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46 条记录 (耗时 0.016 秒)

    LACTIC ACID BACTERIA, METHODS AND USES THEREOF
    1.
    发明申请
    LACTIC ACID BACTERIA, METHODS AND USES THEREOF 有权

    公开(公告)号：US20220168365A1

    公开(公告)日：2022-06-02

    申请号：US17670968

    申请日：2022-02-14

    申请人： BIOGAIA AB

    发明人： Stefan Roos

    IPC分类号： A61K35/747 ,  C12N1/20

    摘要： The present invention relates to novel strains of lactic acid bacteria, more specifically, novel strains of Lactobacillus reuteri, capable of utilizing ethanolamine. This characteristic makes it possible for the bacteria to compete for the same substrate as pathogenic ethanolamine-utilizing pathogens, thereby presenting an effective means to combat infections resulting from such pathogenic bacteria. There is also provided a method of selecting further ethanolamine-utilizing lactic acid bacteria, as well as other methods and uses involving said novel strains and other ethanolamine-utilizing lactic acid bacteria.

    METHOD FOR SELECTION OF AGENTS INFLUENCING INTESTINAL MOTILITY DISORDERS AND PAIN
    2.
    发明申请
    METHOD FOR SELECTION OF AGENTS INFLUENCING INTESTINAL MOTILITY DISORDERS AND PAIN 审中-公开

    公开(公告)号：US20190112676A1

    公开(公告)日：2019-04-18

    申请号：US16217507

    申请日：2018-12-12

    申请人： BioGaia AB

    发明人： Eamonn Connolly ,  Wolfgang Kunze ,  John Bienenstock

    IPC分类号： C12R1/225 ,  A61K49/00 ,  C12N1/20 ,  A61K35/74 ,  A61K35/747 ,  G06T7/00 ,  A23L33/135

    摘要： A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.

    SEROTONIN PRODUCING BACTERIA
    6.
    发明申请
    SEROTONIN PRODUCING BACTERIA 有权

    公开(公告)号：US20220354909A1

    公开(公告)日：2022-11-10

    申请号：US17623543

    申请日：2020-11-06

    申请人： BIOGAIA AB

    发明人： Estelle Grasset ,  Muhammed Khan ,  Bo Möllstam ,  Stefan Roos

    IPC分类号： A61K35/747 ,  C12N1/20 ,  C12Q1/02 ,  A61P25/00

    摘要： The invention relates to selection of bacterial strain for use in treating serotonin deficiency and/or a disease related to serotonin deficiency by culturing bacteria of a lactic acid producing bacterial strain, under aerobic conditions, in a culture medium comprising tryptophan. Any serotonin produced by the bacteria of the lactic acid producing bacterial strain in the culture medium is detected and the lactic acid producing bacterial strain is selected as effective in treating serotonin deficiency and/or a disease related to serotonin deficiency in a subject if serotonin is detected in the culture medium.

    Lactic acid bacteria, methods and uses thereof
    7.
    发明授权
    Lactic acid bacteria, methods and uses thereof 有权

    公开(公告)号：US11285181B2

    公开(公告)日：2022-03-29

    申请号：US16496509

    申请日：2018-03-27

    申请人： BIOGAIA AB

    发明人： Stefan Roos

    IPC分类号： A61K35/747 ,  C12N1/20 ,  A61K35/00 ,  C12R1/225

    摘要： The present invention relates to novel strains of lactic acid bacteria, more specifically, novel strains of Lactobacillus reuteri, capable of utilizing ethanolamine. This characteristic makes it possible for the bacteria to compete for the same substrate as pathogenic ethanolamine-utilizing pathogens, thereby presenting an effective means to combat infections resulting from such pathogenic bacteria. There is also provided a method of selecting further ethanolamine-utilizing lactic acid bacteria, as well as other methods and uses involving said novel strains and other ethanolamine-utilizing lactic acid bacteria.