)日:2009-05-07
申请号:US12197095
申请日:2008-08-22
申请人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人: Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号: A61K31/7028 , C07H7/04 , C07H7/06 , A61P3/10
CPC分类号: C07H7/04 , C07D309/10 , C07D407/12
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US08987323B2
公开(公告)日:2015-03-24
申请号:US13158724
申请日:2011-06-13
申请人: Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人: Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号: A01N43/16 , A61K31/35 , A01N43/02 , A61K31/335 , A01N43/00 , A61K31/33 , C07D315/00 , C07D309/10
CPC分类号: C07H1/06 , C07D309/10 , C07H7/04
摘要: Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物,制备结晶化合物的方法,以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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公开(公告)号:US20120238510A1
公开(公告)日:2012-09-20
申请号:US13158724
申请日:2011-06-13
申请人: Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人: Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号: A61K31/7034 , C07H1/06 , A61P3/10 , A61P5/48 , A61P3/00 , A61P35/00 , A61P7/00 , A61P3/04 , A61P7/10 , A61P3/06 , A61P9/04 , A61P9/10 , C07H7/04 , A61P9/12
CPC分类号: C07H1/06 , C07D309/10 , C07H7/04
摘要: Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物,制备结晶化合物的方法,以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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