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公开(公告)号：US08948836B2
公开(公告)日：2015-02-03
申请号：US10746129
申请日：2003-12-26
IPC分类号： A61B5/145 , A61B5/1473 , A61B5/1468 , A61B5/1486 , A61B5/02 , A61B5/024 , A61B5/021 , A61B5/0215 , A61B5/01 , A61B5/1459 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/14865 , A61B5/01 , A61B5/0215 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14551 , A61B5/1459 , A61B5/412 , A61B5/4839 , A61B5/6852 , A61B2562/063
摘要： An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.
摘要翻译： 用于感测多个参数的装置包括可植入的壳体和设置在可植入壳体内的多个可植入传感器。 多个可植入传感器感测患者中的参数，例如生物或生理参数，并且各自对患者中的分析物进行响应。 多个可植入传感器可以包括但不限于电化学，电位，电流和光学传感器。
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公开(公告)号：US07468033B2
公开(公告)日：2008-12-23
申请号：US10935954
申请日：2004-09-08
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US4955861A
公开(公告)日：1990-09-11
申请号：US184352
申请日：1988-04-21
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2005/1581 , A61M2039/0211 , A61M2039/0217 , A61M2209/045
摘要： A dual access infusion or monitoring system comprises implantable apparatus and an injection needle. This system enables one to introduce into or withdraw from the apparatus, after it is implanted, a plurality of fluids simultaneously with only a single penetration of the patient's skin. The implantable apparatus includes a sealed housing with an inlet passage extending into the housing which passage has an outer end adjacent to the housing surface and an inner end located inside the housing. A needle stop is positioned at the inner end of that passage and self-sealing septa are mounted at different locations along the passage at selected spacings from the needle stop so as to divide the passage into aligned compartments or segments each of which has its own fluid outlet. The injection needle includes a plurality of lumens, the number of same corresponding to the number of different compartments in the apparatus housing. The proximal ends of the lumens are connected to different passages in a hub and the lumens have outlet openings spaced at different locations along the needle from the needle tip in correspondence with the spacings of the housing passage compartments so that when the needle is inserted into the housing passage through the septa until the needle bottoms on the needle stop, each outlet opening in the needle will be positioned in a different compartment in the housing passage, with all of the needle openings being isolated in a fluid-tight manner from one another and from the atmosphere by at least one septum.
摘要翻译： 双入口输注或监测系统包括可植入装置和注射针。 该系统使得能够在植入之后将多个流体同时引入到患者皮肤的单次穿透中或从该装置中排出。 可植入装置包括密封壳体，其具有延伸到壳体中的入口通道，该通道具有与壳体表面相邻的外端和位于壳体内部的内端。 针止动器位于该通道的内端，并且自密封隔片沿着通道以不同位置安装在与针止动件的选定间隔处，以便将通道分成对准的隔室或段，每个隔间或段具有其自身的流体 出口。 注射针包括多个腔，其数量相当于装置壳体中不同隔室的数量。 内腔的近端连接到轮毂中的不同通道，并且腔与出口开口相对应地具有与针尖相反的沿着针的不同位置处的出口开口，使得当针插入 壳体通过隔片通过直到针停止处的针底部，针中的每个出口开口将被定位在壳体通道中的不同隔室中，所有的针开口彼此以流体密封的方式隔离，并且 从大气中至少有一个隔膜。
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公开(公告)号：US07833157B2
公开(公告)日：2010-11-16
申请号：US12121647
申请日：2008-05-15
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译： 一种多管导管，其具有延伸到导管内腔内的管道。 流明可用于血液，药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。 在其他版本中，中心线导管可以具有另外的流明用于其他目的。 此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。
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公开(公告)号：US20100010330A1
公开(公告)日：2010-01-14
申请号：US12564830
申请日：2009-09-22
申请人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
发明人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
IPC分类号： A61B5/145
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device.
摘要翻译： 本文描述了用于流体输注系统的监视器装置及其操作，显示和数据处理特性。 监测装置的一个实施例用于具有胰岛素输注泵和连续葡萄糖传感器发射器的胰岛素输注系统中。 监视器装置被配置为无线床边监视器，其从诸如输液泵或传感器发射器的流体输注系统中的装置无线地接收状态数据。 监视器设备支持许多用户界面功能，警报/警报功能和图形显示功能，其中这些功能可提高监视器设备的整体操作和用户友好性。 例如，监视器设备可以生成状态图标，其图形地指示输注系统中的设备的可耗费操作量（例如，电池充电，流体存储器容积，或校准或更换周期）的剩余时间。 监视器装置还可以基于由监视器装置接收的经验测量数据来估计被监视患者的生理特征的未来测量。
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公开(公告)号：US20090267774A1
公开(公告)日：2009-10-29
申请号：US12423964
申请日：2009-04-15
IPC分类号： G08B23/00
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1112 , A61B5/1468 , A61B5/1473 , A61B2560/045 , B60K28/063 , B60K28/066 , G06F19/00
摘要： An automobile monitoring system to monitor user body characteristics, includes at least one sensor to monitor at least one user body characteristic. The at least one sensor is operatively coupled to a body of a user to monitor the at least one user body characteristic while the user is operating an automobile. The at least one user body characteristic is at least a glucose level of the user's body. At least one transmitter is operatively coupled to the at least one sensor to communicate sensor data obtained from the at least one sensor while the user is operating the automobile. Automobile electronics are operatively coupled to the at least one transmitter to receive sensor data from the at least one sensor while the user is operating the automobile. The automobile electronics provide the sensor data to the user while the user is operating the automobile. A mobile telephone is operatively coupled to the automobile electronics, wherein the automobile electronics initiate a communication via the mobile telephone based on the sensor data received from the at least one sensor.
摘要翻译： 监视用户身体特征的汽车监控系统包括至少一个用于监视至少一个用户身体特征的传感器。 所述至少一个传感器可操作地联接到使用者的身体，以在用户操作汽车时监视所述至少一个用户身体的特征。 所述至少一个使用者身体特征至少是使用者身体的葡萄糖水平。 至少一个发射器可操作地耦合到所述至少一个传感器，以在用户操作汽车的同时传送从所述至少一个传感器获得的传感器数据。 汽车电子设备可操作地耦合到至少一个发射器，以在用户操作汽车时从至少一个传感器接收传感器数据。 汽车电子设备在用户操作汽车时向用户提供传感器数据。 移动电话可操作地耦合到汽车电子设备，其中汽车电子设备基于从至少一个传感器接收的传感器数据，经由移动电话发起通信。
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公开(公告)号：US20090062767A1
公开(公告)日：2009-03-05
申请号：US11897106
申请日：2007-08-29
申请人： Nannette M. Van Antwerp , Rajiv Shah , Bradley J. Enegren , Richard Lemos, JR. , Ly Phou , Garry M. Steil , Gayane R. Voskanyan
发明人： Nannette M. Van Antwerp , Rajiv Shah , Bradley J. Enegren , Richard Lemos, JR. , Ly Phou , Garry M. Steil , Gayane R. Voskanyan
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/4839 , A61B5/6846 , A61B5/6848 , A61B5/6849 , A61M5/14248 , A61M5/158 , A61M5/172 , A61M2005/14252 , A61M2005/1585 , A61M2005/1586 , A61M2005/1587 , A61M2005/1726 , A61M2230/201
摘要： Embodiments of the invention provide a dual insertion set for supplying a fluid to the body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the piercing member for supplying a fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to the skin of a patient. Typically the infusion portion and sensor portion piercing members are arranged such that when they are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula.
摘要翻译： 本发明的实施例提供了一种用于向患者的身体供应流体并用于监测患者的身体特征的双重插入组。 本发明的典型实施例包括底座，联接到第一刺穿构件的输注部分和联接到第二穿刺构件的传感器部分。 输注部分包括联接到穿刺构件的套管，用于将流体供应到放置位置。 所述传感器部分包括传感器，所述传感器耦合到所述底座并且具有至少一个传感器电极并从所述底座延伸并且以允许所述传感器插入所述放置位置的方式联接到所述穿孔构件。 基座设置成将双重插入件固定到患者的皮肤上。 通常，输注部分和传感器部分刺穿构件被布置成使得当它们可操作地联接到基部时，它们被设置成空间方向，其设计成阻止可能由存在于通过插管注入的流体中的化合物引起的传感器干扰。
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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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9.发明授权Infusion medium delivery device and method with drive device for driving plunger in reservoir 有权输液介质输送装置及其驱动装置，用于驱动储液器中的柱塞公开(公告)号：US08277415B2
公开(公告)日：2012-10-02
申请号：US11604172
申请日：2006-11-22
申请人： R. Paul Mounce , Melissa D. Norton , Robert M. Guezuraga , Bradley J. Enegren , Paul F. Bente, IV , Ian B. Hanson , Julian D. Kavazov , Christopher G. Griffin , Sheldon B. Moberg , Mark D. Holt , Susie E. Maule , Paul H. Kovelman
发明人： R. Paul Mounce , Melissa D. Norton , Robert M. Guezuraga , Bradley J. Enegren , Paul F. Bente, IV , Ian B. Hanson , Julian D. Kavazov , Christopher G. Griffin , Sheldon B. Moberg , Mark D. Holt , Susie E. Maule , Paul H. Kovelman
CPC分类号： A61M5/1413 , A61J1/1406 , A61J1/2096 , A61M5/14248 , A61M5/1456 , A61M5/385 , A61M2005/14252 , A61M2005/14268 , A61M2005/14573 , A61M2205/0266 , A61M2207/00 , A61M2209/045
摘要： A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.
摘要翻译： 输送装置包括耐用的壳体部分和可选择性地接合和分离的可分离的一次性部分。 一次性外壳部分固定在患者使用者身上，并且可以在使用一段规定的时间之后进行处置。 通常与患者使用者或输注介质接触的部件由一次性外壳部分支撑，而耐用的外壳部分支撑诸如电子设备和驱动装置的其它部件。 当一次性和耐用的壳体部分接合时，储存器由一次性外壳部分支撑并且具有可操作地联接到驱动装置的可移动柱塞。
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公开(公告)号：US20110046457A1
公开(公告)日：2011-02-24
申请号：US12917162
申请日：2010-11-01
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译： 一种多管导管，其具有延伸到导管内腔内的管道。 流明可用于血液，药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。 在其他版本中，中心线导管可以具有另外的流明用于其他目的。 此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。
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