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公开(公告)号:US20050222197A1
公开(公告)日:2005-10-06
申请号:US10524577
申请日:2003-09-16
申请人: Douglas Beight , Rosanne Bonjouklian , Junkai Liao , William McMillen , Brandon Parkhurst , Jason Sawyer , Jonathan Yingling , Jeremy York
发明人: Douglas Beight , Rosanne Bonjouklian , Junkai Liao , William McMillen , Brandon Parkhurst , Jason Sawyer , Jonathan Yingling , Jeremy York
IPC分类号: A61K31/4745 , A61K31/502 , A61K31/517 , A61K31/5377 , A61P17/00 , A61P35/00 , C07D471/02 , C07D471/04 , C07D519/00
CPC分类号: C07D471/04
摘要: Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
摘要翻译: 公开了新的吡唑并吡啶衍生物化合物及其作为药剂的用途,特别是其用作TGF-β信号转导抑制剂的用途,其用于治疗受TGFβ影响的癌症和其它疾病状态。
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公开(公告)号:US08420830B2
公开(公告)日:2013-04-16
申请号:US12519376
申请日:2007-12-19
申请人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Peter W. Glunz , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata , Luciano Mueller
发明人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Peter W. Glunz , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata , Luciano Mueller
IPC分类号: A61K31/405
CPC分类号: C07D271/12 , C07D255/04
摘要: The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
摘要翻译: 本发明一般涉及式(I)的新型大环或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,B,C,D,L,M,W,Z1,Z2, Z 3,Z 4,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8,R 9和R 10如本文所定义。 这些化合物是可用作药物的因子VIIa的选择性抑制剂。
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3.
公开(公告)号:US08039506B2
公开(公告)日:2011-10-18
申请号:US12519365
申请日:2007-12-17
申请人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata
发明人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata
IPC分类号: A61K31/4035
CPC分类号: C07D401/12
摘要: The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
摘要翻译: 本发明提供式(I)的新型双环内酰胺衍生物及其类似物:或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,B,C,W,Y, Z2,Z3,Z4,R8和R9如本文所定义。 这些化合物是可用作药物的因子VIIa的选择性抑制剂。
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公开(公告)号:US20100113488A1
公开(公告)日:2010-05-06
申请号:US12519376
申请日:2007-12-19
申请人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Peter W. Glunz , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata , Luciano Mueller
发明人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Peter W. Glunz , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata , Luciano Mueller
IPC分类号: A61K31/517 , C07D209/44 , C07D217/24 , C07D245/04 , C07D239/88 , A61K31/4035 , A61K31/4725 , A61P7/00 , A61P9/00
CPC分类号: C07D271/12 , C07D255/04
摘要: The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
摘要翻译: 本发明一般涉及式(I)的新型大环或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,B,C,D,L,M,W,Z1,Z2, Z 3,Z 4,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8,R 9和R 10如本文所定义。 这些化合物是可用作药物的因子VIIa的选择性抑制剂。
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5.
公开(公告)号:US20100041664A1
公开(公告)日:2010-02-18
申请号:US12519365
申请日:2007-12-17
申请人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata
发明人: Nicholas Ronald Wurtz , Eldon Scott Priestley , Daniel L. Cheney , Xiaojun Zhang , Brandon Parkhurst , Vladimir Ladziata
IPC分类号: A61K31/502 , C07D401/12 , A61K31/4709 , C07D403/12 , A61K31/517
CPC分类号: C07D401/12
摘要: The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
摘要翻译: 本发明提供式(I)的新型双环内酰胺衍生物及其类似物:或其立体异构体,互变异构体,药学上可接受的盐,溶剂合物或前药,其中变量A,B,C,W,Y, Z2,Z3,Z4,R8和R9如本文所定义。 这些化合物是可用作药物的因子VIIa的选择性抑制剂。
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