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公开(公告)号:US20080132511A1
公开(公告)日:2008-06-05
申请号:US11943520
申请日:2007-11-20
申请人: Brett ALLISON , Victor K. Phuong , Marna C.W. Pippel , Michael H. Rabinowitz , Hariharan Venkatesan
发明人: Brett ALLISON , Victor K. Phuong , Marna C.W. Pippel , Michael H. Rabinowitz , Hariharan Venkatesan
IPC分类号: A61K31/498 , C07D285/06 , C07D241/38 , A61P1/16 , A61K31/433
CPC分类号: C07D263/56 , C07C311/21 , C07D241/42 , C07D277/62 , C07D285/14 , C07D317/62 , C07D409/12 , C07D417/12
摘要: Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.
摘要翻译: 某些磺酰胺化合物是可用于治疗CCK1 / CCK2介导的疾病的双CCK1 / CCK2抑制剂。
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公开(公告)号:US20080076918A1
公开(公告)日:2008-03-27
申请号:US11950326
申请日:2007-12-04
申请人: Brett Allison , Michael Hack , Victor Phuong , Michael Rabinowitz , Mark Rosen
发明人: Brett Allison , Michael Hack , Victor Phuong , Michael Rabinowitz , Mark Rosen
IPC分类号: C07D241/36 , C07D267/02 , C07D413/00
CPC分类号: C04B35/632 , C07D241/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要: Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
摘要翻译: 苯基磺酰氨基 - 喹喔啉化合物中的某些化合物是可用于治疗CCK2介导的疾病的CCK2调节剂。
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公开(公告)号:US07264620B2
公开(公告)日:2007-09-04
申请号:US10859962
申请日:2004-06-04
申请人: Brett Allison Taylor
发明人: Brett Allison Taylor
IPC分类号: A61B17/58
CPC分类号: A61B17/7035 , A61B17/7044 , A61B17/7071
摘要: A vertebral implant comprising a first base configured for securing to a first cut portion of a vertebra, and second base configured for securing to a second cut portion of the vertebra. A connecting member is configured to associate the first and second bases at a preselected spacing from each other, and the implant is preferable adjustable to select the spacing.
摘要翻译: 一种脊椎植入物,包括构造成用于固定到椎骨的第一切割部分的第一基底,以及被配置用于固定到椎骨的第二切割部分的第二基底。 连接构件被配置成将第一和第二基底以预选的间隔相互关联,并且植入物优选是可调节的以选择间隔。
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公开(公告)号:US20060223810A1
公开(公告)日:2006-10-05
申请号:US11393558
申请日:2006-03-30
申请人: Brett Allison , Laurent Gomez , Cheryl Grice , Michael Hack , Brian Morrow , S. Motley , Alejandro Santillan , Karen Shaw , Kimberly Schwarz , Liu Tang , Hariharan Venkatesan , John Wiener
发明人: Brett Allison , Laurent Gomez , Cheryl Grice , Michael Hack , Brian Morrow , S. Motley , Alejandro Santillan , Karen Shaw , Kimberly Schwarz , Liu Tang , Hariharan Venkatesan , John Wiener
IPC分类号: A61K31/498 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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公开(公告)号:US08172875B2
公开(公告)日:2012-05-08
申请号:US11766864
申请日:2007-06-22
申请人: Brett Allison Taylor
发明人: Brett Allison Taylor
IPC分类号: A61B17/70
CPC分类号: A61B17/7035 , A61B17/7044 , A61B17/7071
摘要: A vertebral implant comprising a first base configured for securing to a first cut portion of a vertebra, and second base configured for securing to a second cut portion of the vertebra. A connecting member is configured to associate the first and second bases at a preselected spacing from each other, and the implant is preferable adjustable to select the spacing.
摘要翻译: 一种脊椎植入物,包括构造成用于固定到椎骨的第一切割部分的第一基底,以及被配置用于固定到椎骨的第二切割部分的第二基底。 连接构件被配置成将第一和第二基底以预选的间隔相互关联,并且植入物优选是可调节的以选择间隔。
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公开(公告)号:US20080045509A1
公开(公告)日:2008-02-21
申请号:US11766172
申请日:2007-06-21
申请人: Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M. B. Miller , Emily M. Stocking
发明人: Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M. B. Miller , Emily M. Stocking
IPC分类号: A61K31/496 , A61K31/166 , A61K31/4015 , A61K31/5377 , A61P25/00 , A61P25/16 , A61P25/24 , A61P27/00 , A61P31/00 , C07D413/04 , C07D401/14 , C07D401/12 , C07D295/14 , C07D295/00 , C07D243/08 , C07D207/16 , C07C233/78 , A61P3/04 , A61P25/28 , A61P25/18 , A61P25/06 , A61K31/551 , A61K31/4545 , A61K31/495
CPC分类号: C07C237/34 , C07D209/08 , C07D209/40 , C07D213/65 , C07D213/70 , C07D213/74 , C07D241/08 , C07D243/24 , C07D295/13 , C07D295/135 , C07D295/192 , C07D401/10 , C07D401/12 , C07D413/04
摘要: Certain substituted benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译: 某些取代的苄胺化合物是可用于治疗组胺H 3受体和/或5-羟色胺介导的疾病的组胺H 3 N 3受体和/或5-羟色胺转运蛋白调节剂。
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公开(公告)号:US20080045508A1
公开(公告)日:2008-02-21
申请号:US11766153
申请日:2007-06-21
申请人: Brett Allison , Nicholas I. Carruthers , Michael P. Curtis , John M. Keith , Michael A. Letavic , Emily M. Stocking
发明人: Brett Allison , Nicholas I. Carruthers , Michael P. Curtis , John M. Keith , Michael A. Letavic , Emily M. Stocking
IPC分类号: A61K31/551 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/00 , A61P3/04 , A61P31/00 , C07D243/08 , C07D401/12
CPC分类号: C07D243/08 , C07D401/12 , C07D413/12
摘要: Certain substituted aminomethyl benzamide compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译: 某些取代的氨基甲基苯甲酰胺化合物是可用于治疗组胺H 3受体和/或5-羟色胺介导的疾病的组胺H 3 N 3受体和/或5-羟色胺转运体调节剂。
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公开(公告)号:US20070225275A1
公开(公告)日:2007-09-27
申请号:US11726756
申请日:2007-03-21
申请人: Brett Allison , Bryan Branstetter , James Breitenbucher , Michael Hack , Natalie Hawryluk , Alec Lebsack , Kelly McClure , Jeffrey Merit
发明人: Brett Allison , Bryan Branstetter , James Breitenbucher , Michael Hack , Natalie Hawryluk , Alec Lebsack , Kelly McClure , Jeffrey Merit
IPC分类号: A61K31/55 , C07D487/02
CPC分类号: C07D487/04
摘要: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be-administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
摘要翻译: 描述了某些四氢嘧啶并氮杂化合物,其可用作TRPV1调节剂。 这样的化合物可以用于治疗由TRPV1介导的疾病状态,病症和状况的药物组合物和方法。 因此,可以给予化合物以治疗例如疼痛,瘙痒,咳嗽,哮喘或炎症性肠病。
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公开(公告)号:US20070094449A1
公开(公告)日:2007-04-26
申请号:US11260637
申请日:2005-10-26
申请人: Brett Allison , Elise Bobitt
发明人: Brett Allison , Elise Bobitt
IPC分类号: G06F12/00
CPC分类号: G06F11/3485 , G06F3/0613 , G06F3/0631 , G06F3/0647 , G06F3/067 , G06F11/3419 , G06F11/3433 , G06F12/0866 , G06F2201/81 , G06F2201/885
摘要: System, method and program for managing a storage server comprising first and second clusters of storage controllers. The first cluster comprises one or more storage controllers each controlling one or more storage arrays. The first cluster also comprises a first cache memory and a first nonvolatile storage (“NVS”) shared by the one or more storage controllers of the first cluster. The second cluster comprises one or more storage controllers each controlling one or more storage arrays. The second cluster also comprises a second cache memory and a second nonvolatile storage shared by the one or more storage controllers of the second cluster. There is monitoring of an amount of time that data controlled by each of the clusters is held in the cache memory of the cluster before being outpaged to the storage arrays. There is monitoring of an amount of requests to access storage arrays of a cluster that were delayed due to insufficient NVS. A level of impairment of access to each of the storage arrays is determined based on the amount of time that data controlled by each of the clusters was held in the cache memory of the cluster before being outpaged to the storage arrays, and the amount of requests to access the storage arrays of a cluster that were delayed due to insufficient NVS. When access to a storage array is excessively impaired, data is moved from the access-impaired storage array to another storage array with a lower level of access impairment.
摘要翻译: 用于管理包括第一和第二存储控制器簇的存储服务器的系统,方法和程序。 第一集群包括一个或多个存储控制器,每个存储控制器控制一个或多个存储阵列。 第一集群还包括由第一集群的一个或多个存储控制器共享的第一高速缓存存储器和第一非易失性存储器(“NVS”)。 第二集群包括一个或多个存储控制器,每个存储控制器控制一个或多个存储阵列。 第二集群还包括由第二集群的一个或多个存储控制器共享的第二高速缓存存储器和第二非易失性存储器。 在被分组到存储阵列之前,监视由每个集群控制的数据被保持在集群的高速缓冲存储器中的时间量。 正在监视访问由于NVS不足而延迟的集群存储阵列的请求量。 基于在被分组到存储阵列之前,由每个集群控制的数据被保持在集群的高速缓冲存储器中的时间量以及请求量来确定对每个存储阵列的访问的损害级别 以访问由于NVS不足而延迟的集群的存储阵列。 当对存储阵列的访问过度受损时,数据从访问受损存储阵列移动到具有较低访问损害水平的另一个存储阵列。
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公开(公告)号:US20070066821A1
公开(公告)日:2007-03-22
申请号:US11531849
申请日:2006-09-14
IPC分类号: A61K31/541 , C07D417/02 , C07D413/02
CPC分类号: C07D295/192 , C07D211/38 , C07D265/30
摘要: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
摘要翻译: 某些环丙基胺是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N调节剂。
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