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公开(公告)号：US07595187B2
公开(公告)日：2009-09-29
申请号：US11274683
申请日：2005-11-14
申请人： Bradley A. Haltli
发明人： Bradley A. Haltli
摘要： The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that contains at least one gene or a part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of elaiophylin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.
摘要翻译： 本发明特别涉及可从链霉菌基因组内的基因簇获得的DNA片段，该基因簇负责叶黄素生物合成，并且含有至少一个基因或编码直接涉及的多肽的基因的一部分，或 间接地在叶绿素的生物合成中以及制备所述DNA片段的方法。 本发明还涉及含有根据本发明的一个DNA片段和由其衍生的质粒和载体的重组DNA分子。 还包括用所述质粒或载体DNA转化的宿主生物。
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公开(公告)号：US20080274959A1
公开(公告)日：2008-11-06
申请号：US11794068
申请日：2005-12-16
申请人： Bradley A. Haltli , Haiyin He , Ying Huang , Sridhar Krishna Rabindran , Jiang Wu , Min He
发明人： Bradley A. Haltli , Haiyin He , Ying Huang , Sridhar Krishna Rabindran , Jiang Wu , Min He
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/15 , C12P21/00 , C07H17/08 , C07K14/37 , G01N33/566 , C12N1/14 , G01N33/53 , A61P35/00
CPC分类号： C12N15/52
摘要： The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.
摘要翻译： 本发明提供由放线菌属（Actinomadura sp。）生产的色素蛋白 21G792，以及发色蛋白的脱辅基蛋白组分的氨基酸和核酸序列以及发色团的生物合成途径的组分。 本发明可用于开发药物和治疗诸如癌症或细菌感染的疾病。
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